Protein Alignment CHES-1-like and Foxg1

DIOPT Version :10

• Sequence 1: NP_511071.3
• Gene: CHES-1-like / 31678
• FlyBaseID: FBgn0029504
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_032267.1
• Gene: Foxg1 / 15228
• MGIID: 1347464
• Length: 481
• Species: Mus musculus
• Alignment Length: 567
• Identity: 132/567 - (23%)
• Similarity: 197/567 - (34%)
• Gaps: 200/567 - (35%)

  Fly   461 VPKTSSF---STVFEAVNYATSAASNSSSSSNSTPNSQAILHGQESPAVVTTTTLISAGTLPPGY 522
            :|| |||   |.|.|||......||:...:|:...:.....|....|              ||
Mouse    13 IPK-SSFSINSLVPEAVQNDNHHASHGHHNSHHPQHHHHHHHHHHPP--------------PP-- 60

  Fly   523 SFVNQVASTPHVLSTPAHVASPETPPGAALLPGTYYATSTTSAGTTTTTLQARSLQLSVSP--PP 585
                  |..|   ..|......:.||.|...|                  |||....:...  |.
Mouse    61 ------APQP---PPPPPQQQQQQPPPAPQPP------------------QARGAPAADDDKGPQ 98

  Fly   586 PNMTPTSQVHNGSLGGGGGGGGGSGGGGGGGGANLRSPNSYASYDNEDSLKEFDLVVSSRLHTST 650
            |.:.|.|...:|:.....|..|..|||          |...|....::..|
Mouse    99 PLLLPPSTALDGAKADALGAKGEPGGG----------PAELAPVGPDEKEK-------------- 139

  Fly   651 PQYSVSKNGANGYGNGNSNVNGSGAGSNTPQ--KQKHPNNVPYDPLVHTNNKPPYSFSSLIFMAI 713
                       |.|.|.....|:|.|....:  |:....|..|:       |||:|:::||.|||
Mouse   140 -----------GAGAGGEEKKGAGEGGKDGEGGKEGDKKNGKYE-------KPPFSYNALIMMAI 186

  Fly   714 EGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKVEK-APNMGKGSLWRVEP 777
            ..|.||.|.:..||.:|:::|||::....||:||:||||||||.||||.: ..:.|||:.|.::|
Mouse   187 RQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDP 251

  Fly   778 --------------QQRQNLIQA-----------------LNR--SPFFPNSAVDKISP--SLKS 807
                          ::|....:|                 ::|  |.::|      :||  ||..
Mouse   252 SSDDVFIGGTTGKLRRRSTTSRAKLAFKRGARLTSTGLTFMDRAGSLYWP------MSPFLSLHH 310

  Fly   808 PSGGSAYDSLDGGGSGSVSSAQPVAGGAGVPAAAAVALSTPTKSNGLALANGAS--QATNAARPH 870
            |...|   :|...|:.|...:.|      :|.::.:..::...::..:.|||.|  :..|...|:
Mouse   311 PRASS---TLSYNGTTSAYPSHP------MPYSSVLTQNSLGNNHSFSTANGLSVDRLVNGEIPY 366

  Fly   871 S-------------PNGGG---SGSHARFDP-----------YLFPNL-----------SKAFRN 897
            :             |.|..   ||::: .:|           |.||::           |.:.|.
Mouse   367 ATHHLTAAALAASVPCGLSVPCSGTYS-LNPCSVNLLAGQTSYFFPHVPHPSMTSQTSTSMSARA 430

  Fly   898 IREDTVGQ--------------PMLQDALDDELSGDYHNNNNNNSGS 930
            ....|..|              |.....|...|| ||..:.|..|.|
Mouse   431 ASSSTSPQAPSTLPCESLRPSLPSFTTGLSGGLS-DYFTHQNQGSSS 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_511071.3	FH_FOXN2-like	700..775	CDD:410805	39/75 (52%)
Foxg1	NP_032267.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..173		39/226 (17%)
		FH_FOXG	173..251	CDD:410795	39/77 (51%)
		COG5025	<176..>348	CDD:227358	53/186 (28%)
		Required for interaction with TLE6. /evidence=ECO:0000269|PubMed:16314515	241..336		21/109 (19%)
		Interaction with KDM5B. /evidence=ECO:0000250	375..398		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..447		4/27 (15%)