DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CHES-1-like and FOXK1

DIOPT Version :9

Sequence 1:NP_001259311.1 Gene:CHES-1-like / 31678 FlyBaseID:FBgn0029504 Length:1268 Species:Drosophila melanogaster
Sequence 2:NP_001032242.1 Gene:FOXK1 / 221937 HGNCID:23480 Length:733 Species:Homo sapiens


Alignment Length:838 Identity:164/838 - (19%)
Similarity:248/838 - (29%) Gaps:323/838 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   494 SQAILHGQESPAVVTTTTLISAGTLPPGYSFVNQVASTPHVLSTPAHVASPETPPGAALLPGTYY 558
            ::|:|..:.:|.........:|...|         |:.|     |...|.|:.|||..       
Human    10 ARALLALRSAPCSPVLCAAAAAAAFP---------AAAP-----PPAPAQPQPPPGPP------- 53

  Fly   559 ATSTTSAGTTTTTLQARSLQLSVSPPPPNMTPTSQVHNGSLGGGGGGGGGSGGGGGGGGAN---- 619
                                   .||||.:.|      |::.|.|..||.||..|....|.    
Human    54 -----------------------PPPPPPLPP------GAIAGAGSSGGSSGVSGDSAVAGAAPA 89

  Fly   620 ----------------------------LRSP-------NSYASYDNEDSLKEFDLVVSSR---L 646
                                        :|.|       :|..|.|....|..|   :|.|   |
Human    90 LVAAAAASVRQSPGPALARLEGREFEFLMRQPSVTIGRNSSQGSVDLSMGLSSF---ISRRHLQL 151

  Fly   647 HTSTPQYSVSKNGANGYGNGNSNVNGSGAGSNTPQKQ---------------------KHPNNVP 690
            ....|.:.:...|.||.     .|:|:......|..|                     .|....|
Human   152 SFQEPHFYLRCLGKNGV-----FVDGAFQRRGAPALQLPKQCTFRFPSTAIKIQFTSLYHKEEAP 211

  Fly   691 YDPL-----------VH------------------------------------------------ 696
            ..||           :|                                                
Human   212 ASPLRPLYPQISPLKIHIPEPDLRSMVSPVPSPTGTISVPNSCPASPRGAGSSSYRFVQNVTSDL 276

  Fly   697 -------------------------TNNKPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPY 736
                                     ..:|||:|::.||..||..:.::.|.:..|||.|.:|:||
Human   277 QLAAEFAAKAASEQQADTSGGDSPKDESKPPFSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPY 341

  Fly   737 FKTAPNGWKNSVRHNLSLNKSFVKVEKA-PNMGKGSLWRVEPQQRQNLI-QALN----------R 789
            ::||..||:||:|||||||:.|:||.:: ...||||.||::|.....|: ||..          |
Human   342 YRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASEAKLVEQAFRKRRQRGVSCFR 406

  Fly   790 SPFFPNSA----VDKISPSLKSPSGGS--------------AYDSLDGGGSGSVSSAQPVAGGAG 836
            :||.|.|:    .....|.|.||..|.              .:|...|....||...:......|
Human   407 TPFGPLSSRSAPASPTHPGLMSPRSGGLQTPECLSREGSPIPHDPEFGSKLASVPEYRYSQSAPG 471

  Fly   837 VPAAA-AVALSTPTKSNGLALANGASQATNAARPHSPNGGGSGSHARFDPYLFPNLSKAFRNIRE 900
            .|.:| .|.::.|.:.:.|.....|....:......|.|     ||.......|.::.    :|.
Human   472 SPVSAQPVIMAVPPRPSSLVAKPVAYMPASIVTSQQPAG-----HAIHVVQQAPTVTM----VRV 527

  Fly   901 DTVGQPMLQDALDDELSGDYHNNNNNNSGSKYNYMGANG----SGGAGSGGVGSNANGASD--GI 959
            .|                   .:.|:.:|......||.|    :.||....:||.|.|..:  .|
Human   528 VT-------------------TSANSANGYILTSQGAAGGSHDAAGAAVLDLGSEARGLEEKPTI 573

  Fly   960 NFA--------------RLARDCGADSIDDVHAAAAMLYLKHGPKIYSEPFQNGSGPVITSSPSE 1010
            .||              ::|......::..:..|..:...:|...:.:.. |||...|.|:    
Human   574 AFATIPAAGGVIQTVASQMAPGVPGHTVTILQPATPVTLGQHHLPVRAVT-QNGKHAVPTN---- 633

  Fly  1011 DHTYSAGGNSNA----------DSGSSTPLTNGNALASVAQAVAQGQNNQGGAGSDSNCASSDAA 1065
                |..||:.|          .:.||.|:        |...|.:....:..|...:...::.|.
Human   634 ----SLAGNAYALTSPLQLLATQASSSAPV--------VVTRVCEVGPKEPAAAVAATATTTPAT 686

  Fly  1066 YDSSEENHNITPEEMADRQRHRDGVDALLSLSGSSIVECGSVATTHYHSNGSSGSSHG 1123
            ..::..:.:.|.|....|.|..:.       ||:.....|.:|..     |..|...|
Human   687 ATTASASASSTGEPEVKRSRVEEP-------SGAVTTPAGVIAAA-----GPQGPGTG 732

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHES-1-likeNP_001259311.1 Forkhead 700..785 CDD:278670 40/86 (47%)
FOXK1NP_001032242.1 Interaction with SIN3A and SIN3B. /evidence=ECO:0000250|UniProtKB:P42128 2..40 7/43 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..79 20/83 (24%)
Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000250|UniProtKB:P42128 95..420 70/332 (21%)
FHA <102..204 CDD:224630 18/109 (17%)
FHA 110..203 CDD:238017 18/100 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..306 0/18 (0%)
Forkhead 305..391 CDD:278670 40/85 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 413..436 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 676..733 12/69 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG2294
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270467at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45881
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.010

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