DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CHES-1-like and foxh1

DIOPT Version :9

Sequence 1:NP_001259311.1 Gene:CHES-1-like / 31678 FlyBaseID:FBgn0029504 Length:1268 Species:Drosophila melanogaster
Sequence 2:NP_571577.1 Gene:foxh1 / 57930 ZFINID:ZDB-GENE-000616-15 Length:472 Species:Danio rerio


Alignment Length:478 Identity:113/478 - (23%)
Similarity:169/478 - (35%) Gaps:140/478 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   640 LVVSSRLHTSTPQYSVSKNGANGYGNGNSNV-NGSGAGSNTPQKQKHPNNVPYDPLVHTNNKPPY 703
            |.:..||..||.....|...|.....|...: :|:.:|......|::|             ||||
Zfish    49 LELGGRLDKSTGMAQDSCYRAKATNQGPWELQDGNSSGGKKKNYQRYP-------------KPPY 100

  Fly   704 SFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKVEKAPN-- 766
            |:.::|.|.|:.|.||.|.:.||...|...||:||....||::|||||||....||||.|.|.  
Zfish   101 SYLAMIAMVIQNSPEKKLTLSEILKEISTLFPFFKGNYKGWRDSVRHNLSSYDCFVKVLKDPGKP 165

  Fly   767 MGKGSLWRVEPQ-------QRQN--------LIQALNRSPFF--------------PNSAVDKIS 802
            .|||:.|.||..       :|||        .|.|.:.:|:.              |.|::..: 
Zfish   166 QGKGNFWTVEVNRIPLELLKRQNTAVSRQDETIFAQDLAPYIFQGYSQPNKSKPLPPESSLPPV- 229

  Fly   803 PSLKSPSGGS-----------AYDSLDGGGSGSVSSAQPV-AGGAGVPAAAAVALSTPTKSNGLA 855
            |:.:||....           |.|||       :.|.:|. :.|.|:....:..:..|..     
Zfish   230 PTRQSPPPSEDPYRPKLDSTFAIDSL-------LHSLRPASSAGEGLRERESWGVGPPPH----- 282

  Fly   856 LANGASQATNAARPHSPNGGGSGSHARFDPYLFPNLSKAFRNIREDTVG----------QPMLQD 910
                 :::|...||.:.:..||.|.:...|      :..|.:  ||..|          :.:..|
Zfish   283 -----TRSTTPPRPCNASYNGSSSASSVSP------ASDFSD--EDWRGVTVVGKRSGDRGITSD 334

  Fly   911 ALDDELSGDYHNNNNNN--------SGSKYN--------YMGANGSGGAGSGGVGSNANGASDGI 959
            |..|.......::...|        |.:||.        .|..||:.....||:.....|.:   
Zfish   335 AYSDSCPPPNKSSKRGNTPPWELPTSYAKYTPPNAVAPPSMRFNGNPFMPLGGIPFYGYGGA--- 396

  Fly   960 NFARLARDCGADSIDDVHAAAAML-------YLKHGP-KIYSEPFQNGSGPVITSSPSEDHTYSA 1016
                             |...:.|       .|..|| .|.:.|.......::.|.|.....:.|
Zfish   397 -----------------HVTTSHLIGHPYWPILPSGPVSIQAPPLLMDLDSMLQSVPPNKSVFDA 444

  Fly  1017 GGNSNA---DSGSSTPLTNGNAL 1036
            .|::|.   .|.:...|.||.:|
Zfish   445 LGSNNQTVHPSPNQYALQNGPSL 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHES-1-likeNP_001259311.1 Forkhead 700..785 CDD:278670 43/101 (43%)
foxh1NP_571577.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..56 2/6 (33%)
FH 97..174 CDD:238016 38/76 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..246 5/35 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..360 19/116 (16%)
SMAD-interaction domain (SID) 339..465 25/145 (17%)
Fast/FoxH1 motif 1 (FM1) 357..361 0/3 (0%)
Fast/FoxH1 motif 2 (FM2) 367..373 0/5 (0%)
SMAD interaction motif (SIM) 428..448 4/19 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG2294
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270467at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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