Protein Alignment CHES-1-like and FOXN3

DIOPT Version :9

• Sequence 1: NP_001259311.1
• Gene: CHES-1-like / 31678
• FlyBaseID: FBgn0029504
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001078940.1
• Gene: FOXN3 / 1112
• HGNCID: 1928
• Length: 490
• Species: Homo sapiens
• Alignment Length: 634
• Identity: 164/634 - (25%)
• Similarity: 247/634 - (38%)
• Gaps: 174/634 - (27%)

  Fly   586 PNMTPTSQVHNGSLGGGGGGGGGSGGGGGGGGANLRSPNSYASYD---NEDSLKEFDLVVSSRLH 647
            |.|.|:.:..:..:....|.....||.|............::..|   .|.::::.:|...:.||
Human     3 PVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLH 67

  Fly   648 TSTPQYSVSKNGANGYGNG--NSNVNGSGAGSNTPQKQKHPNNVPYDPLVHTNNKPPYSFSSLIF 710
            .       |||....:|..  .|.........:||....| :::|||...:.|.|||||||.|||
Human    68 E-------SKNLLKSFGESVLRSVSPVQDLDDDTPPSPAH-SDMPYDARQNPNCKPPYSFSCLIF 124

  Fly   711 MAIEGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKV--EKAPNMGKGSLW 773
            ||||.|..|.||||:||.||::|||||..||.||||||||||||||.|.||  |::.::||||||
Human   125 MAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLW 189

  Fly   774 RVEPQQRQNLIQALNRSPFFPNSAVDKISPSLKSPSGGSAYDSLDGGGSGSVSSAQPVAGGAGVP 838
            .::|:.||||||||.::|:.|:..|....|:..     .||.|         :|..|:..|
Human   190 CIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCP-----QAYQS---------TSGPPIWPG---- 236

  Fly   839 AAAAVALSTPTKSNGLALANGASQATNAA----RPHSPNGGGSGSHARFDPYLFPN----LSKA- 894
                   ||..|.||..|.:....|.:|.    .|.....|       |.|.:..|    ||:.
Human   237 -------STFFKRNGALLQDPDIDAASAMMLLNTPPEIQAG-------FPPGVIQNGARVLSRGL 287

  Fly   895 FRNIREDTVGQPMLQDALDDELSGDYHNNNNNNSGSKYNYMGANGSGGAGSGGVGSNANGASDGI 959
            |..:|...:..                                          :|..| ...:||
Human   288 FPGVRPLPITP------------------------------------------IGVTA-AMRNGI 309

  Fly   960 NFARLARDCGADSIDDVHAAAAMLYLKHGPKIYSEPFQNGSGPVITSSPSEDHTYSAGGNSNADS 1024
            ...|:..:                         |||  :...||::..|.|||.||:..:|||.|
Human   310 TSCRMRTE-------------------------SEP--SCGSPVVSGDPKEDHNYSSAKSSNARS 347

  Fly  1025 GSST--PLTNGNALASVAQAVAQGQNNQGGAGSDSNCASSDAAYDSSEENHNITPEEMADRQRHR 1087
            .|.|  .:::.::.|......|...:.:|..||:.:..|.::..|:.|::...:.:|..|
Human   348 TSPTSDSISSSSSSADDHYEFATKGSQEGSEGSEGSFRSHESPSDTEEDDRKHSQKEPKD----- 407

  Fly  1088 DGVDALLSLSGSSIVECGSVATTHYHSNGSSGSSHGSPHKRASSHSLEEEHLQQHREQQLQQQQQ 1152
                                      |.|.||  :.|.||:       .:|..:.|:........
Human   408 --------------------------SLGDSG--YASQHKK-------RQHFAKARKVPSDTLPL 437

  Fly  1153 QQQHHHQQFGSSQAVYTNGSGSKMAL------LSSAAANVALAQQQQQQ 1195
            :::...:...|........:||.:.|      |::.....|..|::|::
Human   438 KKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKE 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHES-1-like	NP_001259311.1	Forkhead	700..785	CDD:278670	60/86 (70%)
FOXN3	NP_001078940.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		3/17 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	86..108		6/22 (27%)
		Forkhead	114..201	CDD:278670	60/86 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	315..458		37/209 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5426
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41006
orthoMCL	1	0.900	-	-		OOG6_108124
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5832
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.790