DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and wdr47

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	XP_031756900.1	Gene:	wdr47 / 100127667	XenbaseID:	XB-GENE-5787016	Length:	919	Species:	Xenopus tropicalis

Alignment Length:	355	Identity:	80/355 - (22%)
Similarity:	139/355 - (39%)	Gaps:	62/355 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DDKQIFSVDIHKDCTKFATGGQGSDCGRVVIWNLLPVLSDKAEFDADV--PKMLCQMDQHLACVN 74
            |.:.:.:|..|...:.:|. |..|...||..:   |.:.|.:..:...  |....:...|...:.
Frog   605 DTQAVRAVAFHPSGSLYAV-GSNSKTLRVCAY---PDVIDTSNSNCPTQPPVRFKRNKHHKGSIY 665

  Fly    75 CVRWSQNGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAW-- 137
            ||.||..||.||:||:||.:.:...||.:....|..            .....|||.:.|||:
Frog   666 CVAWSPCGQLLATGSNDKYVKVLPFSAETCNATGPD------------LEFSMHDGTIRDLAFME 718

  Fly   138 ---SPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGV-SWDPLGRFLASQSDDRSIKI 198
               |...:.:::.:.|..:...|.|. ...:..|.||||.:..: :|.  |..:||.|.|::::.
Frog   719 GPESGGAILISAGAGDCNIYTTDCQR-GQGLHALSGHTGHILALYTWS--GWMIASGSQDKTVRF 780

  Fly   199 WNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKCDKDFV 263
            |:....|....|...|...|..  :..::..|.|:.|.:...    ..:..:.:..|.:..:.:.
Frog   781 WDLRVPSCVRVIGTTFHGTGSA--VASVAVDPSGRLLATGQE----DSSCMLYDIRGGRMVQSYH 839

  Fly   264 GHRKAVTCVRFHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLSVWMTALQ----RPMVVI---- 320
            .|...|..|||            ||.  ..|  |..||.|  :.|.:|.||    :|:.:|
Frog   840 PHSSDVRSVRF------------SPG--AHY--LLTGSYD--MKVKVTDLQGDLTKPLPIIEVGE 886

  Fly   321 HELFNASILDLTWGPQECLLMACSVDGSIA 350
            |:   ..::...|..|:...::.|.|.:::
Frog   887 HK---DKVIQCRWHTQDLSFLSSSADRTVS 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	80/355 (23%)
		WD40	14..349	CDD:238121	79/350 (23%)
		WD40 repeat	16..68	CDD:293791	10/53 (19%)
		WD40 repeat	74..127	CDD:293791	15/52 (29%)
		WD40 repeat	132..169	CDD:293791	7/41 (17%)
		WD40 repeat	176..211	CDD:293791	8/35 (23%)
		WD40 repeat	223..263	CDD:293791	4/39 (10%)
		WD40 repeat	275..322	CDD:293791	13/54 (24%)
		WD40 repeat	328..350	CDD:293791	4/21 (19%)
		HIRA_B	423..442	CDD:286531
		Hira	629..820	CDD:284895
wdr47	XP_031756900.1	LisH_TPL	13..40	CDD:375350
		CTLH	47..102	CDD:128914
		Myosin_tail_1	<422..>500	CDD:396244
		WD40	606..915	CDD:238121	79/354 (22%)
		WD40 repeat	611..659	CDD:293791	10/51 (20%)
		WD40 repeat	665..706	CDD:293791	15/52 (29%)
		WD40 repeat	711..752	CDD:293791	7/41 (17%)
		WD40 repeat	762..795	CDD:293791	9/34 (26%)
		WD40 repeat	803..837	CDD:293791	4/37 (11%)
		WD40 repeat	845..885	CDD:293791	17/57 (30%)
		WD40 repeat	891..915	CDD:293791	4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910