DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and AgaP_AGAP012029

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	XP_320491.4	Gene:	AgaP_AGAP012029 / 1280633	VectorBaseID:	AGAP012029	Length:	378	Species:	Anopheles gambiae

Alignment Length:	382	Identity:	89/382 - (23%)
Similarity:	152/382 - (39%)	Gaps:	95/382 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 LRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLK--GHTGLVKGVSWDPLGRFL 187
            |:||.|.:..|:::|......:.|.|::.|:|...   ..|..::  .||.:|..|.|.|.||.:
Mosquito    10 LKGHRGKLTGLSFNPEGTRFVTSSTDHSAIVWTNN---EQVRCMRFEAHTDVVNDVCWSPDGRII 71

  Fly   188 ASQSDDRSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIE 252
            ::.|.|||:|||      :...:....|..|.|:::..:.:.|.|:.|::|    ....|.::
Mosquito    72 STVSKDRSVKIW------VPSMLGNSDEFRGHTSNVRSVDFDPTGKKLLTA----SDDKTVKL-- 124

  Fly   253 REGWKCDK-----DFVGHRKAVTCVRFHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLSVWMTA 312
               ||..:     .|.||...|.|.||            ||:..|...|    ..||:|.::..|
Mosquito   125 ---WKVSRKQFLSSFTGHTNWVRCARF------------SPNGKLIASC----GDDRTLKLFDPA 170

  Fly   313 LQRPMVVIHELFN--ASILDLTWGPQECLLMACSVDGSIAC-LKFTEEELGKAISEEEQNAIIRK 374
            ..:   .:|..::  .:...:.|.| :..|:|.::|.   | :|..:..:.|.|
Mosquito   171 TGQ---CVHSFYDQKGAGCKVAWHP-DSTLVAIALDN---CRVKIFDINIRKLI----------- 217

  Fly   375 MYGKNY---VNGLGKSAPVLEHP--QRLLLPQGDKPTK----------FPLSNNNEANQRPISKQ 424
            .|.:.|   ||.|.      .||  ..|:....|..||          |.|:    .::.|::
Mosquito   218 QYYRIYDGPVNSLD------FHPSGNYLITGSDDGVTKIIDLLEGRQIFTLT----GHRGPVT-- 270

  Fly   425 TETRTKDGKRRITPMFIPLHEDGPTSL-SMNIVSSSGSSTTALTSCSAAIGTLPAAA 480
            |...:|||:     :|....:|....| ..|:.:.|..::......|:...|.|||:
Mosquito   271 TVKFSKDGQ-----LFATGSDDCHVMLWKANLDNDSAQNSLYTPEGSSCESTHPAAS 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	61/254 (24%)
		WD40	14..349	CDD:238121	57/232 (25%)
		WD40 repeat	16..68	CDD:293791
		WD40 repeat	74..127	CDD:293791	1/1 (100%)
		WD40 repeat	132..169	CDD:293791	7/36 (19%)
		WD40 repeat	176..211	CDD:293791	12/34 (35%)
		WD40 repeat	223..263	CDD:293791	7/44 (16%)
		WD40 repeat	275..322	CDD:293791	8/46 (17%)
		WD40 repeat	328..350	CDD:293791	5/21 (24%)
		HIRA_B	423..442	CDD:286531	5/18 (28%)
		Hira	629..820	CDD:284895
AgaP_AGAP012029	XP_320491.4	WD40	8..294	CDD:238121	82/352 (23%)
		WD40	10..312	CDD:225201	84/370 (23%)
		WD40 repeat	17..54	CDD:293791	7/39 (18%)
		WD40 repeat	60..96	CDD:293791	13/41 (32%)
		WD40 repeat	101..137	CDD:293791	7/44 (16%)
		WD40 repeat	144..179	CDD:293791	12/53 (23%)
		WD40 repeat	186..219	CDD:293791	9/47 (19%)
		WD40 repeat	227..263	CDD:293791	10/41 (24%)
		WD40 repeat	269..293	CDD:293791	6/30 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910