DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and Hira

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_034565.2	Gene:	Hira / 15260	MGIID:	99430	Length:	1015	Species:	Mus musculus

Alignment Length:	1033	Identity:	385/1033 - (37%)
Similarity:	547/1033 - (52%)	Gaps:	187/1033 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLLKPAWVHHDDKQIFSVDIHKDCTKFATGGQGSDCGRVVIWNLLPVLSDKAEFDADVPKMLCQ 65
            |:||||.||:|:.|.|||||||.|.|||||||||.|.|:|||||:.|||.:..|.|.::||||||
Mouse     1 MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQ 65

  Fly    66 MDQHLACVNCVRWSQNGQNLASGSDDKLIMIWRKSA--GSSGVFGTGGMQKNHESWKCFYTLRGH 128
            ||.|||||||||||.:|..||||.||||||:|:::.  |.|.|||:.|...|.|.|:|...||.|
Mouse    66 MDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRSH 130

  Fly   129 DGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDD 193
            .|||:|:||||:|.:|||||:||||:||:|..||..:|||:||:|||||::|||:|:::|||:||
Mouse   131 SGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADD 195

  Fly   194 RSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKC 258
            ||:|:|.|::|.|..:||:||:|||||||:|||||||||.|||||||||..|||||||||||||.
Mouse   196 RSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKT 260

  Fly   259 DKDFVGHRKAVTCVRFHNSILSRQENDGSPSKP-LQYCCLAVGSRDRSLSVWMTALQRPMVVIHE 322
            :.||||||||||.|:|:..|..:::.:||.:|| ..|||.||||:|||||||:|.|:||:|||||
Mouse   261 NMDFVGHRKAVTVVKFNPKIFKKKQKNGSSTKPSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHE 325

  Fly   323 LFNASILDLTWGPQECLLMACSVDGSIACLKFTEEELGKAISEEEQNAIIRKMYGKN--YVNGLG 385
            ||:.||:|::|......::.||:|||:|.|.|:::|||..:||||::.|.:..|||:  .:....
Mouse   326 LFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQ 390

  Fly   386 KSAPVLEHPQRLLLPQGDKPTKFPLSN----------------NNEA----NQRPISKQTETRTK 430
            .|..|:|:|:.|...:..:..:....|                |.|:    .:..:.||.||||.
Mouse   391 LSTAVIENPEMLKYQRRQQQQQLDQKNATTRETSSASSVTGVVNGESLEDIRKNLLKKQVETRTA 455

  Fly   431 DGKRRITPMFIPLHEDG------------PTSLSMNIVSS-SGSSTTALTSCSAAIG-----TLP 477
            ||:|||||:.|...:.|            .:||:..::|| ||.....|.|.:.:.|     |.|
Mouse   456 DGRRRITPLCIAQLDTGDFSTAFFNSIPLSSSLAGTMLSSPSGQQLLPLDSSTPSFGASKPCTEP 520

  Fly   478 AAA------------------PTESAATPLMPLEPLVSKID-LGRLDSRLKTQPASQRRQSLPFD 523
            .||                  .|.:|::|.:...|  |||: :...|||.     ::|.::.|..
Mouse   521 VAATSARPTGESVSKDSMNATSTPAASSPSVLTTP--SKIEPMKAFDSRF-----TERSKATPGA 578

  Fly   524 PG------------QSNELLRTPRLEEHQSSTCS------------------------------- 545
            |.            :...|::..|..|.:||:.|
Mouse   579 PSLTSVIPTAVERLKEQNLVKELRSRELESSSDSDEKVHLAKPSSLSKRKLELEVETVEKKKKGR 643

  Fly   546 --------PSNLNVTATGKSEFVKAAL------------------DYRLHVSN---------GHL 575
                    |.:|:|.:.......|.|:                  .:.|.||:         ..:
Mouse   644 PRKDSRLLPMSLSVQSPAALSTEKEAMCLSAPALALKLPIPGPQRAFTLQVSSDPSMYIEVENEV 708

  Fly   576 KTQHGM-LAKVTAS-DSKEMLWEFYVGS-PLVNLNLCEKYAMLCSLDGSMRLISMETGC--PVFP 635
            .|..|: |:::..: :.||  ||..:.| .|.....|:...:.|    ..|::|:.:.|  .:.|
Mouse   709 TTVGGIRLSRLKCNREGKE--WETVLSSRVLTAAGSCDVVCVAC----EKRMLSVFSTCGRRLLP 767

  Fly   636 AISLTS--SAVHCAFSPDNSLVGVLTECGLLRIWDIAKKVVSLAAGCLE--LLNKHGTAAQFSVT 696
            .|.|.|  |.:||.    ...|..||....|.:||:.::||.:....|.  |.....|.:|..:|
Mouse   768 PILLPSPISTLHCT----GPYVMALTAAATLSVWDVHRQVVVVKEESLHSILSGSDMTVSQILLT 828

  Fly   697 NQGMPLIGFPSGNSYSYSTSLQSWLVLATKDAIMYH--GIRGTLPRDMDQMQQKFPLLSMQASSQ 759
            ..|:|::....|.:|.::.||.:|.:::.|...:..  ..|.:|| ..|.|....||..:|..:.
Mouse   829 QHGIPVMNLSDGKAYCFNPSLSTWNLVSDKQDSLAQCADFRNSLP-SQDAMLCSGPLAIIQGRTS 892

  Fly   760 NYFSFTGSMELR-----HSESWQQCAKIRFIENQIKLCEALQSLDELQHWHKMLTFQLATHGSEK 819
            |    :|....|     |..  ||...:.::|||:.....|||..|.:||..:....|...|.|.
Mouse   893 N----SGRQAARLFSVPHVV--QQETTLAYLENQVAAALTLQSSHEYRHWLLLYARYLVNEGFEY 951

  Fly   820 RMRVFLDDLLSMPEPGI-SQF------VPKLELMQCVLDTLKPHSEWNRLHSEYTELL 870
            |:|....|||....... ||:      :.|.||::.:|..:..:..:.||.:|..|.|
Mouse   952 RLREICKDLLGPVHCSTGSQWESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQL 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	226/360 (63%)
		WD40	14..349	CDD:238121	215/337 (64%)
		WD40 repeat	16..68	CDD:293791	36/51 (71%)
		WD40 repeat	74..127	CDD:293791	29/54 (54%)
		WD40 repeat	132..169	CDD:293791	23/36 (64%)
		WD40 repeat	176..211	CDD:293791	18/34 (53%)
		WD40 repeat	223..263	CDD:293791	32/39 (82%)
		WD40 repeat	275..322	CDD:293791	26/47 (55%)
		WD40 repeat	328..350	CDD:293791	8/21 (38%)
		HIRA_B	423..442	CDD:286531	13/18 (72%)
		Hira	629..820	CDD:284895	55/203 (27%)
Hira	NP_034565.2	WD40	<7..372	CDD:225201	229/367 (62%)
		WD40	7..352	CDD:238121	220/347 (63%)
		WD 1	11..53		29/41 (71%)
		WD40 repeat	16..61	CDD:293791	29/44 (66%)
		WD 2	68..107		25/40 (63%)
		WD40 repeat	74..129	CDD:293791	30/56 (54%)
		WD 3	129..168		24/38 (63%)
		WD40 repeat	134..171	CDD:293791	23/36 (64%)
		WD 4	172..211		21/38 (55%)
		WD40 repeat	178..213	CDD:293791	18/34 (53%)
		WD 5	220..263		35/42 (83%)
		WD40 repeat	226..265	CDD:293791	32/38 (84%)
		WD 6	266..322		33/56 (59%)
		WD40 repeat	273..324	CDD:293791	29/51 (57%)
		WD 7	326..367		17/40 (43%)
		WD40 repeat	331..354	CDD:293791	8/22 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..431		9/42 (21%)
		Interaction with CCNA1. /evidence=ECO:0000250	421..727		96/429 (22%)
		Interaction with ASF1A. /evidence=ECO:0000250	421..479		26/75 (35%)
		Required for repression of histone gene transcription. /evidence=ECO:0000250	439..475		11/53 (21%)
		HIRA_B	448..469	CDD:286531	7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..558		19/115 (17%)
		Interaction with PAX3. /evidence=ECO:0000269\|PubMed:9731536	593..737		38/152 (25%)
		Interaction with histone H2B. /evidence=ECO:0000250	594..824		65/243 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..623		3/19 (16%)
		Interaction with histone H4. /evidence=ECO:0000250	736..1015		41/147 (28%)
		Interaction with PAX3. /evidence=ECO:0000269\|PubMed:9731536	738..826		27/92 (29%)
		Hira	761..952	CDD:284895	33/122 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842050
Domainoid	1	1.000	68	1.000	Domainoid score	I9744
eggNOG	1	0.900	-	-		E1_KOG0973
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48172
Inparanoid	1	1.050	624	1.000	Inparanoid score	I868
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D366817at33208
OrthoFinder	1	1.000	-	-		FOG0003162
OrthoInspector	1	1.000	-	-		oto92117
orthoMCL	1	0.900	-	-		OOG6_103167
Panther	1	1.100	-	-	LDO	PTHR13831
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R561
SonicParanoid	1	1.000	-	-		X3052
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790