Protein Alignment CHES-1-like and FOXK1

DIOPT Version :10

• Sequence 1: NP_511071.3
• Gene: CHES-1-like / 31678
• FlyBaseID: FBgn0029504
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001032242.1
• Gene: FOXK1 / 221937
• HGNCID: 23480
• Length: 733
• Species: Homo sapiens
• Alignment Length: 838
• Identity: 164/838 - (19%)
• Similarity: 248/838 - (29%)
• Gaps: 323/838 - (38%)

  Fly   494 SQAILHGQESPAVVTTTTLISAGTLPPGYSFVNQVASTPHVLSTPAHVASPETPPGAALLPGTYY 558
            ::|:|..:.:|.........:|...|         |:.|     |...|.|:.|||..
Human    10 ARALLALRSAPCSPVLCAAAAAAAFP---------AAAP-----PPAPAQPQPPPGPP------- 53

  Fly   559 ATSTTSAGTTTTTLQARSLQLSVSPPPPNMTPTSQVHNGSLGGGGGGGGGSGGGGGGGGAN---- 619
                                   .||||.:.|      |::.|.|..||.||..|....|.
Human    54 -----------------------PPPPPPLPP------GAIAGAGSSGGSSGVSGDSAVAGAAPA 89

  Fly   620 ----------------------------LRSP-------NSYASYDNEDSLKEFDLVVSSR---L 646
                                        :|.|       :|..|.|....|..|   :|.|   |
Human    90 LVAAAAASVRQSPGPALARLEGREFEFLMRQPSVTIGRNSSQGSVDLSMGLSSF---ISRRHLQL 151

  Fly   647 HTSTPQYSVSKNGANGYGNGNSNVNGSGAGSNTPQKQ---------------------KHPNNVP 690
            ....|.:.:...|.||.     .|:|:......|..|                     .|....|
Human   152 SFQEPHFYLRCLGKNGV-----FVDGAFQRRGAPALQLPKQCTFRFPSTAIKIQFTSLYHKEEAP 211

  Fly   691 YDPL-----------VH------------------------------------------------ 696
            ..||           :|
Human   212 ASPLRPLYPQISPLKIHIPEPDLRSMVSPVPSPTGTISVPNSCPASPRGAGSSSYRFVQNVTSDL 276

  Fly   697 -------------------------TNNKPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPY 736
                                     ..:|||:|::.||..||..:.::.|.:..|||.|.:|:||
Human   277 QLAAEFAAKAASEQQADTSGGDSPKDESKPPFSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPY 341

  Fly   737 FKTAPNGWKNSVRHNLSLNKSFVKVEKA-PNMGKGSLWRVEPQQRQNLI-QALN----------R 789
            ::||..||:||:|||||||:.|:||.:: ...||||.||::|.....|: ||..          |
Human   342 YRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASEAKLVEQAFRKRRQRGVSCFR 406

  Fly   790 SPFFPNSA----VDKISPSLKSPSGGS--------------AYDSLDGGGSGSVSSAQPVAGGAG 836
            :||.|.|:    .....|.|.||..|.              .:|...|....||...:......|
Human   407 TPFGPLSSRSAPASPTHPGLMSPRSGGLQTPECLSREGSPIPHDPEFGSKLASVPEYRYSQSAPG 471

  Fly   837 VPAAA-AVALSTPTKSNGLALANGASQATNAARPHSPNGGGSGSHARFDPYLFPNLSKAFRNIRE 900
            .|.:| .|.::.|.:.:.|.....|....:......|.|     ||.......|.::.    :|.
Human   472 SPVSAQPVIMAVPPRPSSLVAKPVAYMPASIVTSQQPAG-----HAIHVVQQAPTVTM----VRV 527

  Fly   901 DTVGQPMLQDALDDELSGDYHNNNNNNSGSKYNYMGANG----SGGAGSGGVGSNANGASD--GI 959
            .|                   .:.|:.:|......||.|    :.||....:||.|.|..:  .|
Human   528 VT-------------------TSANSANGYILTSQGAAGGSHDAAGAAVLDLGSEARGLEEKPTI 573

  Fly   960 NFA--------------RLARDCGADSIDDVHAAAAMLYLKHGPKIYSEPFQNGSGPVITSSPSE 1010
            .||              ::|......::..:..|..:...:|...:.:.. |||...|.|:
Human   574 AFATIPAAGGVIQTVASQMAPGVPGHTVTILQPATPVTLGQHHLPVRAVT-QNGKHAVPTN---- 633

  Fly  1011 DHTYSAGGNSNA----------DSGSSTPLTNGNALASVAQAVAQGQNNQGGAGSDSNCASSDAA 1065
                |..||:.|          .:.||.|:        |...|.:....:..|...:...::.|.
Human   634 ----SLAGNAYALTSPLQLLATQASSSAPV--------VVTRVCEVGPKEPAAAVAATATTTPAT 686

  Fly  1066 YDSSEENHNITPEEMADRQRHRDGVDALLSLSGSSIVECGSVATTHYHSNGSSGSSHG 1123
            ..::..:.:.|.|....|.|..:.       ||:.....|.:|..     |..|...|
Human   687 ATTASASASSTGEPEVKRSRVEEP-------SGAVTTPAGVIAAA-----GPQGPGTG 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_511071.3	FH_FOXN2-like	700..775	CDD:410805	37/75 (49%)
FOXK1	NP_001032242.1	Interaction with SIN3A and SIN3B. /evidence=ECO:0000250|UniProtKB:P42128	2..40		7/43 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..79		20/83 (24%)
		Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000250|UniProtKB:P42128	95..420		70/332 (21%)
		FHA_FOXK1	103..205	CDD:438774	18/109 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..306		0/18 (0%)
		FH_FOXK1	303..403	CDD:410828	42/99 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..436		6/22 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..733		12/69 (17%)