DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9657 and slc5a12

DIOPT Version :9

Sequence 1:	NP_001284983.1	Gene:	CG9657 / 31674	FlyBaseID:	FBgn0029950	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_956662.1	Gene:	slc5a12 / 393339	ZFINID:	ZDB-GENE-040426-1343	Length:	623	Species:	Danio rerio

Alignment Length:	574	Identity:	191/574 - (33%)
Similarity:	315/574 - (54%)	Gaps:	54/574 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DYLVFCLMLAICAVIGIYFCLQLRLESRKQKANGSEEAASSAASYLVGGRQMKIFPITMSLISSF 81
            ||:||..:..:.:.||::|.::     .:.||...|        :|||||||...|:.:||.:||
Zfish    11 DYVVFACLFVVSSGIGVFFAIK-----ERNKAPSKE--------FLVGGRQMSCGPVALSLTASF 62

  Fly    82 ISGITLLGTPTEVYLYGAQYMYIMGSLVLMGFCMYY---FFLPVFHELNLISTYKYLEQRYNRSL 143
            :|.:|::|.|.:||.:||.|: |.|  |...|.:::   .|||||:...:.|||:|||.|:.:.:
Zfish    63 MSAVTVIGAPADVYRFGASYV-IFG--VAYTFVVFFTAELFLPVFYRSGITSTYEYLELRFCKLV 124

  Fly   144 RLFGSVMFIVASLLWLPIVIYVPAIAFNQATGVNIHIVTPIVCVVCIFYTCIGGLKAVVWTDVIQ 208
            |:..::::|:.::|:..:|:|.||:|.||.||.::........:||.||..:||||||||||..|
Zfish   125 RVAATLIYIIQTILYTGVVVYAPALALNQVTGFDLWGSIFATGIVCTFYCTLGGLKAVVWTDAFQ 189

  Fly   209 TLIMFGAMALVLIKGTLDIGGPGVVWQKAQETARLEVPNFSADLSERYTFYSLVLGGVAHWLKSN 273
            .::|......|||:|:...||...||..::...||:|.:|......|:||::|.:||...||...
Zfish   190 MVVMVVGFLTVLIQGSSRAGGIENVWSTSRTGGRLQVFDFDVSPLRRHTFWTLSVGGTFTWLGIY 254

  Fly   274 AISQNMIQRYLSLPTLRDARIAIWTFIAGVLAFLMICGYTGLLIYATYSQCDPLETKLAQRNDQL 338
            .::|:.|||.:|..|...||.|::..:.|:...|.....:||::|:.||.|||..:.|....|||
Zfish   255 GVNQSTIQRCISCKTEGHARWALYLNLLGLWIILFCAVVSGLIMYSYYSHCDPWSSGLISAPDQL 319

  Fly   339 LPLLVMDTLGSYPGLPGVFVAGVFSAALSSLSTGLNSLSAVVLEDFV-KTFRKSPLTEGQTAFVM 402
            :|..||:.||::|||||:|||..||..||:::..:|:|:.|:.|||| :.|  ..|:....:::.
Zfish   320 MPYFVMEILGAFPGLPGLFVACAFSGTLSTVAASINALATVMYEDFVSQCF--PDLSNRAASWIS 382

  Fly   403 RSVVVVFGIIFVALVFAVEKLGAVLQLTITLSSVANGPLLGIFTAGVMLPWVNSKGALLGGFSSL 467
            :::.|.||:....:..|...:|.::|..:::..:..||:||:|:.|::.|:.|.|||:.|....:
Zfish   383 KALCVAFGVACTTMAVAASYMGGIVQAALSIHGMCGGPVLGLFSLGILFPFTNLKGAVGGLIVGI 447

  Fly   468 IVMAWMCVSAQRDLVTGDLVYKRK-------PYSTMGCNYTFAG-EPREFASLALDGAISSVPSA 524
            .:..|:.|        |..:|...       ..:|.|||.|.|. ||       ....::.:.|.
Zfish   448 SLSFWVGV--------GAFIYPAPSNNTHALELNTAGCNITAAAFEP-------TSATVTQLTSD 497

  Fly   525 PFQL----YRISYLYFTLFGALVTIVVALVTSLLLRETDLDGVDTRLLTPFVRR 574
            ...|    |.:||||::..|.:.|:...|:.:||     ...:|.:||.|.:.|
Zfish   498 RNWLADSWYSMSYLYYSAVGFIGTVAAGLLITLL-----TGPMDPKLLKPGMTR 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9657	NP_001284983.1	SLC5sbd_NIS-SMVT	16..554	CDD:271383	184/552 (33%)
slc5a12	NP_956662.1	SLC5sbd_SMCT2	4..533	CDD:212089	186/559 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580131
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950