DRSC/TRiP Functional Genomics Resources

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Protein Alignment CHES-1-like and FOXK2

DIOPT Version :10

Sequence 1:NP_511071.3 Gene:CHES-1-like / 31678 FlyBaseID:FBgn0029504 Length:1268 Species:Drosophila melanogaster
Sequence 2:NP_004505.2 Gene:FOXK2 / 3607 HGNCID:6036 Length:660 Species:Homo sapiens


Alignment Length:560 Identity:129/560 - (23%)
Similarity:192/560 - (34%) Gaps:192/560 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   364 GSSPAGGGTIYKAASQALS------SPTTSSSSSSNTTTHHPHKKYLREKMHVQMDHSSHVAST- 421
            |.||.||..:.:...:...      |.|...:||..:             :.|.|.|||.::.. 
Human    28 GGSPPGGWAVARLEGREFEYLMKKRSVTIGRNSSQGS-------------VDVSMGHSSFISRRH 79

  Fly   422 VTVVSSPASSNNSSIS-----SSNTGSVSGS------GSSTAAVNG-----GNSP--VPKTSSFS 468
            :.:.:.|....:...:     :.......|.      |.:...|:|     |..|  :|:..:|.
Human    80 LEIFTPPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNGVFVDGVFQRRGAPPLQLPRVCTFR 144

  Fly   469 TVFEAVNYATSAASNSSSSSNSTPNSQAILHGQESPAVVTTTTLISAGTLPPGYSFVNQVASTPH 533
              |.:.|...:..:.||........|       ||| |......||..|:              :
Human   145 --FPSTNIKITFTALSSEKREKQEAS-------ESP-VKAVQPHISPLTI--------------N 185

  Fly   534 VLSTPAHVASPETPPGAALLPGTYYATSTTSAGTTTTTLQARSLQLSVSPPPPNMTPTSQVHNGS 598
            :..|.||:.||...|           |.|.||.                    |..|:|.     
Human   186 IPDTMAHLISPLPSP-----------TGTISAA--------------------NSCPSSP----- 214

  Fly   599 LGGGGGGGGGSGGGGGGGGANLRSPNSYASYDNEDSLKEFDLVVSSRLHTSTPQYSVSKNGANGY 663
              .|.|..|...|.......||.:.||....:.|.|                             
Human   215 --RGAGSSGYKVGRVMPSDLNLMADNSQPENEKEAS----------------------------- 248

  Fly   664 GNGNSNVNGSGAGSNTPQKQKHPNNVPYDPLVHTNNKPPYSFSSLIFMAIEGSNEKALPVKEIYA 728
                        |.::|:               .::|||||::.||..||..:.:|.|.:..||.
Human   249 ------------GGDSPK---------------DDSKPPYSYAQLIVQAITMAPDKQLTLNGIYT 286

  Fly   729 WIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKVEKA-PNMGKGSLWRVEPQQRQNLI-QALN--- 788
            .|.:::||::||..||:||:|||||||:.|:||.:: ...||||.||::|.....|| ||..   
Human   287 HITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASESKLIEQAFRKRR 351

  Fly   789 -------RSPFFPNSAVDKISPSLKSP----------SGGSAYDSLDGGGSGSVSSAQPVAGGAG 836
                   |:|..|.|:  :.:|:  ||          ||....:||...||.:....:|   ||.
Human   352 PRGVPCFRTPLGPLSS--RSAPA--SPNHAGVLSAHSSGAQTPESLSREGSPAPLEPEP---GAA 409

  Fly   837 VPAAAAV-----ALSTPTK--SNGLALANGASQATNAARP 869
            .|..|.:     |.|.|..  |:...|.....|...|.:|
Human   410 QPKLAVIQEARFAQSAPGSPLSSQPVLITVQRQLPQAIKP 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHES-1-likeNP_511071.3 FH_FOXN2-like 700..775 CDD:410805 37/75 (49%)
FOXK2NP_004505.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 5/7 (71%)
FHA_FOXK2 35..157 CDD:438775 20/136 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 85..104 1/18 (6%)
Required for interaction with DVL2 and SUDS3. /evidence=ECO:0000269|PubMed:25805136 129..171 10/50 (20%)
COG5025 <180..577 CDD:227358 96/385 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..260 19/139 (14%)
FH_FOXK2 256..353 CDD:410829 43/96 (45%)
DNA-binding, major groove. /evidence=ECO:0000269|PubMed:16624804 300..318 12/17 (71%)
DNA-binding, minor groove. /evidence=ECO:0000269|PubMed:16624804 328..332 3/3 (100%)
DNA-binding, minor groove. /evidence=ECO:0000269|PubMed:16624804 348..353 0/4 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 359..407 14/54 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..632
Blue background indicates that the domain is not in the aligned region.

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