DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CHES-1-like and FOXD4L5

DIOPT Version :9

Sequence 1:	NP_001259311.1	Gene:	CHES-1-like / 31678	FlyBaseID:	FBgn0029504	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001119806.1	Gene:	FOXD4L5 / 653427	HGNCID:	18522	Length:	416	Species:	Homo sapiens

Alignment Length:	263	Identity:	74/263 - (28%)
Similarity:	105/263 - (39%)	Gaps:	46/263 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   664 GNGNSNVNGSGAGSNTPQKQKHPNNVPYDPLVHTNNKPPYSFSSLIFMAIEGSNEKALPVKEIYA 728
            |.|.|:.:..|.....|.:....:.....|.     |||||:.:||.|||..:..|.|.:..|.|
Human    77 GGGPSDPSEFGTKFRAPPRSAAASEDARQPA-----KPPYSYIALITMAILQNPHKRLTLSGICA 136

  Fly   729 WIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKVEKAP-NMGKGSLWRVEPQ-------------- 778
            :|...|||::.....|:||:|||||||..|||:.:.| :.|||:.|.::|.
Human   137 FISGRFPYYRRKFPAWQNSIRHNLSLNDCFVKIPREPGHPGKGNYWSLDPASQDMFDNGSFLRRR 201

  Fly   779 ---QRQNLIQALNRSPFFPNSAVDKISPSLKSPSGGSAYDSLDGGGSGSVSSAQPVAGG--AGVP 838
               :|..|....:....||..|.   ..:|.:|..|...        |:.:..|||.|.  ...|
Human   202 KRFKRHQLTPGAHLPHPFPLPAA---HAALHNPHPGPLL--------GAPAPPQPVPGAYPNTAP 255

  Fly   839 AAAAVALSTPTKSNGLALANGASQATNAARPHSPNGGGSGSHARF---DPYLFPNL---SKAFRN 897
            .....||..|.....|.|    |....|..|....|....:.|.|   .|:|..:|   ::.:|.
Human   256 GRCPYALLHPHPLRYLLL----SAPVYAGAPKKAEGADLATPAPFPCCSPHLVLSLGRRARVWRR 316

  Fly   898 IRE 900
            .||
Human   317 HRE 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_001259311.1	Forkhead	700..785	CDD:278670	39/102 (38%)
FOXD4L5	NP_001119806.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	70..105		5/27 (19%)
		Forkhead	108..194	CDD:278670	37/85 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910