DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHES-1-like and FOXD4

DIOPT Version :9

Sequence 1:	NP_001259311.1	Gene:	CHES-1-like / 31678	FlyBaseID:	FBgn0029504	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_997188.2	Gene:	FOXD4 / 2298	HGNCID:	3805	Length:	439	Species:	Homo sapiens

Alignment Length:	434	Identity:	105/434 - (24%)
Similarity:	148/434 - (34%)	Gaps:	129/434 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   664 GNGNSNVNGSGAGSNTPQKQKHPNNVPYDPLVHTNNKPPYSFSSLIFMAIEGSNEKALPVKEIYA 728
            |.|.|:.:..|.....|.:....:.....|.     |||.|:.:||.|||..|..|.|.:..|.|
Human    73 GGGPSDPSEFGTEFRAPPRSAAASEDARQPA-----KPPSSYIALITMAILQSPHKRLTLSGICA 132

  Fly   729 WIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKVEKAPNM-GKGSLWRVEPQ-----------QRQ 781
            :|...|||::.....|:||:|||||||..|||:.:.|.. |||:.|.::|.           :|:
Human   133 FISDRFPYYRRKFPAWQNSIRHNLSLNDCFVKIPREPGRPGKGNYWSLDPASQDMFDNGSFLRRR 197

  Fly   782 NLIQALNRSPF------FPNSAVDKISPSLKSPSGGSAYDSLDGGGSGSVSSAQPVAG-----GA 835
            ...|....:|.      ||..|.   ..:|.:|..|...        |:.:..|||.|     |.
Human   198 KRFQRHQPTPGAHLPHPFPLPAA---HAALHNPRPGPLL--------GAPAPPQPVPGAYPNTGP 251

  Fly   836 GVPAAAA--------VALSTPTKSNGLALANGASQATNAARPHSPNGGGSGSHARFDPYLFPNL- 891
            |....|.        :.||.|..:.....|.||..||.|..|..            .|:|..:|
Human   252 GRRPYALLHPHPPRYLLLSAPAYAGAPKKAEGADLATPAPFPCC------------SPHLVLSLG 304

  Fly   892 --SKAFRNIREDTVGQPMLQDALDDELSGDYHNNNNNNSGSKYNYMGANGSGGAGSGGVGSNANG 954
              ::.:|..||.......|:                         :...|||....|
Human   305 RRARVWRRHREADASLSALR-------------------------VSCKGSGERVQG-------- 336

  Fly   955 ASDGINFARLARDC----GADSIDDVHAAAAMLYLKHGPKIYSEPFQNGSGPVITSSPSEDHTYS 1015
                     |.|.|    ||.:.......|....|:...:...|...||..|          |..
Human   337 ---------LRRVCPRPRGATAPCSSDRQACRTILQQQQRHQEEDCANGCAP----------TKG 382

  Fly  1016 A--GGNSNADSG--SSTPLTNGNALASVAQAVAQGQNNQGGAGS 1055
            |  ||:.:|.|.  ....:..|:.|.|:|..:       ||.|:
Human   383 AVLGGHLSAASALLRYQAVAEGSGLTSLAAPL-------GGEGT 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_001259311.1	Forkhead	700..785	CDD:278670	38/96 (40%)
FOXD4	NP_997188.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..104		6/35 (17%)
		Forkhead	104..189	CDD:306709	37/84 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..232		7/31 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910