DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHES-1-like and FOXM1

DIOPT Version :9

Sequence 1:	NP_001259311.1	Gene:	CHES-1-like / 31678	FlyBaseID:	FBgn0029504	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_973731.1	Gene:	FOXM1 / 2305	HGNCID:	3818	Length:	801	Species:	Homo sapiens

Alignment Length:	733	Identity:	146/733 - (19%)
Similarity:	227/733 - (30%)	Gaps:	212/733 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 REKMHVQMDHSSHVASTVTVVSSPASSNNSSISSSNTGSVSGSGSSTAAVNGGNSP--------- 460
            |.::.:.:.::....|......|||...::...:|...:.|.|....|.:...|.|
Human    13 RRRLPLPVQNAPSETSEEEPKRSPAQQESNQAEASKEVAESNSCKFPAGIKIINHPTMPNTQVVA 77

  Fly   461 VPKTSSFSTVFEAVNYATSAASNSSSSSNSTPNSQAILHGQESPAVVTTTTLISAGTLPPGYSFV 525
            :|..::..::.      |:..:....|.:|.||.               ..|||.|
Human    78 IPNNANIHSII------TALTAKGKESGSSGPNK---------------FILISCG--------- 112

  Fly   526 NQVASTPHVLSTPAHVASPETPPGAALLPGTYYATSTTSAGTTTTTLQARSLQLSVSPPPPNMTP 590
                            .:|..|||  |.|.|..:........|..||..:.....|:.|.|....
Human   113 ----------------GAPTQPPG--LRPQTQTSYDAKRTEVTLETLGPKPAARDVNLPRPPGAL 159

  Fly   591 TSQVHNGSLGGGGGGGGGSGGGGGGGGANLRSPNSYASYDNEDSLKEFDLVVSSRLHTSTPQYSV 655
            ..|...            :...|...|..:.:     |..|...|::
Human   160 CEQKRE------------TCADGEAAGCTINN-----SLSNIQWLRK------------------ 189

  Fly   656 SKNGANGYGNGNSNVNGSGAGSNT-PQKQKHPNNV-----------PYDPLVHTNN----KPPYS 704
                          ::..|.||.: .|:.:...|.           |..|.....|    :||||
Human   190 --------------MSSDGLGSRSIKQEMEEKENCHLEQRQVKVEEPSRPSASWQNSVSERPPYS 240

  Fly   705 FSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFK-TAPNGWKNSVRHNLSLNKSFVKVEKAPNMG 768
            :.::|..||..:..|.:.:|:||.||..|||||| .|..|||||:||||||:..||: |.:.| |
Human   241 YMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRHNLSLHDMFVR-ETSAN-G 303

  Fly   769 KGSLWRVEPQQRQNLIQALNRSPFFPNS--AVDKISPSLKSPS-----GGSAYDSLDGGGSGSVS 826
            |.|.|.:.|...:.|.......|..|.|  ..:.:....|.|:     ..:....|..|....:.
Human   304 KVSFWTIHPSANRYLTLDQVFKPLDPGSPQLPEHLESQQKRPNPELRRNMTIKTELPLGARRKMK 368

  Fly   827 SAQPVAGGAGVPAAAAVALS---TPTKSNGLALANGASQATNAARPHSPNGGGSGSHARFDPYLF 888
            ...|......||....|..|   .|:....|.||  ||..::....||       ...|..|.:|
Human   369 PLLPRVSSYLVPIQFPVNQSLVLQPSVKVPLPLA--ASLMSSELARHS-------KRVRIAPKVF 424

  Fly   889 PNLSKAFRNIREDTVGQPMLQDALDDELSGDYHNNNNNNSGSKYNY--------MGANGSGGAGS 945
                           |:.::...:....|||..:.....: |.:|:        :...|.....|
Human   425 ---------------GEQVVFGYMSKFFSGDLRDFGTPIT-SLFNFIFLCLSVLLAEEGIAPLSS 473

  Fly   946 GGVGSN-----ANGASDGINFARLARDCGADSIDDVHAAAAMLYLKHGPKIYSEPFQNGSGPVIT 1005
            .|.|..     ..|.|..:....:..       :::.....|.:|....|:.|.|.:....|..:
Human   474 AGPGKEEKLLFGEGFSPLLPVQTIKE-------EEIQPGEEMPHLARPIKVESPPLEEWPSPAPS 531

  Fly  1006 SSPSEDHTYSAGGNSNADSGSS-TPLTNGNALASVAQAVAQGQNNQGGAGSDSNCASSDAAYDSS 1069
            ......|::.       ||..| ||               :.:.:..|..|.:.|.|
Human   532 FKEESSHSWE-------DSSQSPTP---------------RPKKSYSGLRSPTRCVS-------- 566

  Fly  1070 EENHNITPEEMADRQRHR 1087
             |...|...|..:|.|.|
Human   567 -EMLVIQHRERRERSRSR 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_001259311.1	Forkhead	700..785	CDD:278670	41/85 (48%)
FOXM1	NP_973731.1	FH	236..311	CDD:238016	39/76 (51%)
FOXM1	NP_973731.1	Herpes_ICP4_C	504..>749	CDD:332854	22/111 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910