DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and CIAO1_ANOGA

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	XP_310648.3	Gene:	CIAO1_ANOGA / 1271794	VectorBaseID:	AGAP000444	Length:	341	Species:	Anopheles gambiae

Alignment Length:	397	Identity:	96/397 - (24%)
Similarity:	146/397 - (36%)	Gaps:	111/397 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RLLKPAWVHHDDKQIFSVDIHKDCTKFATGGQGSDCGR---VVIWNLLPVLSDKAEFDADVPKML 63
            |:...||  |...::|                 :.||.   :.:||       |::.|..|.:.:
Mosquito    16 RVWSAAW--HPGGKLF-----------------ASCGEDKTIRVWN-------KSDTDRWVAQTV 54

  Fly    64 CQMDQHLACVNCVRWSQNGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGH 128
            . .|.|...:..:.||..|..|||.|.|..:.:|.|.:|               .::|..||.||
Mosquito    55 L-TDGHTRTIRELAWSCCGHYLASASFDTTVAVWDKKSG---------------EFECNATLEGH 103

  Fly   129 DGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFP------HSVATLKGHTGLVKGVSWDPLGRFL 187
            |.:|..:.||.:...||:||.|.:|.||:....|      ..||.|.|||..||.|.|.|....|
Mosquito   104 DNEVKSVTWSRSGNLLATCSRDKSVWIWEIHHAPDQEDEYECVAVLNGHTQDVKKVCWHPQEDLL 168

  Fly   188 ASQSDDRSIKIWN----TMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTA 248
            ||.|.|.:|:::.    ...|.:    .||.|....|  :..:|:...||.|.|.    ....|.
Mosquito   169 ASASYDNTIRMYRQDLADSEWEM----LEPLESHSST--VWSISFDATGQRLASC----SEDTTV 223

  Fly   249 QIIEREG---------------WKCDKDFVGHRKAVTCVRFHNSILSRQENDGSPSKPLQYC--- 295
            ::.::.|               |||         ..|...:|    ||...|      :.:|
Mosquito   224 KVWQQYGPDNALGIPCPDRGTIWKC---------VCTLSGYH----SRSVYD------IDWCKQT 269

  Fly   296 -CLAVGSRDRSLSVWMTALQR-------PMVVIHELFNASILDLTWGPQ-ECLLMACSVDGSIAC 351
             .||....|.::.::..|...       .:||..|..:.....:.|.|. ..||:..|.||.|..
Mosquito   270 GLLATACGDDTVRIFREASDSDRNEPTFELVVTVEAHSQDANKVAWHPTVPGLLLTASDDGEIKL 334

  Fly   352 LKFTEEE 358
            .::.:.:
Mosquito   335 WQYVDAD 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	92/387 (24%)
		WD40	14..349	CDD:238121	91/374 (24%)
		WD40 repeat	16..68	CDD:293791	8/54 (15%)
		WD40 repeat	74..127	CDD:293791	14/52 (27%)
		WD40 repeat	132..169	CDD:293791	14/42 (33%)
		WD40 repeat	176..211	CDD:293791	11/38 (29%)
		WD40 repeat	223..263	CDD:293791	10/54 (19%)
		WD40 repeat	275..322	CDD:293791	11/57 (19%)
		WD40 repeat	328..350	CDD:293791	7/22 (32%)
		HIRA_B	423..442	CDD:286531
		Hira	629..820	CDD:284895
CIAO1_ANOGA	XP_310648.3	WD40	<2..335	CDD:225201	96/389 (25%)
		WD40	6..336	CDD:238121	96/390 (25%)
		WD40 repeat	17..58	CDD:293791	11/67 (16%)
		WD40 repeat	64..102	CDD:293791	14/52 (27%)
		WD40 repeat	107..150	CDD:293791	14/42 (33%)
		WD40 repeat	157..196	CDD:293791	13/42 (31%)
		WD40 repeat	202..253	CDD:293791	11/63 (17%)
		WD40 repeat	260..304	CDD:293791	8/49 (16%)
		WD40 repeat	311..335	CDD:293791	8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910