DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and copa-1

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_491069.1	Gene:	copa-1 / 171860	WormBaseID:	WBGene00022119	Length:	1232	Species:	Caenorhabditis elegans

Alignment Length:	1061	Identity:	203/1061 - (19%)
Similarity:	346/1061 - (32%)	Gaps:	317/1061 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 MLCQMDQHLACVNCVRWSQNGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLR 126
            :|.:.|:|...|..:.:..:.....||.||..|.:|                 |::..:|.:||.
Worm    45 LLEKFDEHDGPVRGICFHHDQPIFVSGGDDYKIKVW-----------------NYKQKRCIFTLL 92

  Fly   127 GHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQS 191
            ||...:....:.....::.|.|.|.||.||:.|: .:|:|.|.||...|....:.|....:||.|
Worm    93 GHLDYIRTTFFHHKYPWIISASDDQTVRIWNWQS-RNSIAILTGHNHYVMCAQFHPTEDLVASAS 156

  Fly   192 DDRSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGW 256
            .|:::::|:...                    ||....|.|    .|.:...||..|::..:...
Worm   157 LDQTVRVWDISG--------------------LRKKQMPGG----GAPSRPTGGQQAELFGQPDA 197

  Fly   257 KCDKDFVGHRKAVTCVRFHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLSVWMTALQRPMVVIH 321
            .......||.:.|..|.||:            :.|:    |..||.||.:.:|.....:..
Worm   198 VVKHVLEGHDRGVNWVAFHH------------TNPI----LVSGSDDRQVKIWRYNETKAW---- 242

  Fly   322 EL------FNASILDLTWGPQECLLMACSVDGSIACLKFTEEELGKAIS------EEEQNAIIR- 373
            ||      :| ::..:.:.|...|:::.|.|.||...     ::.|..|      |.|:..::.
Worm   243 ELDSCRGHYN-NVSSVIFHPNADLILSNSEDKSIRVW-----DMQKRTSLHVFRHENERFWVLAA 301

  Fly   374 ----KMYGKNYVNGLGKSAPVLEHPQRLLLPQGDKPTKFPLSNN--NEANQRPISKQTETRTKD- 431
                .|:...:.||:     |:...||      ::|. :.:|:|  .....:.|.|...|..||
Worm   302 HPSLNMFAAGHDNGM-----VVFKIQR------ERPA-YCVSDNLVFYVKGQQIRKLDLTTNKDV 354

  Fly   432 ---GKRRITPMFIPLHEDGPTSLSMNIVSSSGSSTTALTS---------------CSAAIGTLPA 478
               ..|...|...|.:     |||.|    ....|..|||               .|.:.||..|
Worm   355 ALCKLRYPQPFMQPYY-----SLSFN----PAEGTFLLTSRTHNKDLCAFELYKVASNSDGTTEA 410

  Fly   479 AAPTESAATPLMPLEPLVSKIDLGRLDSRLKTQPASQRRQSLPFDPGQSNELLRTPRLEEHQSST 543
            |....:....|.     |::.....||   |.|..|.|        ..:|:.||
Worm   411 ACVKSTGINALW-----VARNRFAVLD---KAQNVSLR--------DLTNKELR----------- 448

  Fly   544 CSPSNLNVTATGKSEFVKAALDYRLHVSNGH--LKTQHGM----------LAKVTASDSKEMLW- 595
                        |.|.:..|:|...:...|.  |:...|:          .|.|..|..:.::|
Worm   449 ------------KLENINTAVDDIFYAGTGMLLLRNDDGLQLFDVQQKIVTASVKVSKVRYVIWS 501

  Fly   596 ---EFYV-----GSPLVNLNLCEKYAMLCSLDGSMRLISMETGCPVFPAISLTSSAVHCAFSPDN 652
               ||..     ...|||    .|..:||:...|.|   :::|.....::.|.:::.|..::.::
Worm   502 KSMEFAALLSKHTLTLVN----RKLEILCTQQESTR---VKSGAWDDDSVFLYTTSNHIKYAINS 559

  Fly   653 SLVGVLTECGLLRIWDIAKKVVSLAAGCLELLNKHGTAAQFSVTNQ------------------- 698
            .      :||::|..|:...::::....|..||:..|..:..:.|.
Worm   560 G------DCGIVRTLDLPLYILAIRGNVLYCLNRDATPVEVPIDNSDYKFKLALINKRIDEVVNM 618

  Fly   699 -------GMPLIGFPSGNSYSYSTSLQSWLVLATKDAIMYHGIR---GTLPRDMDQMQQ-----K 748
                   |..:||:.....|. ..:|.     ..||.....|:.   |.|...::..::     .
Worm   619 VRSANLVGQSIIGYLEKKGYP-EIALH-----FVKDEKTRFGLAIECGNLEIALEAAKKLDEPAV 677

  Fly   749 FPLLSMQASSQNYFSFTGSMELRHSESWQQCAKIRFI----ENQIKLCEALQSLDELQHWHKMLT 809
            :..|...|..|...... .|..:.::::::.:.:.|:    :..:|:.:..|:.:: .|.|
Worm   678 WEALGETALLQGNHQIV-EMSYQRTKNFEKLSFLYFVTGNTDKLVKMMKIAQARND-AHGH---- 736

  Fly   810 FQLA--THGSEKRMRVFLDDLLSMPEPGISQFVPKLELMQCVLDTLKPHSEWNRLHSEYTELLKE 872
            ||.|  |...|:|::|                     |..|...:|...:.....:|...|.||.
Worm   737 FQTALYTGDVEERVKV---------------------LRNCGQTSLAYLAAATHGYSAEAEELKA 780

  Fly   873 CKSERQKDI--------FATPAPPQQK-------TASSAGSSPRSGEATGEEVTEKDGATAVAAA 922
            ....||:.|        ...|.||..:       .||:.|:........|.:    ...|.|...
Worm   781 ELESRQQPIPPVDPNARLLVPPPPVARLEENWPLLASARGTFDAQLLGLGGQ----SAPTNVGGV 841

  Fly   923 VVAGSRMAVTTGTSTTTTTTASSS----LSSSGSSSSTSGSG---------------------SS 962
            ..|.:..||...........|...    :...|......|.|                     :.
Worm   842 KPAAAAFAVMDDDDGDVGNEAWGDDEYLVGEDGELDVDEGEGPVDGDEEGGWDVDDDLALPDVTD 906

  Fly   963 SSSSSTSSLSVPQPAPSLSPE 983
            ..........||.|||::|.|
Worm   907 DQGGDDDEEVVPNPAPAVSSE 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	70/319 (22%)
		WD40	14..349	CDD:238121	64/292 (22%)
		WD40 repeat	16..68	CDD:293791	1/5 (20%)
		WD40 repeat	74..127	CDD:293791	10/52 (19%)
		WD40 repeat	132..169	CDD:293791	10/36 (28%)
		WD40 repeat	176..211	CDD:293791	6/34 (18%)
		WD40 repeat	223..263	CDD:293791	8/39 (21%)
		WD40 repeat	275..322	CDD:293791	8/46 (17%)
		WD40 repeat	328..350	CDD:293791	5/21 (24%)
		HIRA_B	423..442	CDD:286531	6/22 (27%)
		Hira	629..820	CDD:284895	36/230 (16%)
copa-1	NP_491069.1	WD40	7..317	CDD:238121	73/344 (21%)
		WD40	14..503	CDD:225201	122/585 (21%)
		WD40 repeat	17..51	CDD:293791	1/5 (20%)
		WD40 repeat	57..93	CDD:293791	10/52 (19%)
		WD40 repeat	98..134	CDD:293791	10/36 (28%)
		WD40 repeat	141..204	CDD:293791	14/86 (16%)
		WD40 repeat	210..243	CDD:293791	11/52 (21%)
		WD40 repeat	254..288	CDD:293791	8/38 (21%)
		Coatomer_WDAD	341..770	CDD:281977	94/522 (18%)
		COPI_C	820..1227	CDD:284395	18/112 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910