DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CHES-1-like and FOXI1

DIOPT Version :9

Sequence 1:	NP_001259311.1	Gene:	CHES-1-like / 31678	FlyBaseID:	FBgn0029504	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_036320.2	Gene:	FOXI1 / 2299	HGNCID:	3815	Length:	378	Species:	Homo sapiens

Alignment Length:	397	Identity:	99/397 - (24%)
Similarity:	154/397 - (38%)	Gaps:	135/397 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   580 SVSPPPPNM------------TPTSQVHNGSLGGGGGGGGGSGGGGGGGGANLRSPNSYASYDNE 632
            |:...||.|            .|:.|  ..|..|||..|.              :||.|..::..
Human    20 SIGQEPPEMNLYYENFFHPQGVPSPQ--RPSFEGGGEYGA--------------TPNPYLWFNGP 68

  Fly   633 DSLKEFDLVVSSRLHTST-PQYSVSKNGA----NGYGNGN---SNVNGSGAGSN-----TPQKQK 684
                           |.| |.|....|.:    ..||...   .:|:|.| ||:     .|.:::
Human    69 ---------------TMTPPPYLPGPNASPFLPQAYGVQRPLLPSVSGLG-GSDLGWLPIPSQEE 117

  Fly   685 HPNNVPYDPLVHTNNKPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVR 749
            ....|          :||||:|:||.|||.|:.:|.|.:.:||.::..:||::..:..||:||:|
Human   118 LMKLV----------RPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIR 172

  Fly   750 HNLSLNKSFVKVEK-APNMGKGSLWRVEP--------------QQRQNLIQALNRSPFFPNSAVD 799
            ||||||..|.||.: ..:.|||:.|.::|              ::|::.:.:...|     .|::
Human   173 HNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSTAS-----LALE 232

  Fly   800 KISPSL--KSPSGGSAYDSLDG---GGSGSVSSAQPVAGGAGVPA--------AAAVALSTPTK- 850
            |...||  .||......|.|||   ||:.|....:|....:|.|.        .|.|:..:||.
Human   233 KTESSLPVDSPKTTEPQDILDGASPGGTTSSPEKRPSPPPSGAPCLNSFLSSMTAYVSGGSPTSH 297

  Fly   851 ----------------SNGLALANGASQATNAARPHSPNGGGSGSH--------------ARFDP 885
                            .|.|.. |..|..||.:. ||  |||..::              ::|.|
Human   298 PLVTPGLSPEPSDKTGQNSLTF-NSFSPLTNLSN-HS--GGGDWANPMPTNMLSYGGSVLSQFSP 358

  Fly   886 YLFPNLS 892
            :.:.:::
Human   359 HFYNSVN 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_001259311.1	Forkhead	700..785	CDD:278670	37/99 (37%)
FOXI1	NP_036320.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		1/5 (20%)
		FH	123..211	CDD:214627	36/87 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..278		18/74 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820