DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHES-1-like and FOXC1

DIOPT Version :9

Sequence 1:	NP_001259311.1	Gene:	CHES-1-like / 31678	FlyBaseID:	FBgn0029504	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001444.2	Gene:	FOXC1 / 2296	HGNCID:	3800	Length:	553	Species:	Homo sapiens

Alignment Length:	640	Identity:	163/640 - (25%)
Similarity:	237/640 - (37%)	Gaps:	178/640 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   572 LQARSLQLSVSPPPP-NMTPTSQVHNGSLGGGGGGGGGSGGGGGGGGANLRSPNSYASYDNEDSL 635
            :|||   .|||.|.. .:.|       .|||.......:....|||...:.:|.|..|:
Human     1 MQAR---YSVSSPNSLGVVP-------YLGGEQSYYRAAAAAAGGGYTAMPAPMSVYSH------ 49

  Fly   636 KEFDLVVSSRLHTSTPQYSVSKNGANGYGNGNSNVNGSGAGSNTPQKQKHPNNVPYDPLVHTNNK 700
                           |.:      |..|..|.:.    ..|..|||.|      |.|.:     |
Human    50 ---------------PAH------AEQYPGGMAR----AYGPYTPQPQ------PKDMV-----K 78

  Fly   701 PPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKV---E 762
            ||||:.:||.|||:.:.:|.:.:..||.:|:..||:::....||:||:|||||||:.||||   :
Human    79 PPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDD 143

  Fly   763 KAPNMGKGSLWRVEPQQRQNLIQ----ALNRSPFFPNSAV------DKISPSLKSPSG----GSA 813
            |.|  ||||.|.::|.. .|:.:    ...|..|....||      |::......|.|    .:.
Human   144 KKP--GKGSYWTLDPDS-YNMFENGSFLRRRRRFKKKDAVKDKEEKDRLHLKEPPPPGRQPPPAP 205

  Fly   814 YDSLDGGGSG-----------------SVSSAQPV--AGGAGVPAAAAVALSTPTKSNGLALANG 859
            .:..||...|                 ..|..||:  |...|..:||||.......|:..:|::|
Human   206 PEQADGNAPGPQPPPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAAAVPKIESPDSSSSSLSSG 270

  Fly   860 ASQ--ATNAARPHSPNGGGSGSHARFDPYLFPNLSKAFR--NIREDTVGQPMLQDALDDELS--- 917
            :|.  :..:|||.|.:|..|...........|:.|:.|.  ||.....|.|....|   |||
Human   271 SSPPGSLPSARPLSLDGADSAPPPPAPSAPPPHHSQGFSVDNIMTSLRGSPQSAAA---ELSSGL 332

  Fly   918 ------------------GDYHNNNNNNSGSKYNYMGANGSGGAGSGGVGSNANGASDGINFARL 964
                              |.|....::...|..:...:.||.|.|.||.|: |.||.....:
Human   333 LASAAASSRAGIAPPLALGAYSPGQSSLYSSPCSQTSSAGSSGGGGGGAGA-AGGAGGAGTY--- 393

  Fly   965 ARDCGADSIDDVHAAAAMLYLKHGP-----KIYSEPFQNGSGPVITSSPSEDHTYSAGGNSNADS 1024
              .|...::....|.....:|:..|     ....:|..:.|.|.:|||.|...::..||...
Human   394 --HCNLQAMSLYAAGERGGHLQGAPGGAGGSAVDDPLPDYSLPPVTSSSSSSLSHGGGGGGG--- 453

  Fly  1025 GSSTPLTNGNALASVAQAVAQGQ------NNQGG-AGSDSNCASSDAA--YDSSEEN-HNITPEE 1079
                   .|...|....|..||:      |..|| .|..::.|::.||  |...::| |::  .|
Human   454 -------GGGQEAGHHPAAHQGRLTSWYLNQAGGDLGHLASAAAAAAAAGYPGQQQNFHSV--RE 509

  Fly  1080 MADRQRHRDGVDALLSLSGSSIVECGSVATTHYHSNGSSGSSHGSPHKRASSHSL 1134
            |.:.||        :.|:.|.:             ||:|......|    ||.||
Human   510 MFESQR--------IGLNNSPV-------------NGNSSCQMAFP----SSQSL 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_001259311.1	Forkhead	700..785	CDD:278670	40/87 (46%)
FOXC1	NP_001444.2	Required for transcriptional activation. /evidence=ECO:0000269\|PubMed:11782474	1..51		17/80 (21%)
		FH	78..166	CDD:214627	40/90 (44%)
		Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000269\|PubMed:11782474	78..93		10/14 (71%)
		Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000269\|PubMed:11782474	168..176		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..310		31/136 (23%)
		Required for transcriptional inhibition. /evidence=ECO:0000269\|PubMed:11782474	215..366		34/153 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..387		9/31 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..465		12/60 (20%)
		Required for transcriptional activation. /evidence=ECO:0000269\|PubMed:11782474	466..553		26/101 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010