DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHES-1-like and Foxk2

DIOPT Version :9

Sequence 1:	NP_001259311.1	Gene:	CHES-1-like / 31678	FlyBaseID:	FBgn0029504	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	XP_011247520.1	Gene:	Foxk2 / 68837	MGIID:	1916087	Length:	690	Species:	Mus musculus

Alignment Length:	725	Identity:	159/725 - (21%)
Similarity:	246/725 - (33%)	Gaps:	249/725 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 GSSPAGGGTIYKAASQALS------SPTTSSSSSSNTTTHHPHKKYLREKMHVQMDHSSHVASTV 422
            |.||.||..:.:...:...      |.|...:||..:             :.|.|.|||.::...
Mouse    22 GGSPPGGWAVARLEGREFEYLMKKRSVTIGRNSSQGS-------------VDVSMGHSSFISRRH 73

  Fly   423 TVVSSPASSNNSSISSSNTGSVSGSGSSTAAVN--------GGN---SPVPKTSSF-STVFEAVN 475
            ..:.:|                .|.|.|.||..        ||:   ..:.|...| ..||:
Mouse    74 LEIFTP----------------PGGGHSAAAPEPAQPRPDAGGDFYLRCLGKNGVFVDGVFQ--- 119

  Fly   476 YATSAASNSSSSSNSTPNSQAILHGQESPAVVTTTTLISAGTLPPGYSFVNQVASTPHVLSTPAH 540
                        ....|..|.       |.||   ::.|.|.  ||...|:.....|.:......
Mouse   120 ------------RRGAPPLQL-------PRVV---SICSPGC--PGNCCVDHRPCWPEIYRNLPA 160

  Fly   541 VASPETPPGAALLPGTYYATSTTSAGTTTTTLQARSLQLSVSPPPPNMTPTSQVHNGSLGGGGGG 605
            .|.||..|....     :...:|:...|.|.|.:...:...:|..| :.|. |.|...|
Mouse   161 SAFPEYWPSRCT-----FRFPSTNIKITFTALSSEKREKQEAPESP-VKPV-QPHISPL------ 212

  Fly   606 GGGSGGGGGGGGANLRSPNSYASYDNEDSLKEFDLVVSSRLHTSTPQYSVSKN--------GANG 662
                         .:..|::.|.             :.|.|.:.|...|.:.:        |::|
Mouse   213 -------------TINIPDTMAH-------------LISPLPSPTGTISAANSCPSSPRGAGSSG 251

  Fly   663 YGNGNSNVNGSG--AGSNTPQKQKHPN--NVPYDPLVHTNNKPPYSFSSLIFMAIEGSNEKALPV 723
            |..|....:...  |.::.|:.:|..:  :.|.|     ::|||||::.||..||..:.:|.|.:
Mouse   252 YKVGRVMPSDLSLMADNSQPENEKEASGGDSPKD-----DSKPPYSYAQLIVQAITMAPDKQLTL 311

  Fly   724 KEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKVEKA-PNMGKGSLWRVEPQQRQNLI-QA 786
            ..||..|.:::||::||..||:||:|||||||:.|:||.:: ...||||.||::|.....|: ||
Mouse   312 NGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASESKLVEQA 376

  Fly   787 LN----------RSPFFPNSAVDKISPSLKSP----------SGGSAYDSLDGGGS--------- 822
            ..          |:|..|.|:  :.:|:  ||          ||....:||...||
Mouse   377 FRKRRPRGVPCFRTPLGPLSS--RSAPA--SPNHAGVLSAHSSGAQTPESLSREGSPAPLEPEPG 437

  Fly   823 -------------------GSVSSAQPV--AGGAGVPAA-------AAVALSTPTKS-------- 851
                               ||..|:|||  .....:|.|       .|..::|||..
Mouse   438 ASQPKLAVIQEARFAQSAPGSPLSSQPVLITVQRQLPPAIKPVTYTVATPVTTPTSQPPVVQTVH 502

  Fly   852 -------------NGLALAN-----GASQATNAA--RPHSPNGGGSGSHARFD------PYLFPN 890
                         .|||.||     |.:..|.||  .|.:|....:|.|....      |.:.|.
Mouse   503 VVHQIPAVSVTSVAGLAPANTYTVAGQAVVTQAAVLAPPNPEPQENGDHREVRVKVEPVPAISPA 567

  Fly   891 LSKAFRNIREDTVGQPMLQDALDDEL--------------SGDY--------HNNNNNNSGSKYN 933
            ...|...|.:.:.|.|:....:..:.              :|.:        |:..||.:.|..:
Mouse   568 TLGAASRIIQTSQGTPVQTVTIVQQAPLGQHQLPIKTVTQNGAHVVPMPTAVHSQVNNAAASPLH 632

  Fly   934 YMGANGSGGA 943
            .:..:.|..|
Mouse   633 MLATHASASA 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_001259311.1	Forkhead	700..785	CDD:278670	40/86 (47%)
Foxk2	XP_011247520.1	FHA	41..>124	CDD:238017	21/126 (17%)
		COG5025	<175..>381	CDD:227358	67/244 (27%)
		Forkhead	287..373	CDD:365978	39/85 (46%)
		PHA03247	<380..683	CDD:223021	51/267 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45881
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010