DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHES-1-like and Foxc1

DIOPT Version :9

Sequence 1:	NP_001259311.1	Gene:	CHES-1-like / 31678	FlyBaseID:	FBgn0029504	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_032618.2	Gene:	Foxc1 / 17300	MGIID:	1347466	Length:	553	Species:	Mus musculus

Alignment Length:	737	Identity:	173/737 - (23%)
Similarity:	242/737 - (32%)	Gaps:	296/737 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   572 LQARSLQLSVSPPPP-NMTPTSQVHNGSLGGGGGGGGGSGGGGGGGGANLRSPNSYASYDNEDSL 635
            :|||   .|||.|.. .:.|       .|||.......:....|||...:.:|.|
Mouse     1 MQAR---YSVSSPNSLGVVP-------YLGGEQSYYRAAAAAAGGGYTAMPAPMS---------- 45

  Fly   636 KEFDLVVSSRLHTSTPQYSVSKNGANGYGNGNSNVNGSGAGSNTPQKQKHPNNVPYDPLVHTNNK 700
                 |.|...|..  ||..|.  |..|            |..|||.|      |.|.:     |
Mouse    46 -----VYSHPAHAE--QYPGSM--ARAY------------GPYTPQPQ------PKDMV-----K 78

  Fly   701 PPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKV---E 762
            ||||:.:||.|||:.:.:|.:.:..||.:|:..||:::....||:||:|||||||:.||||   :
Mouse    79 PPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDD 143

  Fly   763 KAPNMGKGSLWRVEPQQ-----------------------------RQNL--------------- 783
            |.|  ||||.|.::|..                             |.:|
Mouse   144 KKP--GKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAVKDKEEKGRLHLQEPPPPQAGRQPAPA 206

  Fly   784 ------------------IQALNR---------SPFFPNSAVDKIS----PSLKSPSGGSAYDSL 817
                              ||.:..         .|..|.:|:...|    |.::||...|:  ||
Mouse   207 PPEQAEGSAPGPQPPPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAATVPKIESPDSSSS--SL 269

  Fly   818 DGGGS--GSVSSAQPVAGGAGVPAAAAVALSTPTKSNGLALANGASQATNAARPHSPNGGGSGSH 880
            ..|.|  ||:.||:|::..|..||........|..|.|.::.|..:         |..|...||.
Mouse   270 SSGSSPPGSLPSARPLSLDAAEPAPPPQPAPPPHHSQGFSVDNIMT---------SLRGSPQGSA 325

  Fly   881 ARFDPYLFPNLSKAFRNIREDTVGQPMLQDALDDELSGDYHNNNNNNSGSKYNYMGANGSGGAGS 945
            |.....|..:.:.:.|    ..:..|:...|.....|..|.:..:.:|.:     |::|.||.|.
Mouse   326 AELGSGLLASAAASSR----AGIAPPLALGAYSPGQSSLYSSPCSQSSSA-----GSSGGGGGGG 381

  Fly   946 GGVGSNANGASDGINFARLARDCGADSIDDVHAAAAMLYLKHGPKIYSEPFQNGSGPVITSSPSE 1010
            ||.|.:::.|..|
Mouse   382 GGGGGSSSAAGTG---------------------------------------------------- 394

  Fly  1011 DHTYSAGGNSNADSGSSTPLTNGNALASVAQAVAQG--QNNQGGAGSDSNCASSDAAYDSSEENH 1073
                          |::|...|..|::..|.....|  |...|||||        ||.|....::
Mouse   395 --------------GAATYHCNLQAMSLYAAGERGGHLQGPAGGAGS--------AAVDDPLPDY 437

  Fly  1074 NITPEEMADRQRHRDGVDALLSLSGSSIVECGSVATTHYHSNGSSGSSHGSPHKRASSHSLEEEH 1138
            ::.|                              ||    |:.||..|||...:.||.|...
Mouse   438 SLPP------------------------------AT----SSSSSSLSHGGGGQEASHHPAS--- 465

  Fly  1139 LQQHREQQLQQQQQQQQHHHQQFGSSQAVYTNGSGSKMALLSSAAANVALA--QQQQQQIH--QD 1199
                               ||  |...:.|.|.:|..:..|:||||..|.|  ..|||..|  ::
Mouse   466 -------------------HQ--GRLTSWYLNQAGGDLGHLASAAAAAAAAGYPGQQQNFHSVRE 509

  Fly  1200 MY-SSTAGHNASMYLGGLNSHC 1220
            |: |...|.|.|...|  ||.|
Mouse   510 MFESQRIGLNNSPVNG--NSSC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_001259311.1	Forkhead	700..785	CDD:278670	41/149 (28%)
Foxc1	NP_032618.2	Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q12948	1..51		18/74 (24%)
		FH	78..166	CDD:214627	39/89 (44%)
		Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000250\|UniProtKB:Q12948	78..93		10/14 (71%)
		Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000250\|UniProtKB:Q12948	168..176		0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..326		32/163 (20%)
		Required for transcriptional inhibition. /evidence=ECO:0000250\|UniProtKB:Q12948	217..366		37/163 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..393		12/41 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..466		20/109 (18%)
		Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q12948	466..553		26/68 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820