DRSC/TRiP Functional Genomics Resources

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Protein Alignment CHES-1-like and Foxo1

DIOPT Version :10

Sequence 1:NP_511071.3 Gene:CHES-1-like / 31678 FlyBaseID:FBgn0029504 Length:1268 Species:Drosophila melanogaster
Sequence 2:NP_062713.2 Gene:Foxo1 / 56458 MGIID:1890077 Length:652 Species:Mus musculus


Alignment Length:799 Identity:162/799 - (20%)
Similarity:265/799 - (33%) Gaps:283/799 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   460 PVPKTSSFSTVFEAVNYATSAASNSSSSSNSTPNSQAILHGQESPAVVTTTTLISAGTLPPGYSF 524
            |:|:..     |...|..||:.:.|..:: :.|::.|.|   .|.:.|:|..:.:...|.....|
Mouse    26 PLPRPE-----FNQSNSTTSSPAPSGGAA-ANPDAAASL---ASASAVSTDFMSNLSLLEESEDF 81

  Fly   525 VNQVASTPHVLSTPA--------------------HVASPETPPGAALLPGTYYATSTTSAGTTT 569
                |..|..::..|                    |.|.|:.||...|                 
Mouse    82 ----ARAPGCVAVAAAAAASRGLCGDFQGPEAGCVHPAPPQPPPTGPL----------------- 125

  Fly   570 TTLQARSLQLSVSPPPPNMTPTSQVHNGSLGGGGGGGGGSGGGGGGGGANLRSPNSYASYDNEDS 634
                        |.||| :.|::....|.|.|                                 
Mouse   126 ------------SQPPP-VPPSAAAAAGPLAG--------------------------------- 144

  Fly   635 LKEFDLVVSSRLHTSTPQYSVSKNGANGYGNGNSNVNGSGAGSNTPQKQKHPNNVPYDPLVHTNN 699
                           .|: ..|.:..|.:||                                  
Mouse   145 ---------------QPR-KTSSSRRNAWGN---------------------------------- 159

  Fly   700 KPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFK-----TAPNGWKNSVRHNLSLNKSFV 759
               .|::.||..|||.|.||.|.:.:||.|:|:..||||     .:..|||||:||||||:..|:
Mouse   160 ---LSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFI 221

  Fly   760 KVEKAPNMGKGSLWRVEPQQRQNLIQALNRSPFFPNSAVDKISPSLKSPSGGSAYD--SLDGGGS 822
            :|:. ...||.|.|.:.|:..::     .:||....:::|..|...|| .|.:|..  ||..|..
Mouse   222 RVQN-EGTGKSSWWMLNPEGGKS-----GKSPRRRAASMDNNSKFAKS-RGRAAKKKASLQSGQE 279

  Fly   823 GSVSSAQPVAGGAGVPAAAAVALSTPTKSNGLALANGASQATNAARPHSPNGGGSGSHARFDPYL 887
            |                        |..|.|...:..         |.||     |||:..|   
Mouse   280 G------------------------PGDSPGSQFSKW---------PASP-----GSHSNDD--- 303

  Fly   888 FPNLSKAFR---NIREDTVG---QPML--QDALDDELSGDYHNNNNNNSGSKYNYMGANGSGGAG 944
            |.|.| .||   :....|:.   .|::  ||.|.|   ||.|:.....|.:|.            
Mouse   304 FDNWS-TFRPRTSSNASTISGRLSPIMTEQDDLGD---GDVHSLVYPPSAAKM------------ 352

  Fly   945 SGGVGSNANGASDGINFARLARDCGADSIDDVHAAAAMLYLKHGPKIYSEPFQNGSGPVITSSPS 1009
                      ||...:.:.::.....:::.|      .|.|...|...:...|:..|.::..:|.
Mouse   353 ----------ASTLPSLSEISNPENMENLLD------NLNLLSSPTSLTVSTQSSPGSMMQQTPC 401

  Fly  1010 EDHTYSAGGNS-NADSGSSTPLTNGNALAS-----VAQAVAQGQNNQGGAGSDSNCA----SSDA 1064
              ::::....| |:.|.:.:..|.|.:..|     ..|.:...:::.||. :..|||    ....
Mouse   402 --YSFAPPNTSLNSPSPNYSKYTYGQSSMSPLPQMPMQTLQDSKSSYGGL-NQYNCAPGLLKELL 463

  Fly  1065 AYDSSEENHNITPEEMADRQRHRDGVDALLSLSGSSIVEC-GSVATTHYHSNGSSGSSHGSPHKR 1128
            ..||...|..::|.:....|.:...:...:.:..:|::.. ||.|:.:...|.||.:..|...:.
Mouse   464 TSDSPPHNDIMSPVDPGVAQPNSRVLGQNVMMGPNSVMPAYGSQASHNKMMNPSSHTHPGHAQQT 528

  Fly  1129 ASSHSLEEEHL--------QQHREQQLQQQQQQQQHHHQQ---FGSSQAVYT-NGSGSKMALLSS 1181
            ||.:.....|:        ..:|...::...|....|..|   .||..:|.: ||.| :|.:|  
Mouse   529 ASVNGRTLPHVVNTMPHTSAMNRLTPVKTPLQVPLSHPMQMSALGSYSSVSSCNGYG-RMGVL-- 590

  Fly  1182 AAANVALAQQQQQQIHQDM 1200
                      .|:::..|:
Mouse   591 ----------HQEKLPSDL 599

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHES-1-likeNP_511071.3 FH_FOXN2-like 700..775 CDD:410805 35/79 (44%)
Foxo1NP_062713.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..62 11/44 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..154 16/120 (13%)
FH_FOXO1 148..246 CDD:410834 40/140 (29%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 208..215 5/6 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..342 38/161 (24%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 231..234 1/2 (50%)
Nuclear localization signal. /evidence=ECO:0000250 248..250 0/1 (0%)
Sufficient for interaction with NLK. /evidence=ECO:0000269|PubMed:20061393 280..562 66/357 (18%)
Required for interaction with RUNX2. /evidence=ECO:0000269|PubMed:21471200 360..456 18/104 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..410 3/28 (11%)
FOXO_KIX_bdg 420..501 CDD:465228 15/81 (19%)
Required for interaction with SIRT1. /evidence=ECO:0000269|PubMed:15220471 459..463 0/3 (0%)
FOXO-TAD 594..630 CDD:435506 1/6 (17%)

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