Protein Alignment rumpel and Slc5a3

DIOPT Version :10

• Sequence 1: NP_572397.1
• Gene: rumpel / 31674
• FlyBaseID: FBgn0029950
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_059087.2
• Gene: Slc5a3 / 53881
• MGIID: 1858226
• Length: 718
• Species: Mus musculus
• Alignment Length: 615
• Identity: 140/615 - (22%)
• Similarity: 237/615 - (38%)
• Gaps: 172/615 - (27%)

  Fly    23 LMLAICAVIGIYFCLQLRLE-SRKQKANGSEEAASSAASYLVGGRQMKIFPITMSLISSFISG-- 84
            |..|..||:.:||.|.:.:. ....|:|     .|:.:.|.:.||.|....|..||..|.|..
Mouse     5 LEAADIAVVALYFILVMCIGFFAMWKSN-----RSTVSGYFLAGRSMTWVAIGASLFVSNIGSEH 64

  Fly    85 -ITLLGTPTEVYLYGAQYMYIMGS--------LVLMGFCMYYFFLPVFHELNLISTYKYLEQRY- 139
             |.|.|:       ||...:.:|:        |.|:|    :.|:|::....:.:..:||.:|:
Mouse    65 FIGLAGS-------GAASGFAVGAWEFNALLLLQLLG----WVFIPIYIRSGVYTMPEYLSKRFG 118

  Fly   140 -NRSLRLFGSVMFIVASLLWLPIVIYVPAIAFNQATGVNIHIVTPIVCVVCIFYTCIGGLKAVVW 203
             :|....|.::..::.....|.:.:|..|:...::.|.|:::...::..:....|..|||.||::
Mouse   119 GHRIQVYFAALSLLLYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVAVIY 183

  Fly   204 TDVIQTLIM-FGAMALVLIKGTLDIGG------------PGV----------------VWQKAQE 239
            ||.:|.|:| .||:.|::| ..:.|||            |.|                |..||..
Mouse   184 TDTLQALLMIIGALTLMVI-SMVKIGGFEEVKRRYMLASPDVASILLKYNLSNTNACMVHPKANA 247

  Fly   240 TARLEVPNFSADLSERYTFYSLVLG----GVAHWLKSNAISQNMIQRYLSLPTLRDARIAIWTFI 300
            ...|..|.     .|...:...:||    .|.:|    ...|.::||.|:...:..|:.:  |.:
Mouse   248 LKMLRDPT-----DEDVPWPGFILGQTPASVWYW----CADQVIVQRVLAAKNIAHAKGS--TLM 301

  Fly   301 AGVLAFL-----MICGYTGLLIYATYSQCDPLETKLAQRNDQLLPLLVMDTLGS--------YP- 351
            ||.|..|     ::.|....:::|....|             :.|...|...||        ||
Mouse   302 AGFLKLLPMFIIVVPGMISRIVFADEIAC-------------INPEHCMQVCGSRAGCSNIAYPR 353

  Fly   352 --------GLPGVFVAGVFSAALSSLSTGLNSLSAVVLEDFVKTFRKSPLTEGQTAFVMRSVVVV 408
                    ||.|:.:|.:.:|.:|.|.:..||.|.:...|..|..|||..:        |.:::|
Mouse   354 LVMTLVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLIRKSASS--------RELMIV 410

  Fly   409 FGIIFVALV---------FAVEKLGAVLQLTITLSSVAN---GPLLGIFTAGVMLPWVNSKGALL 461
             |.||||.:         ..||..|.  |:.:.:..||:   .|:..:|...:.....|.:||..
Mouse   411 -GRIFVAFMVVISIAWVPIIVEMQGG--QMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFY 472

  Fly   462 GGFSSLIVMAWMCVSAQRDLVTGDLVYKRKPYSTMGCNYTFAGEPREFASLALDGAISSVPSAPF 526
            ||.:..::.|...:.|             ..|....|:     :|               .:.|.
Mouse   473 GGMAGFVLGAVRLILA-------------FTYRAPECD-----QP---------------DNRPG 504

  Fly   527 QLYRISYLY-----FTLFGALVTIVVALVT 551
            .:..|.|:|     |.:.| |:|::|:|:|
Mouse   505 FIKDIHYMYVATALFWITG-LITVIVSLLT 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rumpel	NP_572397.1	SLC5sbd_NIS-SMVT	16..554	CDD:271383	140/615 (23%)
Slc5a3	NP_059087.2	SLC5sbd_SMIT	9..718	CDD:271382	138/611 (23%)