DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and aaas

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	XP_002936677.1	Gene:	aaas / 100485071	XenbaseID:	XB-GENE-967146	Length:	519	Species:	Xenopus tropicalis

Alignment Length:	317	Identity:	66/317 - (20%)
Similarity:	103/317 - (32%)	Gaps:	120/317 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KPAWVHHDDKQIFSVDIHKDCTKFATGGQGSDCGRVVIWN---LLPVLSDKAEFDADVPKMLCQM 66
            |.|::||.:      .|.|.|..              .|:   |...|.:.:....:||..||.:
Frog    66 KTAFIHHKE------SIWKRCLN--------------AWHNVGLAGFLEEMSNSKEEVPPWLCHV 110

  Fly    67 DQ------------------HLAC-------------------VNCVRWSQNGQNLASGSDDKLI 94
            .:                  ||..                   :....|..:....|....|..|
Frog   111 ARCSLAVCRSVSSLHGSLFPHLTMKSEDLTAEFSQALDWADSPLRAFAWHPHTNKFALALLDDSI 175

  Fly    95 MIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQ 159
            .|:  :|||..:     ....|...|          ||..:||.|....:.:.:..:.|::|...
Frog   176 RIY--TAGSPTI-----PTLKHRLQK----------DVASMAWKPMCASVLAVACQSCVLVWHVD 223

  Fly   160 AFPHSVAT--------LKGHTG--LVKGVSWDPLGRFLASQSD-DRSIKIWNTMNWSLSHTITEP 213
              |.|::|        :..|.|  .|..|.|.|.|..|.|.|. |.::.:|:.           |
Frog   224 --PTSLSTRPSSGCAQVLSHPGHSPVTSVCWSPKGGVLLSASPVDTAMLVWDV-----------P 275

  Fly   214 FEEC--------GGTTHILRLSWSPDGQYLVSAHAMNGGGPTA--QIIEREGWKCDK 260
            .|.|        ||.|.   |||||||..:::|      .|:.  ::.|.:.|.|::
Frog   276 TESCIPLQRVGGGGVTF---LSWSPDGSKVLAA------TPSCVFRVWETQKWTCER 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	62/310 (20%)
		WD40	14..349	CDD:238121	62/308 (20%)
		WD40 repeat	16..68	CDD:293791	10/54 (19%)
		WD40 repeat	74..127	CDD:293791	10/52 (19%)
		WD40 repeat	132..169	CDD:293791	9/44 (20%)
		WD40 repeat	176..211	CDD:293791	9/35 (26%)
		WD40 repeat	223..263	CDD:293791	12/40 (30%)
		WD40 repeat	275..322	CDD:293791
		WD40 repeat	328..350	CDD:293791
		HIRA_B	423..442	CDD:286531
		Hira	629..820	CDD:284895
aaas	XP_002936677.1	WD40	152..413	CDD:392136	50/211 (24%)
		WD40 repeat	155..190	CDD:293791	8/41 (20%)
		WD40 repeat	196..240	CDD:293791	9/45 (20%)
		WD40 repeat	248..286	CDD:293791	12/48 (25%)
		WD40 repeat	290..328	CDD:293791	13/43 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910