DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and AgaP_AGAP007544

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	XP_308335.3	Gene:	AgaP_AGAP007544 / 1269690	VectorBaseID:	AGAP007544	Length:	741	Species:	Anopheles gambiae

Alignment Length:	625	Identity:	162/625 - (25%)
Similarity:	249/625 - (39%)	Gaps:	136/625 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AWVHHDDKQIFSVDI---------HKDCTKFATGGQGSDCGRVVIWNLLPVL---SDKAEFDADV 59
            :|  |:...:.||||         |:  .:.|:||..|   .|:||.::...   :...|..||
Mosquito     9 SW--HNRDPVLSVDIQPKGANDRDHQ--YRLASGGTDS---HVLIWYMIQTPECGTINLELAAD- 65

  Fly    60 PKMLCQMDQHLACVNCVRWSQNGQNLASGSDDKLIMIWRKSAGSSGVF----GTGGMQKNHESWK 120
                  :.:|...||.||||.:|:.||||.|:.:|.|| |..|.:...    .|....|  |:|.
Mosquito    66 ------LTRHQRAVNAVRWSPSGELLASGDDESVIFIW-KQKGETETLNILENTNDQDK--ETWL 121

  Fly   121 CFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGR 185
            ....||||..||.||:||.|..:|.|.|:||:.|:||.|. ..:.|.|:.|.|.|:||:|||..:
Mosquito   122 TMKILRGHMEDVYDLSWSANSQFLISGSVDNSAIVWDVQR-GKNTAILQDHKGFVQGVAWDPQNK 185

  Fly   186 FLASQSDDRSIKIWNTMN---WSLSHTITEP--------------FEECGGTTHILRLSWSPDGQ 233
            :||:.|.||..::::...   .|..|....|              :.:....|...|||:||||.
Mosquito   186 YLATLSTDRYFRVYDVQTKRVVSRCHKCVLPVPKEHPLRDKTIRLYHDDTLQTFFRRLSFSPDGN 250

  Fly   234 YLVSAHAM----NGGGP--TAQIIEREGWKCDKDFV--GHRKAVTCVRFHNSILSRQENDGS--P 288
            .:|:...|    ....|  |..|..|...| ...|.  ...:....|||.......:.:..|  |
Mosquito   251 IIVTPSGMAEIEGVSKPLNTTYIFTRNSLK-QPSFTLPSPDQYTVAVRFCPVYFQHRPHAESKPP 314

  Fly   289 SKPLQYCCLAVGSRDRSLSVWMTALQRPMVVIHELFNASILDLTWGPQECLLMACSVDGSIACLK 353
            ..||.|..:...:...|:.::.|....|..:|..:....:.|::|.....:|:..|.||..:.:.
Mosquito   315 LVPLPYRMVFAVATKSSVYLYDTQQAAPFALISNIHYTRLTDMSWSSDGRILIVSSTDGFCSMIF 379

  Fly   354 FTEEELG--------KAISEEEQNAIIRKMYGKNYVNGLGKSAPVLEHPQRLLLPQGDKPTKFPL 410
            |:|.|||        :|.:.:|.:...:....|.  :...||.|..:..|       |||.: |:
Mosquito   380 FSEGELGTIWEPPSPEASAADEPSTSSKADETKR--DDDSKSTPPPKEKQ-------DKPAQ-PI 434

  Fly   411 SNNNEANQRPISKQTETRTK------DGKRRITPMFIPLHEDGPTSLSMNIVSSSGSSTTALTSC 469
            :    ..::|..::|.|.:|      |.....||.  |..:|.
Mosquito   435 A----FRRKPKPEETSTPSKADEIIIDDDSNSTPP--PQKDDN---------------------- 471

  Fly   470 SAAIGTLPAAAPTESAATPL------MPLEPLV-SKIDLGRLDSRLKTQPASQRRQSLPFD-PGQ 526
                |..|:   :|....|:      .|.||.. .|.|..::|...::.|..:...|...| |.|
Mosquito   472 ----GKKPS---SEKPPQPIAIRRKPKPEEPKTPPKADEMKMDDGSESTPPEKDDTSKKQDKPAQ 529

  Fly   527 SNELLRTPRLEEHQSST------CSPSNLNVTATGKSEFV 560
            ...:.|.|:.||.:.:|      .||:...:...| .|||
Mosquito   530 PIAIRRKPKPEEPKPTTSEGAVVVSPTVEKIVQPG-VEFV 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	116/408 (28%)
		WD40	14..349	CDD:238121	109/377 (29%)
		WD40 repeat	16..68	CDD:293791	15/63 (24%)
		WD40 repeat	74..127	CDD:293791	21/56 (38%)
		WD40 repeat	132..169	CDD:293791	16/36 (44%)
		WD40 repeat	176..211	CDD:293791	12/37 (32%)
		WD40 repeat	223..263	CDD:293791	14/45 (31%)
		WD40 repeat	275..322	CDD:293791	9/48 (19%)
		WD40 repeat	328..350	CDD:293791	6/21 (29%)
		HIRA_B	423..442	CDD:286531	6/24 (25%)
		Hira	629..820	CDD:284895
AgaP_AGAP007544	XP_308335.3	WD40	13..300	CDD:295369	94/303 (31%)
		WD40	66..473	CDD:225201	119/453 (26%)
		WD40 repeat	74..128	CDD:293791	21/56 (38%)
		WD40 repeat	133..169	CDD:293791	16/36 (44%)
		WD40 repeat	176..209	CDD:293791	10/32 (31%)
		WD40 repeat	240..287	CDD:293791	15/47 (32%)
		WD40 repeat	295..346	CDD:293791	11/50 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D366817at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920