Protein Alignment CHES-1-like and FOXC2

DIOPT Version :10

• Sequence 1: NP_511071.3
• Gene: CHES-1-like / 31678
• FlyBaseID: FBgn0029504
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_005242.1
• Gene: FOXC2 / 2303
• HGNCID: 3801
• Length: 501
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 142/641 - (22%)
• Similarity: 200/641 - (31%)
• Gaps: 239/641 - (37%)

  Fly   652 QYSVSKNGANG----------------YG---------NGNSNVNGSGAGSNTPQKQKHPNNVPY 691
            :||||...|.|                ||         :|:.....:|.|.:......|....|.
Human     4 RYSVSDPNALGVVPYLSEQNYYRAAGSYGGMASPMGVYSGHPEQYSAGMGRSYAPYHHHQPAAPK 68

  Fly   692 DPLVHTNNKPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNK 756
            | ||    |||||:.:||.|||:.:.||.:.:..||.:|:..||:::....||:||:|||||||:
Human    69 D-LV----KPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNE 128

  Fly   757 SFVKV---EKAPNMGKGSLWRVEPQQRQNLIQ---ALNRSPFFPNSAVDKISPS---LKSPSGGS 812
            .||||   :|.|  ||||.|.::|.. .|:.:   .|.|...|....|.|....   ||.|
Human   129 CFVKVPRDDKKP--GKGSYWTLDPDS-YNMFENGSFLRRRRRFKKKDVSKEKEERAHLKEP---- 186

  Fly   813 AYDSLDGGGSGSVSSAQPVAGGAGVPA--------------------AAAVALSTPTKSNGLALA 857
                             |.|...|.||                    ||:.||...||...|: .
Human   187 -----------------PPAASKGAPATPHLADAPKEAEKKVVIKSEAASPALPVITKVETLS-P 233

  Fly   858 NGASQATNAARPHSPNGGGSGS---HARFDPYLFPNLSKAFRNIREDTVGQPMLQDALDDELSGD 919
            ..|.|.:..:...:|.|...||   |....|...|..|  ..||.......|
Human   234 ESALQGSPRSAASTPAGSPDGSLPEHHAAAPNGLPGFS--VENIMTLRTSPP------------- 283

  Fly   920 YHNNNNNNSGSKYNYMGANGSGGAGSGGVGSNANGASDGINFARLARDCGADSIDDVHAAAAMLY 984
                            |...|.|||..|:                           |....|:.|
Human   284 ----------------GGELSPGAGRAGL---------------------------VVPPLALPY 305

  Fly   985 LKHGPKIYSEPFQNGSGPVITSSPSEDHTYSAGGNSNADSGSSTPLTNGNALASVAQAVAQGQNN 1049
            ....|..|.:|                                               .|||.
Human   306 AAAPPAAYGQP-----------------------------------------------CAQGL-- 321

  Fly  1050 QGGAGSDSNCA-SSDAAYDSSEE-NHNITP----EEMADRQRHRDGVDALLSLSGSSIVECGSVA 1108
            :.||.....|: .:.:.|..:|. .|...|    |.::|   |..|..:.||....:..:.|::|
Human   322 EAGAAGGYQCSMRAMSLYTGAERPAHMCVPPALDEALSD---HPSGPTSPLSALNLAAGQEGALA 383

  Fly  1109 TT-HYHSNGSSGSSHGSPHKRAS--------------------------SHSLEEEHLQQHREQQ 1146
            .| |:|.:      ||..|.:|.                          :||.:..||..|   .
Human   384 ATGHHHQH------HGHHHPQAPPPPPAPQPQPTPQPGAAAAQAASWYLNHSGDLNHLPGH---T 439

  Fly  1147 LQQQQQQQQHHHQQFGSSQAVYTNGSGSKMALLSSAAANVALAQQQQQQIHQDMYS 1202
            ...|||...:..:.|.|.:....|.:..:..:..:|:..:..........|...||
Human   440 FAAQQQTFPNVREMFNSHRLGIENSTLGESQVSGNASCQLPYRSTPPLYRHAAPYS 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_511071.3	FH_FOXN2-like	700..775	CDD:410805	39/77 (51%)
FOXC2	NP_005242.1	FH_FOXC1	67..159	CDD:410818	45/99 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..208		11/61 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	232..268		8/36 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..420		8/42 (19%)