DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and ARPC1A

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_006400.2	Gene:	ARPC1A / 10552	HGNCID:	703	Length:	370	Species:	Homo sapiens

Alignment Length:	170	Identity:	37/170 - (21%)
Similarity:	71/170 - (41%)	Gaps:	26/170 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 VNCVRWSQNGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAW 137
            :.|..|:::...:|...::..:.|::|: ||..|       |.||       |:.|:|.:..:.|
Human    11 ITCHAWNRDRTQIALSPNNHEVHIYKKN-GSQWV-------KAHE-------LKEHNGHITGIDW 60

  Fly   138 SPNDVYLASCSIDNTVIIWDAQ--AFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIW- 199
            :|....:.:|..|....:|..:  .:..::..|:.:.. ...|.|.||....|..|..|.|.:.
Human    61 APKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRA-ATFVKWSPLENKFAVGSGARLISVCY 124

  Fly   200 --NTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVS 237
              :..:|.:|..|.:|..     :.:|.|.|.|:...|.:
Human   125 FESENDWWVSKHIKKPIR-----STVLSLDWHPNNVLLAA 159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	37/170 (22%)
		WD40	14..349	CDD:238121	37/170 (22%)
		WD40 repeat	16..68	CDD:293791
		WD40 repeat	74..127	CDD:293791	12/52 (23%)
		WD40 repeat	132..169	CDD:293791	5/38 (13%)
		WD40 repeat	176..211	CDD:293791	10/37 (27%)
		WD40 repeat	223..263	CDD:293791	5/15 (33%)
		WD40 repeat	275..322	CDD:293791
		WD40 repeat	328..350	CDD:293791
		HIRA_B	423..442	CDD:286531
		Hira	629..820	CDD:284895
ARPC1A	NP_006400.2	WD 1	6..45		8/41 (20%)
		WD40	<9..80	CDD:421866	18/83 (22%)
		WD40 repeat	11..50	CDD:293791	12/53 (23%)
		WD40	46..>288	CDD:421866	28/127 (22%)
		WD 2	50..89		7/38 (18%)
		WD40 repeat	56..93	CDD:293791	5/36 (14%)
		WD40 repeat	98..138	CDD:293791	10/40 (25%)
		WD 3	140..179		6/25 (24%)
		WD40 repeat	146..199	CDD:293791	5/14 (36%)
		WD 4	202..241
		WD40 repeat	207..243	CDD:293791
		WD 5	244..284
		WD40 repeat	249..287	CDD:293791
		WD 6	322..365
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910