DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CHES-1-like and Foxm1

DIOPT Version :9

Sequence 1:	NP_001259311.1	Gene:	CHES-1-like / 31678	FlyBaseID:	FBgn0029504	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_113821.2	Gene:	Foxm1 / 58921	RGDID:	61807	Length:	771	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	97/417 - (23%)
Similarity:	150/417 - (35%)	Gaps:	111/417 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   428 PASSNNSSISSSNTGSVSGSGSSTAAVNGGNSPVPKTSS--FSTVFEAVNYATSAASNSSSSSNS 490
            |....|:...:|...:....|.........:..|.::||  |....:.:|:.|
  Rat    17 PLPIQNAPSETSEEEAKRSPGQQEPTQAQASQDVAESSSCKFPAGIKIINHPT------------ 69

  Fly   491 TPNSQ--AILHGQESPAVVTTTTL---ISAGTLPPGYSFVNQVASTPHVLSTPAHVASPETPPGA 550
            .||:|  ||.:..:..:::|..|.   .|..:.|..:..::...::.|             ||.
  Rat    70 MPNTQVVAIPNNADIQSIITALTAKGKESGSSGPNKFILISSGGASSH-------------PPD- 120

  Fly   551 ALLPGTYYATSTTSAGT--TTTTLQARSLQLSVS-PPPPNMTPTSQVHNGSLGGGGGGGGGSGGG 612
               |.:...|||.|..|  .|.||..:.....|. |.||...|..:  ..|.||...|
  Rat   121 ---PQSQAQTSTDSKRTELITETLGPKPGAKGVPVPKPPGALPRQR--QESCGGEAAG------- 173

  Fly   613 GGGGGANLRSPNSYASYDNEDSLKEFDLVVSSRLHTSTPQYSVSKNGANGYG----------NGN 667
                          .:.||  ||.....              :.|..::|.|          ..|
  Rat   174 --------------CTLDN--SLTNIQW--------------LGKMSSDGLGRCSIKQELEEKEN 208

  Fly   668 SNVNGSGAGSNTPQKQKHPNNVPYDPLVHTNNKPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQ 732
            .::..:......|.:.    :|.:...|  :.:||||:.::|..||..:..|.:.:|:||.||..
  Rat   209 CHLEQNRVKVEAPSRA----SVSWQDSV--SERPPYSYMAMIQFAINSTERKRMTLKDIYTWIED 267

  Fly   733 HFPYFK-TAPNGWK------------NSVRHNLSLNKSFVKVEKAPNMGKGSLWRVEPQQRQNLI 784
            |||||| .|..|||            ||:||||||:..||: |.:.| ||.|.|.:.|...:.|.
  Rat   268 HFPYFKHIAKPGWKCWHQAYHKLGPQNSIRHNLSLHDMFVR-ETSAN-GKVSFWTIHPSANRYLT 330

  Fly   785 QALNRSPFFPNS--AVDKISPSLKSPS 809
            ......|..|.|  :.:.:....|.|:
  Rat   331 LDQVFKPLEPGSPQSPEHLESQQKRPN 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_001259311.1	Forkhead	700..785	CDD:278670	41/97 (42%)
Foxm1	NP_113821.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		5/36 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..165		19/89 (21%)
		FH	235..322	CDD:238016	39/88 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..361		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..568
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..655
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910