DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and AgaP_AGAP008908

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	XP_319655.2	Gene:	AgaP_AGAP008908 / 1279875	VectorBaseID:	AGAP008908	Length:	374	Species:	Anopheles gambiae

Alignment Length:	454	Identity:	77/454 - (16%)
Similarity:	141/454 - (31%)	Gaps:	180/454 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 VNCVRWSQNGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAW 137
            :.|..|:::...:|...::..:.|:::         ||      ..||....|..||..|:.:.|
Mosquito    14 ITCHAWNKDRSQIAISPNNNEVHIYKR---------TG------SEWKLTDVLNQHDLRVMGIDW 63

  Fly   138 SPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTM 202
            :||...:.:|::|....:|           .:|..|     .|.|
Mosquito    64 APNTNRIVTCAVDRNAYVW-----------TQGDDG-----KWKP-------------------- 92

  Fly   203 NWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKCDKDFVGHRK 267
                             |..:||::                                       :
Mosquito    93 -----------------TLVLLRIN---------------------------------------R 101

  Fly   268 AVTCVRFHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLSV---------WMTA-LQRPMVVIHE 322
            |.||||:     |..||.           .||||..|.:||         |::. :::|:
Mosquito   102 AATCVRW-----SPLENK-----------FAVGSGARLISVCYFESENDWWVSKHIKKPI----- 145

  Fly   323 LFNASILDLTWGPQECLLMACSVDGSI----ACLKFTEEE-----------LGKAISEEEQNAII 372
              .:::..|.|.|...||:|.|.|..:    |.:|..|:.           ||:.::|.:.::.
Mosquito   146 --RSTVTSLDWHPNNMLLVAGSTDYKVRVFSAFIKDIEQHPEPTAWGPKKPLGQILAEFKNSST- 207

  Fly   373 RKMYGKNYVNGLGKSAPVLEHPQRLLLPQGDKPTKFPLSNNNEANQRPISKQTE----------- 426
                |..:|:.:..||    ...|:.....|......::|.....   :.::||
Mosquito   208 ----GGGWVHSVSFSA----DGNRICWVGHDSAINIGMANGGNVT---VKQKTEYLPFLCCEWIS 261

  Fly   427 -TRTKDGKRRITPMFIPLHEDGPTSLSMNIVSSSGSSTTALTSCSAAIGTLPAAAPTESAATPL 489
             ...........|:...:.|||...|:..:..|:....:.: |......:|.....||::.|.|
Mosquito   262 PQSILVAGHSCVPLIYTVGEDGKVVLAAKLDQSTKKEQSGI-SAMRIFQSLDRNLRTENSDTNL 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	56/321 (17%)
		WD40	14..349	CDD:238121	50/285 (18%)
		WD40 repeat	16..68	CDD:293791
		WD40 repeat	74..127	CDD:293791	9/52 (17%)
		WD40 repeat	132..169	CDD:293791	7/36 (19%)
		WD40 repeat	176..211	CDD:293791	2/34 (6%)
		WD40 repeat	223..263	CDD:293791	2/39 (5%)
		WD40 repeat	275..322	CDD:293791	12/56 (21%)
		WD40 repeat	328..350	CDD:293791	8/25 (32%)
		HIRA_B	423..442	CDD:286531	3/30 (10%)
		Hira	629..820	CDD:284895
AgaP_AGAP008908	XP_319655.2	WD40	<3..235	CDD:295369	62/359 (17%)
		WD40 repeat	14..53	CDD:293791	9/53 (17%)
		WD40	<15..235	CDD:225201	62/358 (17%)
		WD40 repeat	59..97	CDD:293791	11/90 (12%)
		WD40 repeat	103..142	CDD:293791	15/54 (28%)
		WD40	146..>364	CDD:295369	35/192 (18%)
		WD40 repeat	150..205	CDD:293791	14/54 (26%)
		WD40 repeat	212..246	CDD:293791	6/40 (15%)
		WD40 repeat	254..292	CDD:293791	5/37 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910