Protein Alignment CHES-1-like and Foxo1

DIOPT Version :10

• Sequence 1: NP_511071.3
• Gene: CHES-1-like / 31678
• FlyBaseID: FBgn0029504
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001178775.1
• Gene: Foxo1 / 84482
• RGDID: 620283
• Length: 649
• Species: Rattus norvegicus
• Alignment Length: 719
• Identity: 149/719 - (20%)
• Similarity: 237/719 - (32%)
• Gaps: 265/719 - (36%)

  Fly   460 PVPKTSSFSTVFEAVNYATSAASNSSSSSNSTPNSQAILHGQESPAVVTTTTLISAGTLPPGYSF 524
            |:|:..     |...|..||:.:.|.|:: :.|::.|.|   .|.:.|:|..:.:...|.....|
  Rat    26 PLPRPE-----FNQSNSTTSSPAPSGSTA-ANPDATASL---ASASAVSTDFMSNLSLLEESEDF 81

  Fly   525 VNQVASTPHVLSTPA--------------------HVASPETPPGAALLPGTYYATSTTSAGTTT 569
                |..|..::..|                    |.|.|:.||...|
  Rat    82 ----ARAPGCVAVAAAAAASRGLCGDFQGPEAGCVHSAPPQPPPTGPL----------------- 125

  Fly   570 TTLQARSLQLSVSPPPPNMTPTSQVHNGSLGGGGGGGGGSGGGGGGGGANLRSPNSYASYDNEDS 634
                        |.||| :.|.:.   |.|.|
  Rat   126 ------------SQPPP-VPPAAA---GPLAG--------------------------------- 141

  Fly   635 LKEFDLVVSSRLHTSTPQYSVSKNGANGYGNGNSNVNGSGAGSNTPQKQKHPNNVPYDPLVHTNN 699
                           .|: ..|.:..|.:||
  Rat   142 ---------------QPR-KTSSSRRNAWGN---------------------------------- 156

  Fly   700 KPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFK-----TAPNGWKNSVRHNLSLNKSFV 759
               .|::.||..|||.|.||.|.:.:||.|:|:..||||     .:..|||||:||||||:..|:
  Rat   157 ---LSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFI 218

  Fly   760 KVEKAPNMGKGSLWRVEPQQRQNLIQALNRSPFFPNSAVDKISPSLKSPSGGSAYD--SLDGGGS 822
            :|:. ...||.|.|.:.|:..::     .:||....:::|..|...|| .|.:|..  ||..|..
  Rat   219 RVQN-EGTGKSSWWMLNPEGGKS-----GKSPRRRAASMDNNSKFAKS-RGRAAKKKASLQSGQE 276

  Fly   823 GSVSSAQPVAGGAGVPAAAAVALSTPTKSNGLALANGASQATNAARPHSPNGGGSGSHARFDPYL 887
            |                        |..|.|...:..         |.||     |||:..|
  Rat   277 G------------------------PGDSPGSQFSKW---------PASP-----GSHSNDD--- 300

  Fly   888 FPNLSKAFR---NIREDTVG---QPML--QDALDDELSGDYHNNNNNNSGSKYNYMGANGSGGAG 944
            |.|.| .||   :....|:.   .|::  ||.|.|   ||.|:.....|.:|.
  Rat   301 FDNWS-TFRPRTSSNASTISGRLSPIMTEQDDLGD---GDVHSLVYPPSAAKM------------ 349

  Fly   945 SGGVGSNANGASDGINFARLARDCGADSIDDVHAAAAMLYLKHGPKIYSEPFQNGSGPVITSSPS 1009
                      ||...:.:.::.....:::.|      .|.|...|...:...|:..|.::..:|.
  Rat   350 ----------ASTLPSLSEISNPENMENLLD------NLNLLSSPTSLTVSTQSSPGSMMQQTPC 398

  Fly  1010 EDHTYSAGGNS-NADSGSSTPLTNGNALASVA-----QAVAQGQNNQGGAGSDSNCA----SSDA 1064
              ::::....| |:.|.:....|.|.:..|..     |.:...:::.||. :..|||    ....
  Rat   399 --YSFAPPNTSLNSPSPNYAKYTYGQSSMSPVPQMPMQTLQDSKSSYGGL-NQYNCAPGLLKELL 460

  Fly  1065 AYDSSEENHNITPEEMADRQRHRDGVDALLSLSGSSIVEC-GSVATTHYHSNGSSGSSHGSP-HK 1127
            ..||...|..::|.:....|.:...:...:.:..:|::.. ||.|.   |:...:.|||..| |.
  Rat   461 TSDSPPHNDIMSPVDPGVAQPNSRVLGQNVLMGPNSVMPAYGSQAP---HNKMMNPSSHTHPGHA 522

  Fly  1128 RASS 1131
            :.:|
  Rat   523 QQTS 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_511071.3	FH_FOXN2-like	700..775	CDD:410805	35/79 (44%)
Foxo1	NP_001178775.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62		12/44 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..151		16/120 (13%)
		FH_FOXO1	145..243	CDD:410834	40/140 (29%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	205..212		5/6 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	228..339		38/161 (24%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	228..231		1/2 (50%)
		Nuclear localization signal. /evidence=ECO:0000250	245..247		0/1 (0%)
		Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0	277..557		64/329 (19%)
		Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0	357..453		18/104 (17%)
		FOXO_KIX_bdg	417..498	CDD:465228	15/81 (19%)
		Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0	456..460		0/3 (0%)
		FOXO-TAD	591..627	CDD:435506