Protein Alignment CHES-1-like and Foxk1

DIOPT Version :10

• Sequence 1: NP_511071.3
• Gene: CHES-1-like / 31678
• FlyBaseID: FBgn0029504
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_951031.2
• Gene: Foxk1 / 17425
• MGIID: 1347488
• Length: 719
• Species: Mus musculus
• Alignment Length: 781
• Identity: 177/781 - (22%)
• Similarity: 275/781 - (35%)
• Gaps: 235/781 - (30%)

  Fly   500 GQESPAVVTTTTLISAGTLP--PGYSFVNQVASTPHVLSTPAHVASPETPPGAALLPGTYYATST 562
            |::|.|    ..|::..:.|  |........|:.|...|.|.....|..||.....||.....||
Mouse     5 GEDSGA----RALLALRSAPCSPVLCAAAAAAAFPATTSPPPPAQPPPGPPALPAEPGPGPVPST 65

  Fly   563 TSAGTTTTTLQARSLQLSV--SPPP----------------PNMTPTSQVHNGS----------- 598
            .:..|||......:...||  ||.|                |::|.......||
Mouse    66 VATATTTAPALVAAAAASVRQSPGPALARLEGREFEFLMRQPSVTIGRNSSQGSVDLSMGLSSFI 130

  Fly   599 ------------------LGGGGGGGGGSGGGGGGGGANL------RSPNS-----YAS-YDNED 633
                              ||..|....|:....|.....|      |.|::     :.| |..|:
Mouse   131 SRRHLQLSFQEPHFYLRCLGKNGVFVDGAFQRRGAPALQLPQQCTFRFPSTAIKIQFTSLYHKEE 195

  Fly   634 S------------------LKEFDL-VVSSRLHTSTPQYSVSKN-GANGYGNGNS------NVNG 672
            :                  :.|.|| .:.|.:.:.|...||..: .|:..|.|:|      ||..
Mouse   196 APASPLRPLYPQISPLKIHIPEPDLRSLVSPIPSPTGTISVPNSCPASPRGAGSSSYRFVQNVTS 260

  Fly   673 --------SGAGSNTPQKQKHPNNVPYDPLVHTNNKPPYSFSSLIFMAIEGSNEKALPVKEIYAW 729
                    :...::..|......:.|.|     .:|||||::.||..||..:.::.|.:..|||.
Mouse   261 DLQLAAEFAAKAASEQQADASGGDSPKD-----ESKPPYSYAQLIVQAISSAQDRQLTLSGIYAH 320

  Fly   730 IVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKVEKA-PNMGKGSLWRVEPQQRQNLI-QALN---- 788
            |.:|:||::||..||:||:|||||||:.|:||.:: ...||||.||::|.....|: ||..
Mouse   321 ITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASEAKLVEQAFRKRRQ 385

  Fly   789 ------RSPFFPNSA----VDKISPSLKSP--SGGSAYDSLDGGGS--------GSVSSAQP--- 830
                  |:||.|.|:    .....|.|.||  ||....:.|...||        ||..::.|
Mouse   386 RGVSCFRTPFGPLSSRSAPASPTHPGLMSPRSSGLQTPECLSREGSPIPHDPDLGSKLASVPEYR 450

  Fly   831 ---VAGGAGVPAAAAVALSTPTKSNGLALANGASQATNAARPHSPNGGGSGSHARFDPYLFPNLS 892
               .|.|:.| :|..|.::.|.:.:.|.....|....:......|:|     ||.......|.::
Mouse   451 YSQSAPGSPV-SAQPVIMAVPPRPSNLVAKPVAYMPASIVTSQQPSG-----HAIHVVQQAPTVT 509

  Fly   893 KAFRNIREDTVGQPMLQDALDDELSGDYHNNNNNNSGSKYNYMGANGSGG-----AGSG--GVGS 950
            .    :|..|                     .:.||.:.| .:.:.||.|     ||:.  .:|:
Mouse   510 M----VRVVT---------------------TSANSANGY-ILASQGSTGTSHDTAGTAVLDLGN 548

  Fly   951 NANGASD--GINFA--------------RLARDCGADSIDDVHAAAAMLYLKHGPKIYSEPFQNG 999
            .|.|..:  .|.||              ::|......::..:..|..:...:|...:.:.. |||
Mouse   549 EARGLEEKPTIAFATIPAASRVIQTVASQMAPGVPGHTVTILQPATPVTIGQHHLPVRAVT-QNG 612

  Fly  1000 SGPVITSSPSEDHTYSAGGNS----------NADSGSSTPLTNGNALASVAQAVAQGQNNQGGAG 1054
            ...|.|:|.:        ||:          .|.:.||||:.       :.:....|......|.
Mouse   613 KHAVPTNSLT--------GNAYALSSPLQLLAAQASSSTPVV-------ITRVCEVGPEEPAAAV 662

  Fly  1055 S-DSNCASSDAAYDSSEENHNITPEEMADRQRHRDGVDALLSLSGSSIVECGSVATTHYHSNGSS 1118
            | .:|.|.:.||..::..:.:..||                 :..|.:.|.|..|||...:..::
Mouse   663 SVAANAAPTPAASTTTSASSSGEPE-----------------VKRSRVEEPGGTATTQPTAMAAT 710

  Fly  1119 G 1119
            |
Mouse   711 G 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_511071.3	FH_FOXN2-like	700..775	CDD:410805	38/75 (51%)
Foxk1	NP_951031.2	Interaction with SIN3A and SIN3B. /evidence=ECO:0000269|PubMed:10620510, ECO:0000269|PubMed:22476904	2..40		8/38 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..67		10/31 (32%)
		Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000269|PubMed:22956541	81..406		84/329 (26%)
		FHA	89..191	CDD:469597	14/101 (14%)
		FH_FOXK1	289..389	CDD:410828	43/99 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..443		12/43 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	665..719		13/64 (20%)