DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hira and WDSUB1

DIOPT Version :9

Sequence 1:NP_572401.2 Gene:Hira / 31680 FlyBaseID:FBgn0022786 Length:1047 Species:Drosophila melanogaster
Sequence 2:NP_001121684.1 Gene:WDSUB1 / 151525 HGNCID:26697 Length:476 Species:Homo sapiens


Alignment Length:512 Identity:101/512 - (19%)
Similarity:169/512 - (33%) Gaps:194/512 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 HDDKQIFSVDIHKDCTKFATGG----QGSDCGRVVIWN-----LLPVLSDKAEFDADVPKMLCQM 66
            |...:..:..:|  |..|:..|    ..|..|..|:||     :|.|:    |..:..|..:||.
Human    47 HSPLKFHTYAVH--CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVM----EQPSGSPVRVCQF 105

  Fly    67 DQHLACVNCVRWSQNGQNLASGSDDKLIMIWRKSA----------------------GSSGVFGT 109
            .....|            ||||:.|..:::|...:                      ||..|.|:
Human   106 SPDSTC------------LASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGS 158

  Fly   110 --GGMQKNHESWKCFYTLRGHDGDVLDLAWSPNDV----------YLASCSIDNTVIIWDAQAFP 162
              |.:....:..:|.::.:.||..:....:|...|          .||||..|..|.|| ..:|.
Human   159 SCGDLTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW-IVSFT 222

  Fly   163 HSV-------ATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITEPFEECGGT 220
            |.:       :||.||...|...::...|:.|.|.|.|:|:.:::|...::.||:|:        
Human   223 HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQ-------- 279

  Fly   221 THILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKCDKDFVGHRKAVTCVRFHNSILSRQEND 285
                              |.                         |...||....|::|      
Human   280 ------------------HT-------------------------RYVTTCAFAPNTLL------ 295

  Fly   286 GSPSKPLQYCCLAVGSRDRSLSVW---MTALQRPMVVIHEL--FNASILDLTWGPQECLLMAC-- 343
                       ||.||.|:::::|   :..|.:.....|:|  |...     |..::.....|  
Human   296 -----------LATGSMDKTVNIWQFDLETLCQARRTEHQLKQFTED-----WSEEDVSTWLCAQ 344

  Fly   344 ------------SVDGSIACLKFTEEELGKAISEEE---QNAIIRKMYG-----KNYVNGLGKSA 388
                        ::||. ..|..|:|.|...:..|.   ::.::||:..     |:..:|:    
Human   345 DLKDLVGIFKMNNIDGK-ELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGI---- 404

  Fly   389 PVLEHPQRLLLPQGDKPTKFPL------SNNNEANQRPISKQTETRTKDGKRRITPM 439
                 |...:.|...:..|.|:      |...||.:..|||         |:|.:||
Human   405 -----PDEFICPITRELMKDPVIASDGYSYEKEAMENWISK---------KKRTSPM 447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HiraNP_572401.2 WD40 <12..370 CDD:225201 82/429 (19%)
WD40 14..349 CDD:238121 77/403 (19%)
WD40 repeat 16..68 CDD:293791 15/60 (25%)
WD40 repeat 74..127 CDD:293791 12/76 (16%)
WD40 repeat 132..169 CDD:293791 13/53 (25%)
WD40 repeat 176..211 CDD:293791 9/34 (26%)
WD40 repeat 223..263 CDD:293791 1/39 (3%)
WD40 repeat 275..322 CDD:293791 9/49 (18%)
WD40 repeat 328..350 CDD:293791 4/35 (11%)
HIRA_B 423..442 CDD:286531 5/17 (29%)
Hira 629..820 CDD:284895
WDSUB1NP_001121684.1 WD40 <2..308 CDD:225201 69/347 (20%)
WD40 4..309 CDD:238121 69/348 (20%)
WD 1 10..47 101/512 (20%)
WD40 repeat 16..52 CDD:293791 1/4 (25%)
WD 2 52..91 10/40 (25%)
WD40 repeat 57..93 CDD:293791 11/41 (27%)
WD 3 95..134 10/50 (20%)
WD40 repeat 101..135 CDD:293791 9/45 (20%)
WD 4 137..176 6/38 (16%)
WD40 repeat 142..177 CDD:293791 6/34 (18%)
WD 5 178..228 14/50 (28%)
WD40 repeat 183..236 CDD:293791 13/53 (25%)
WD 6 237..276 10/38 (26%)
WD40 repeat 242..266 CDD:293791 7/23 (30%)
WD 7 279..318 13/106 (12%)
WD40 repeat 284..326 CDD:293791 12/58 (21%)
SAM_WDSUB1 328..399 CDD:188904 12/76 (16%)
SAM 332..395 CDD:197735 11/63 (17%)
U-box 404..476 CDD:252675 14/62 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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