Protein Alignment Hira and Hira

DIOPT Version :10

• Sequence 1: NP_572401.2
• Gene: Hira / 31680
• FlyBaseID: FBgn0022786
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_061511662.1
• Gene: Hira / 1271422
• VectorBaseID: AGAMI1_003499
• Length: 952
• Species: Anopheles gambiae
• Alignment Length: 966
• Identity: 463/966 - (47%)
• Similarity: 607/966 - (62%)
• Gaps: 118/966 - (12%)

  Fly     1 MRLLKPAWVHHDDKQIFSVDIHKDCTKFATGGQGSDCGRVVIWNLLPVLSDKAEFDADVPKMLCQ 65
            |::.:|.|||||:|.|||:|||....:|||||||.|.|||||||:.||||::||.:..||::|||
Mosquito     1 MKIFQPNWVHHDEKSIFSIDIHPSGERFATGGQGCDSGRVVIWNMAPVLSEQAEANKSVPRVLCQ 65

  Fly    66 MDQHLACVNCVRWSQNGQNLASGSDDKLIMIWRK----SAGSSGVFGTGGMQKNHESWKCFYTLR 126
            ||.|||||||||||.||..||||.||||:|||:|    |.|..|.||.|| .|:.|.|:|..|||
Mosquito    66 MDNHLACVNCVRWSGNGLMLASGGDDKLVMIWKKTLSGSGGGIGAFGGGG-GKSVEHWRCISTLR 129

  Fly   127 GHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQS 191
            ||.||||||||||.|.::||||:|||:|:||||.||..|..|||||||||||:|||:|:|:||||
Mosquito   130 GHAGDVLDLAWSPQDRWIASCSVDNTIIVWDAQQFPKIVHVLKGHTGLVKGVTWDPVGKFVASQS 194

  Fly   192 DDRSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGW 256
            ||||:|:|.|.:||...|||||||||||||||||||||||||||||||||||||||||||||:||
Mosquito   195 DDRSLKVWKTTDWSCFKTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIERDGW 259

  Fly   257 KCDKDFVGHRKAVTCVRFHNSILSRQENDGSP--SKPLQYCCLAVGSRDRSLSVWMTALQRPMVV 319
            |||||||||||||||||||||||.|    .:|  :|..||||||||:||||||:|:||||||:||
Mosquito   260 KCDKDFVGHRKAVTCVRFHNSILKR----SAPKTNKLQQYCCLAVGARDRSLSIWLTALQRPLVV 320

  Fly   320 IHELFNASILDLTWGPQECLLMACSVDGSIACLKFTEEELGKAISEEEQNAIIRKMYGKN----- 379
            ||:||..|||||:|......|:.||.||.||||:||.:|||..:|||::|.:.::|||||
Mosquito   321 IHDLFQDSILDLSWSCDGYTLLTCSGDGHIACLQFTAQELGTPLSEEDKNILYQRMYGKNANIDL 385

  Fly   380 --------------YVNGLGKSAPV-------LEHPQ----------RLLLPQGDKPTKFPLSNN 413
                          ::| :.||.|:       .:.||          :::.| ..:|.....|::
Mosquito   386 TAQAEKEMIVENSDFLN-VSKSNPLPPTLIPQQQQPQLGGMRQDGAGKVVQP-ASQPAAAIKSSS 448

  Fly   414 NEANQRPISKQTETRTKDGKRRITPMFIPLHED-GPTSLSMNIVSSSGSSTTALTSCSAAIGTLP 477
            :.|...||.||.||:|.|||||||||||||::| ||.|.:.|.:.   .|:....|.|:...|:.
Mosquito   449 SLAAPTPILKQIETKTADGKRRITPMFIPLNDDNGPASHATNNIM---PSSIEFGSKSSETSTVE 510

  Fly   478 AAAPTESAATPLMPLEPLVSKIDLGRLDSRLK----TQPASQRRQSLPFDP-GQSNELLRTPRLE 537
            .........|.:.|.....:.....:||:|||    ..|......::|.|| .|..:.|..|
Mosquito   511 IKQRAHEEPTIIPPPAERATGEPTSKLDNRLKKMATAPPQKAEPMTVPTDPQQQQQQQLSAP--- 572

  Fly   538 EHQSSTCSP-SNLNVT---------ATGKSEFV-----KAALDYRLHVSNGHLKTQHGMLAK--- 584
               |||..| :|..:.         .|||:..:     ||..:.|:.:.|..:||.:|.|::
Mosquito   573 ---SSTIQPAANQKLMDRTRQPATYPTGKATVIQGHSFKAFGEVRVQIQNNTVKTSYGTLSRVVG 634

  Fly   585 --VTASDSKEMLWEFYVGSPLVNLNLCEKYAMLCSLDGSMRLISMETGCPVFPAISLTSSAVHCA 647
              |||...:..|||..||||:|...:..|||::||.|.::|::.::||.||||.:||||.||..|
Mosquito   635 VVVTAQRVERKLWETVVGSPIVCFAVGAKYAIVCSQDHTIRMVDIKTGTPVFPVLSLTSPAVLSA 699

  Fly   648 FSPDNSLVGVLTECGLLRIWDIAKKVVSLAAGCLELLNKHGT-AAQFSVTNQGMPLIGFPSGNSY 711
            ||.::.|.||:||.|:||||.:.:|.|.|:..|.|:::  |: .....|:::|||.|...:|:||
Mosquito   700 FSSNSQLAGVVTESGILRIWSVPEKAVLLSTSCAEIMS--GSFVTILHVSDKGMPFIVLSNGSSY 762

  Fly   712 SYSTSLQSWLVLATKDAIMYHGIRGTLPRDMDQMQQKFPLLSMQASSQNYFSFTG----SMELRH 772
            ||...|.||:::.:.|.::.||:.|.......:..:.:||    ::.|:|.||:|    |....|
Mosquito   763 SYCRKLDSWMLINSSDPVIRHGLIGNKTNAPVRNIKTYPL----STIQSYGSFSGPKTNSFAELH 823

  Fly   773 SESWQQCAKIRFIENQIKLCEALQSLDELQHWHKMLTFQLATHGSEKRMRVFLDDLLSMP----E 833
            |.|||..|.|.|||||||:||.:.|..||::|:.||.||||.:|||:::|..|||||...    :
Mosquito   824 SASWQTSAAIAFIENQIKICEMIASPAELKYWYSMLGFQLALNGSEEKIRQVLDDLLGASHNSLD 888

  Fly   834 P---------------GISQFVPKLELMQCVLDTLKPHSEWNRLHSEYTELLKECK 874
            |               |||    |..||:.||:.||..::|.|:::||.:.||..|
Mosquito   889 PCRTLAGDDADDRSVLGIS----KQLLMEDVLNHLKTQTKWQRIYTEYLDQLKFLK 940

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	14..349	CDD:238121	242/340 (71%)
		WD40 repeat	16..68	CDD:293791	33/51 (65%)
		WD40 repeat	74..127	CDD:293791	33/56 (59%)
		WD40 repeat	132..169	CDD:293791	24/36 (67%)
		WD40 repeat	176..211	CDD:293791	22/34 (65%)
		WD40 repeat	223..263	CDD:293791	38/39 (97%)
		WD40 repeat	275..322	CDD:293791	32/48 (67%)
		WD40 repeat	328..350	CDD:293791	10/21 (48%)
		HIRA_B	424..442	CDD:462802	14/17 (82%)
		Hira	630..828	CDD:462211	87/202 (43%)
Hira	XP_061511662.1	None