DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHES-1-like and Foxh1

DIOPT Version :9

Sequence 1:	NP_001259311.1	Gene:	CHES-1-like / 31678	FlyBaseID:	FBgn0029504	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_032015.1	Gene:	Foxh1 / 14106	MGIID:	1347465	Length:	401	Species:	Mus musculus

Alignment Length:	303	Identity:	80/303 - (26%)
Similarity:	115/303 - (37%)	Gaps:	85/303 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   638 FDLVVSSRLHTSTPQYSVSKNGANGY-----GNGNSNVNGSGAG--SNTPQKQKHPNNVPYDPLV 695
            :||..:....|.:||.:::.  |.||     ...||.:....|.  |.||:::|...      |.
Mouse     5 WDLASTYTPTTPSPQLALAP--AQGYLPCMGPRDNSQLRPPEAESLSKTPKRRKKRY------LR 61

  Fly   696 HTNNKPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVK 760
            |  :||||::.::|.:.|:.:..:.|.:.:|...:...||:|:....|||:|:|||||.|:.|.|
Mouse    62 H--DKPPYTYLAMIALVIQAAPFRRLKLAQIIRQVQAVFPFFRDDYEGWKDSIRHNLSSNRCFHK 124

  Fly   761 VEKAP--NMGKGSLWRV-------EPQQRQNLI--------------------QALNRSPFFPNS 796
            |.|.|  ...||:.|.|       |..:.||..                    ..|:..|:.|
Mouse   125 VPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNRGTHRAFAKDLSPYVLHGQPYQP-- 187

  Fly   797 AVDKISPSLKSP--SGGSAYDSLDGGGSGSVSSAQPVAGGAGVP----AAAAVALST-------- 847
                  ||...|  .|.|....|...|..|.....|     |:|    ||.|..||.
Mouse   188 ------PSPPPPPREGFSIKSLLGDPGKESTWPQHP-----GLPGQSTAAQAGTLSKGEEGMGTG 241

  Fly   848 PTKSN-----------GLALANGASQATNAARPHSPNGGGSGS 879
            |:.|:           |..:..|.|......|| ||.....||
Mouse   242 PSSSSETPLWPLCSLPGPTIIEGESSQGEVIRP-SPVTPDQGS 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_001259311.1	Forkhead	700..785	CDD:278670	33/113 (29%)
Foxh1	NP_032015.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..57		6/24 (25%)
		FH	64..142	CDD:238016	29/77 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..251		21/84 (25%)
		SMAD-interaction domain (SID)	307..390
		Fast/FoxH1 motif 1 (FM1)	311..315
		Fast/FoxH1 motif 2 (FM2)	321..327
		SMAD interaction motif (SIM)	363..384
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910