Protein Alignment CHES-1-like and FOXO1

DIOPT Version :10

• Sequence 1: NP_511071.3
• Gene: CHES-1-like / 31678
• FlyBaseID: FBgn0029504
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_002006.2
• Gene: FOXO1 / 2308
• HGNCID: 3819
• Length: 655
• Species: Homo sapiens
• Alignment Length: 726
• Identity: 165/726 - (22%)
• Similarity: 263/726 - (36%)
• Gaps: 193/726 - (26%)

  Fly   518 LP-PGYSFVNQVASTPHVLSTPAHVASPETPPGAALLPGTYYATSTTSAGTTTTTLQARSLQLSV 581
            || |.:|..|...|:|    .|:..|: ..|..||.||      |.::|..:...:...|| |..
Human    27 LPRPEFSQSNSATSSP----APSGSAA-ANPDAAAGLP------SASAAAVSADFMSNLSL-LEE 79

  Fly   582 S---PPPPNMTPTSQVHNGSLGGGGGGGGGSGGGGGGGGANLRSPNSYASYDNEDSLKEFDLVVS 643
            |   |..|          ||:.........:...||..|                   :|....:
Human    80 SEDFPQAP----------GSVAAAVAAAAAAAATGGLCG-------------------DFQGPEA 115

  Fly   644 SRLHTSTPQYSVSKNGANGYGNGNSNVNGSGAGSNTPQKQKHPNNVPYDPLVHTNNKPPYSFSSL 708
            ..||.:.||     ....|..:.:..|..:.||....|.:|..::       ..|.....|::.|
Human   116 GCLHPAPPQ-----PPPPGPLSQHPPVPPAAAGPLAGQPRKSSSS-------RRNAWGNLSYADL 168

  Fly   709 IFMAIEGSNEKALPVKEIYAWIVQHFPYFK-----TAPNGWKNSVRHNLSLNKSFVKVEKAPNMG 768
            |..|||.|.||.|.:.:||.|:|:..||||     .:..|||||:||||||:..|::|:. ...|
Human   169 ITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQN-EGTG 232

  Fly   769 KGSLWRVEPQQRQNLIQALNRSPFFPNSAVDKISPSLKSPS-GGSAYDSLDGGGSGSVSSAQPVA 832
            |.|.|.:.|:..::     .:||....:::|..|...||.| ......||..|..|:
Human   233 KSSWWMLNPEGGKS-----GKSPRRRAASMDNNSKFAKSRSRAAKKKASLQSGQEGA-------- 284

  Fly   833 GGAGVPAAAAVALSTPTKSNGLALANGASQATNAAR-PHSPNGGGSGSHARFDPYLFPNLSKAFR 896
                                      |.|..:..:: |.||     |||:..|   |.|.| .||
Human   285 --------------------------GDSPGSQFSKWPASP-----GSHSNDD---FDNWS-TFR 314

  Fly   897 ---NIREDTVG---QPMLQDALDDELSGDYHNNNNNNSGSKYNYMGANGSGGAGSGGVGSNANGA 955
               :....|:.   .|::.:. ||...||.|:.....|.:|.                      |
Human   315 PRTSSNASTISGRLSPIMTEQ-DDLGEGDVHSMVYPPSAAKM----------------------A 356

  Fly   956 SDGINFARLARDCGADSIDDVHAAAAMLYLKHGPKIYSEPFQNGSGPVITSSPSEDHTYSAGGNS 1020
            |...:.:.::.....:::.|      .|.|...|...:...|:..|.::..:|.  ::::....|
Human   357 STLPSLSEISNPENMENLLD------NLNLLSSPTSLTVSTQSSPGTMMQQTPC--YSFAPPNTS 413

  Fly  1021 -NADSGSSTPLTNGNALAS-----VAQAVAQGQNNQGGAGSDSNCA----SSDAAYDSSEENHNI 1075
             |:.|.:....|.|.:..|     ..|.:...:::.||. |..|||    ......||...|..:
Human   414 LNSPSPNYQKYTYGQSSMSPLPQMPIQTLQDNKSSYGGM-SQYNCAPGLLKELLTSDSPPHNDIM 477

  Fly  1076 TPEEMADRQRHRDGVDALLSLSGSSIVEC-GSVATTHYHSNGSSGSSHGSP-HKRASS------- 1131
            ||.:....|.:...:...:.:..:|::.. ||.|:   |:...:.|||..| |.:.:|
Human   478 TPVDPGVAQPNSRVLGQNVMMGPNSVMSTYGSQAS---HNKMMNPSSHTHPGHAQQTSAVNGRPL 539

  Fly  1132 -HSLEE-EHLQ-QHREQQLQQQQQQQQHHHQQF----GSSQAVYTNGSGSKMALLSSAAANVALA 1189
             |::.. .|.. .:|..|::...|....|..|.    |.|.....||.| :|.||
Human   540 PHTVSTMPHTSGMNRLTQVKTPVQVPLPHPMQMSALGGYSSVSSCNGYG-RMGLL---------- 593

  Fly  1190 QQQQQQIHQDM 1200
              .|:::..|:
Human   594 --HQEKLPSDL 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_511071.3	FH_FOXN2-like	700..775	CDD:410805	35/79 (44%)
FOXO1	NP_002006.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		15/46 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..158		10/53 (19%)
		FH_FOXO1	151..249	CDD:410834	38/110 (35%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	211..218		5/6 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..344		34/158 (22%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	234..237		1/2 (50%)
		Nuclear localization signal	251..253		0/1 (0%)
		Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0	283..563		67/357 (19%)
		Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0	363..459		19/104 (18%)
		FOXO_KIX_bdg	423..504	CDD:465228	17/81 (21%)
		Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0	462..466		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	507..537		10/32 (31%)
		FOXO-TAD	597..633	CDD:435506	1/6 (17%)