Protein Alignment Hira and hira

DIOPT Version :9

• Sequence 1: NP_572401.2
• Gene: Hira / 31680
• FlyBaseID: FBgn0022786
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_002931950.2
• Gene: hira / 100495450
• XenbaseID: XB-GENE-976072
• Length: 1011
• Species: Xenopus tropicalis
• Alignment Length: 1031
• Identity: 390/1031 - (37%)
• Similarity: 546/1031 - (52%)
• Gaps: 187/1031 - (18%)

  Fly     1 MRLLKPAWVHHDDKQIFSVDIHKDCTKFATGGQGSDCGRVVIWNLLPVLSDKAEFDADVPKMLCQ 65
            |:||||.||:|:.|.|||||||.|.|||||||||.|.|:|||||:.|:|.::.|.:.::||||||
 Frog     1 MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMPPLLKEEDEKNENIPKMLCQ 65

  Fly    66 MDQHLACVNCVRWSQNGQNLASGSDDKLIMIWRKSA--GSSGVFGTGGMQKNHESWKCFYTLRGH 128
            ||.|||||||||||.:|..||||.||||||:|::|.  |.|.|||:.....|.|.|:|...||.|
 Frog    66 MDNHLACVNCVRWSNSGAYLASGGDDKLIMVWKRSGYIGPSTVFGSSSKLANVEQWRCLSILRSH 130

  Fly   129 DGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDD 193
            .|||:|::|||:|.:|||||:||||:||:|..||..::||:||:|||||::|||:|:::|||:||
 Frog   131 SGDVMDVSWSPHDAWLASCSVDNTVVIWNALKFPEIISTLRGHSGLVKGLTWDPVGKYIASQADD 195

  Fly   194 RSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKC 258
            ||||:|.||:|.|..:||:||:|||||||:|||||||||.|||||||||..|||||||||:|||.
 Frog   196 RSIKVWRTMDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIERDGWKA 260

  Fly   259 DKDFVGHRKAVTCVRFHNSILSRQENDGSPSKP-LQYCCLAVGSRDRSLSVWMTALQRPMVVIHE 322
            :.||||||||||.|:|:..|..:::.:||.:|. ..|||.||||:|||||||:|.|:||:|||||
 Frog   261 NMDFVGHRKAVTVVKFNPKIFKKKQKNGSSTKTNCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHE 325

  Fly   323 LFNASILDLTWGPQECLLMACSVDGSIACLKFTEEELGKAISEEEQNAIIRKMYGKN--YVNGLG 385
            ||:.||:|::|......::.||:|||:|.|.|:::|||..:||||:|.|.:..|||:  ......
 Frog   326 LFDKSIMDISWTLNGLGILVCSMDGSVAYLDFSQDELGDPLSEEEKNNIHQTTYGKSLAITTEPQ 390

  Fly   386 KSAPVLEHPQRLLLPQGDKP-----------TKFPLSN-----NNEA----NQRPISKQTETRTK 430
            .|..|:|:|:.|...|..:|           .:.|..|     |.|:    .:..:.||.||||.
 Frog   391 LSNTVIENPEMLKFQQRQQPHQDGEHRVQAQREAPAHNVASMVNGESLEDIRKNLLKKQVETRTA 455

  Fly   431 DGKRRITPMFIPLHEDGP----------------------------TSLSMNIVSSSGSSTTALT 467
            ||:|||||:.|...:.|.                            .||..|..||||:..   :
 Frog   456 DGRRRITPLCIAQLDTGDFSTAFFNSIPISGALPGSMLTSQSNQQLISLDSNTTSSSGAPK---S 517

  Fly   468 SCSAAIGTLPA------AAPTESAATPLMP--------LEPL-------------------VSKI 499
            :...|..|.||      .:...|:::|:.|        :||:                   |:.:
 Frog   518 NAELAGNTKPAEETVNKESGNASSSSPVAPNSISAQPKIEPMKALDSRFTERSKATSGTAGVAHL 582

  Fly   500 DLGRLDSRLKTQ----------------------PA----SQRRQSLPFDPGQSNELLR---TPR 535
            :...:| |||.|                      ||    |:|:.....|.|:..:..|   .||
 Frog   583 NQTAVD-RLKEQNVTKDSKPREVLESSSDSEEKIPATKQLSKRKGESDADLGEKRKKGRPRKDPR 646

  Fly   536 LE-----EHQSSTCSPSNLNVTATG------------KSEFVKAALDYRLHVS-NGHLKTQHG-M 581
            |.     :.|.::.|...|....|.            ||..|:.:.|..:::. ...:||..| .
 Frog   647 LSVSLTLQSQVASTSEKELTCVTTSSLTLKLPTPTPQKSFTVQLSSDPSMYIEVENEVKTVGGNK 711

  Fly   582 LAKVTA-SDSKEMLWEFYV--------GSPLVNLNLCEKYAMLCSLDGSMRLISMETGCPVFPAI 637
            |:::.. .:.||  ||..:        ||..|....||| .||....||        |..:||.|
 Frog   712 LSQLKCHREGKE--WEAVLTSRILAAAGSNEVVCVACEK-RMLSIFSGS--------GRRLFPPI 765

  Fly   638 SLTS--SAVHCAFSPDNSLVGVLTECGLLRIWDIAKKVVSLAAGCLE--LLNKHGTAAQFSVTNQ 698
            .|.|  |.:.|.    .|.|..||....|.:||:..:.|.:....|:  |.....|.:|..:|.:
 Frog   766 ILPSPISTLQCT----GSYVMALTAAAALSVWDVQNQKVIIKDESLQPLLSGNDMTVSQTLLTKR 826

  Fly   699 GMPLIGFPSGNSYSYSTSLQSWLVLATKDAIMYH--GIRGTLPRDMDQMQQKFPLLSMQASSQNY 761
            |:|::...:|.:|.:|.||.:|.:::.|...:..  ..|..:| ..|.:....||..:|..:.|
 Frog   827 GIPVLNLSNGKAYCFSPSLSTWSLVSDKQDSLTQCADYRNCMP-SQDAIMCSGPLAIIQGRASN- 889

  Fly   762 FSFTGSMELR-----HSESWQQCAKIRFIENQIKLCEALQSLDELQHWHKMLTFQLATHGSEKRM 821
               .|....|     |..  ||...:.::|||:.....|||..|.:||..:....|...|.|:|:
 Frog   890 ---AGRQAARLFTMPHQV--QQETTMAYLENQVAAALMLQSSQEYRHWLLIYARYLVNEGFEQRL 949

  Fly   822 RVFLDDLLS-MPEPGISQF------VPKLELMQCVLDTLKPHSEWNRLHSEYTELL 870
            |....|||. :.....||:      :.|.||::.:|..:..:..:.||.:||.|.|
 Frog   950 REVCQDLLGPVHNSSDSQWESRILGLRKRELLKELLPLIGQNLRFQRLFTEYQEQL 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	222/360 (62%)
		WD40	14..349	CDD:238121	211/337 (63%)
		WD40 repeat	16..68	CDD:293791	34/51 (67%)
		WD40 repeat	74..127	CDD:293791	29/54 (54%)
		WD40 repeat	132..169	CDD:293791	21/36 (58%)
		WD40 repeat	176..211	CDD:293791	20/34 (59%)
		WD40 repeat	223..263	CDD:293791	31/39 (79%)
		WD40 repeat	275..322	CDD:293791	25/47 (53%)
		WD40 repeat	328..350	CDD:293791	8/21 (38%)
		HIRA_B	423..442	CDD:286531	13/18 (72%)
		Hira	629..820	CDD:284895	54/201 (27%)
hira	XP_002931950.2	WD40	7..352	CDD:238121	214/344 (62%)
		WD40 repeat	16..68	CDD:293791	34/51 (67%)
		WD40 repeat	74..129	CDD:293791	29/54 (54%)
		WD40 repeat	134..171	CDD:293791	21/36 (58%)
		WD40 repeat	178..213	CDD:293791	20/34 (59%)
		WD40 repeat	226..265	CDD:293791	31/38 (82%)
		WD40 repeat	273..324	CDD:293791	26/50 (52%)
		WD40 repeat	331..353	CDD:293791	8/21 (38%)
		HIRA_B	448..470	CDD:370503	14/21 (67%)
		Mcl1_mid	<708..>782	CDD:372058	25/88 (28%)
		Hira	758..948	CDD:369430	54/200 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9625
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H48172
Inparanoid	1	1.050	598	1.000	Inparanoid score	I949
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D366817at33208
OrthoFinder	1	1.000	-	-		FOG0003162
OrthoInspector	1	1.000	-	-		oto102422
Panther	1	1.100	-	-	LDO	PTHR13831
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160