DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CHES-1-like and foxh1

DIOPT Version :9

Sequence 1:	NP_001259311.1	Gene:	CHES-1-like / 31678	FlyBaseID:	FBgn0029504	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001017084.1	Gene:	foxh1 / 549838	XenbaseID:	XB-GENE-1194372	Length:	515	Species:	Xenopus tropicalis

Alignment Length:	534	Identity:	112/534 - (20%)
Similarity:	166/534 - (31%)	Gaps:	217/534 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   547 PPGAALLPGTYYATSTTSAGTTTTTLQARSLQLSVSPPPPNMTPTSQVHNGSLGGGGGGGGGSGG 611
            ||..|||...|......:.|        .|.:....|.||            |...||......|
Frog    22 PPSLALLSSIYQEQVPAAPG--------HSYEQCAQPWPP------------LYREGGTWSPDRG 66

  Fly   612 GGGGGGANLRSPNSYASYDNEDSLKEFDLVVSSRLHTSTPQYSVSKNGANGYGNGNSNVNGSGAG 676
            ...|.....:..:...:...:|||                                      |..
Frog    67 SMHGLSPGTQEGSCTQAEGTKDSL--------------------------------------GGD 93

  Fly   677 SNTPQKQKHPNNVPYDPLVHTNNKPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTAP 741
            ....:|.|..|       .|...|||||:.::|.:.|:.|.||.|.:.:|...:...||:||...
Frog    94 ETLSRKSKKKN-------YHRYAKPPYSYLAMIALVIQNSPEKRLKLSQILKEVSTLFPFFKGDY 151

  Fly   742 NGWKNSVRHNLSLNKSFVKVEKAPN--MGKGSLWRVEPQQRQNLIQALNRSPF----FPNSAVDK 800
            .|||:|:|||||.|..|.||.|.|.  ..||:.|.|:          ::|.|.    ..|:|:.:
Frog   152 MGWKDSIRHNLSSNDCFKKVLKDPGKPQAKGNFWTVD----------VSRIPLDAMKLQNTALTR 206

  Fly   801 ISPSLKSPSGGSAYDSLDGGGSGSVSSAQPVAGGAGVPAAAAVALSTPTKSNGLALA-----NGA 860
                     |||.|...|                    .|..:..:...:.|.:..|     :.|
Frog   207 ---------GGSDYFVQD--------------------LAPYILHNYKYEHNVVVYAPHHMPSHA 242

  Fly   861 SQATNAARPHSPNGGGSGSHARFDPYLFPNLSKAFRNIREDTVGQPMLQDALDDELSGDYHNNNN 925
            |....|..||..|.||             .|:.:|           |:...|:|....|..:...
Frog   243 SSLPLAEDPHQTNTGG-------------KLNTSF-----------MIDSLLNDLQDVDLPDVPR 283

  Fly   926 NNSGSKYNYMGANGSGGAGSGGVGSNANGASDGINFARLARDCGADSIDDVHAAAAMLYLKHGPK 990
            |                                |...|::   .|.:|:::.::|.:||    |:
Frog   284 N--------------------------------IESQRIS---PAVAINNMWSSAPLLY----PQ 309

  Fly   991 IYSEPFQNGSGPVITSSPSEDHTYSAGGNS----------------------------------N 1021
              |:|.:||.||..::|.|   |||:..:|                                  .
Frog   310 --SKPTRNGRGPGFSASHS---TYSSSSSSISTISPVGFQETQERSEDLLGRQTQRLGFPTKRPR 369

  Fly  1022 ADSGSSTPLTNGNA 1035
            .|.|.|||.::.:|
Frog   370 EDDGCSTPSSDTDA 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_001259311.1	Forkhead	700..785	CDD:278670	35/86 (41%)
foxh1	NP_001017084.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..103		10/85 (12%)
		FH	110..188	CDD:238016	34/77 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..399		20/86 (23%)
		SMAD-interaction domain (SID)	377..503		2/7 (29%)
		Fast/FoxH1 motif 1 (FM1). /evidence=ECO:0000255	402..406
		Fast/FoxH1 motif 2 (FM2). /evidence=ECO:0000255	412..418
		SMAD-interaction motif (SIM)	467..488
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920