DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHES-1-like and Foxm1

DIOPT Version :9

Sequence 1:	NP_001259311.1	Gene:	CHES-1-like / 31678	FlyBaseID:	FBgn0029504	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_032047.4	Gene:	Foxm1 / 14235	MGIID:	1347487	Length:	757	Species:	Mus musculus

Alignment Length:	721	Identity:	147/721 - (20%)
Similarity:	222/721 - (30%)	Gaps:	313/721 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 TPTRTTMVGHGYMPVVVSSA-------------SQPILSPAKQQLPQQIYVTSNGSSPAGGGTIY 374
            :|.|..::....:|:.|.:|             :||  .||..|..|::..:|:...|||
Mouse     4 SPRRPLILKRRRLPLPVQNAPSETSEEEAKRSPAQP--EPAPAQASQEVAESSSCKFPAG----- 61

  Fly   375 KAASQALSSPTTSSSSSSNTTTHHPHKKYLREKMHVQMDHSSHVASTVTVVSSPASSNNSSISSS 439
               .:.::.|||.::.                                 ||:.|::::..||.::
Mouse    62 ---IKIINHPTTPNTQ---------------------------------VVAIPSNADIQSIITA 90

  Fly   440 NTGSVSGSGSSTAAVNGGNSPVPKTSSFSTVFEAVNYATSAASNSSSSSNSTPNSQAILHGQESP 504
            .|.....||||     |.|..:
Mouse    91 LTAKGKESGSS-----GPNRFI------------------------------------------- 107

  Fly   505 AVVTTTTLISAGTLPPGYSFVNQVASTPHVLSTPAHVASPETPPGAALLPGTYYATSTTSAGTTT 569
                   |||:|                          .|.:.|..   |..:.:..:..|...|
Mouse   108 -------LISSG--------------------------GPSSHPSQ---PQAHSSRDSKRAEVIT 136

  Fly   570 TTLQARSLQLSVSPPPPNMTPTSQVHNGSLGGGGGG-------------GGGSGGGGGGGGANLR 621
            .||..:.....|..|.|...|..|......||...|             |..|..|.|.
Mouse   137 ETLGPKPAAKGVPVPKPPGAPPRQRQESYAGGEAAGCTLDNSLTNIQWLGKMSSDGLGP------ 195

  Fly   622 SPNSYASYDNEDSLKEFDLVVSSRLHTSTPQYSVSKNGANGYGNGNSNVNGSGAGSNTPQKQKHP 686
                 .|...|...||...:..:|:....|                |.|:.|...|
Mouse   196 -----CSVKQELEEKENCHLEQNRVKVEEP----------------SGVSTSWQDS--------- 230

  Fly   687 NNVPYDPLVHTNNKPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFK-TAPNGWKNSVRH 750
                      .:.:||||:.::|..||..:..|.:.:|:||.||..|||||| .|..|||||:||
Mouse   231 ----------VSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRH 285

  Fly   751 NLSLNKSFVKVEKAPNMGKGSLWRVEP-----------------------------QQRQNLIQA 786
            ||||:..||: |.:.| ||.|.|.:.|                             |:|.|  ..
Mouse   286 NLSLHDMFVR-ETSAN-GKVSFWTIHPSANRYLTLDQVFKPLEPGSPQSPEHLESQQKRPN--PE 346

  Fly   787 LNRS----------------PFFP-------------NSAVDKISPSLKSPSGGSAYDSLDGGGS 822
            |:|:                |..|             |.:: .:.||:|.|...:|
Mouse   347 LHRNVTIKTEIPLGARRKMKPLLPRVSSYLVPIQFPVNQSL-VLQPSVKVPLPLAA--------- 401

  Fly   823 GSVSSAQPVAGGAGVPAAAAVALSTPTKSNGLALANGASQATNAARPHSPNGGGSGSHARFDPYL 887
             |:.|::.......|..|..|.||    |.|:|    ...||...:...|..||.|        |
Mouse   402 -SLMSSELARHSKRVRIAPKVLLS----SEGIA----PLPATEPPKEEKPLLGGEG--------L 449

  Fly   888 FPNLSKAFRNIRED---------------TVGQPMLQD------ALDDELSGDYHNNN-NNNSGS 930
            .|.|  ..::|:|:               .|..|.|::      :|.:|||..:.::: :.....
Mouse   450 LPLL--PIQSIKEEEMQPEEDIAHLERPIKVESPPLEEWPSPCASLKEELSNSWEDSSCSPTPKP 512

  Fly   931 KYNYMG 936
            |.:|.|
Mouse   513 KKSYCG 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_001259311.1	Forkhead	700..785	CDD:278670	43/114 (38%)
Foxm1	NP_032047.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		11/51 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..167		22/155 (14%)
		FH	234..309	CDD:238016	39/76 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..348		3/26 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..560		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..635
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..709
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910