DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9657 and Slc5a7

DIOPT Version :9

Sequence 1:	NP_001284983.1	Gene:	CG9657 / 31674	FlyBaseID:	FBgn0029950	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_445973.2	Gene:	Slc5a7 / 85426	RGDID:	69270	Length:	580	Species:	Rattus norvegicus

Alignment Length:	601	Identity:	129/601 - (21%)
Similarity:	228/601 - (37%)	Gaps:	143/601 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 HVEELRASLQSFGWPDYLVFCLMLAICAVIGIYFCLQLRLESRKQKANGSEEAASSAASYLVGGR 66
            |||.|.|         .::|.|::.:   :||:       .:.|.|.:|:.|..|.|  .:||||
  Rat     4 HVEGLVA---------IILFYLLIFL---VGIW-------AAWKTKNSGNAEERSEA--IIVGGR 47

  Fly    67 QMKIFPITMSLISSFISGITLLGTPTEVYLYGAQYMYIMG------SLVLMGFCMYYFFLPVFHE 125
            .:.:.....::.::::.|..:.||...||..|....:...      ||:|.|.    ||......
  Rat    48 DIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAWAQAPIGYSLSLILGGL----FFAKPMRS 108

  Fly   126 LNLISTYKYLEQRYNRSLRLFGSVMFIVA---SLLWLPIVIYVPAIAFNQATGVNIHIVTPIVCV 187
            ...::.....:|.|.:.:   |.::||.|   .:.|...:........:....|:::|...:..:
  Rat   109 KGYVTMLDPFQQIYGKRM---GGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIVSAL 170

  Fly   188 VCIFYTCIGGLKAVVWTDVIQTLIMFGAMAL-----VLIKGTLDIGGPGVVWQKAQETARLEVPN 247
            :.|.||.:|||.:|.:|||:|...:|..:.:     :......|||...|       .|:.:.|.
  Rat   171 IAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIGFTAV-------HAKYQSPW 228

  Fly   248 F-SADLSERYT----FYSLVLGGVAHWLKSNAISQNMIQRYLSLPTLRDARIAIWTFIAG----V 303
            . :.:..|.||    |..|:|||:. |       |...||.||..:...|::.  :|:|.    |
  Rat   229 LGTIESIEVYTWLDNFLLLMLGGIP-W-------QAYFQRVLSSSSATYAQVL--SFLAAFGCLV 283

  Fly   304 LAFLMIC-GYTGLLI---YATYSQCDPLETKLAQRNDQLLPLLVMDTLGSYPGLPGVFVAGVFSA 364
            :|...|| |..|...   ...|...||   |..:..|.:||:::......|....|  :..|.:|
  Rat   284 MALPAICIGAIGASTDWNQTAYGFPDP---KTKEEADMILPIVLQYLCPVYISFFG--LGAVSAA 343

  Fly   365 ALSSLSTGLNSLSAVVLEDFVKTFRKSPLTEGQTAFVMRSVVVVFGIIFVALVFAVEKLGAVLQL 429
            .:||..:.:.|.|::...:..:...:...::.:..:|||..|.|||....|:....:.:..:..|
  Rat   344 VMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYL 408

  Fly   430 TITLSSVANGP--LLGIFTAGVMLPWVNSKGALLGGFSSLIVMAWMCVSAQRDLVTGDLVY---- 488
            :..|..:...|  |..:|..|     .|:.||:.|....|.:.           :||...|
  Rat   409 SSDLVYIIIFPQLLCVLFIKG-----TNTYGAVAGYIFGLFLR-----------ITGGEPYLYLQ 457

  Fly   489 -----------------KRKPYSTMGCNYTFAGEPREFASLALDGAISSVPSAPFQLYRISYLY- 535
                             :|.|:.|:....:|      |.::.:.             |...||:
  Rat   458 PLIFYPGYYPDKNGIYNQRFPFKTLSMVTSF------FTNICVS-------------YLAKYLFE 503

  Fly   536 -------FTLFGALVT 544
                   ..:|.|:|:
  Rat   504 SGTLPPKLDIFDAVVS 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9657	NP_001284983.1	SLC5sbd_NIS-SMVT	16..554	CDD:271383	124/587 (21%)
Slc5a7	NP_445973.2	SLC5sbd_CHT	8..495	CDD:271368	120/558 (22%)
Slc5a7	NP_445973.2	Mediates interaction with SEC14L1. /evidence=ECO:0000269\|PubMed:17092608	502..580		3/18 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340281
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740