DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9657 and Slc5a8

DIOPT Version :9

Sequence 1:	NP_001284983.1	Gene:	CG9657 / 31674	FlyBaseID:	FBgn0029950	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_663398.2	Gene:	Slc5a8 / 216225	MGIID:	2384916	Length:	611	Species:	Mus musculus

Alignment Length:	573	Identity:	205/573 - (35%)
Similarity:	318/573 - (55%)	Gaps:	60/573 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WPDYLVFCLMLAICAVIGIYFCLQLRLESRKQKANGSEEAASSAASYLVGGRQMKIFPITMSLIS 79
            | ||:||..||.|.|.||||:..          |.|.::   ::..:|:|||.|...|:.:||.:
Mouse    13 W-DYVVFAGMLLISAAIGIYYAF----------AGGGQQ---TSKDFLMGGRSMSAVPVALSLTA 63

  Fly    80 SFISGITLLGTPTEVYLYGAQYMYIMGSLVLMGFCMYYF---------FLPVFHELNLISTYKYL 135
            ||:|.:|:||||.|||.:||         :...|.:.||         |||||:.|.:.|||:||
Mouse    64 SFMSAVTVLGTPAEVYRFGA---------IFSIFVITYFFVVVISAEVFLPVFYRLGITSTYEYL 119

  Fly   136 EQRYNRSLRLFGSVMFIVASLLWLPIVIYVPAIAFNQATGVNIHIVTPIVCVVCIFYTCIGGLKA 200
            |.|:||.:||.|:::|||.::|:..||||.||:|.||.||.::........|||.||..:|||||
Mouse   120 ELRFNRCIRLCGTILFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKA 184

  Fly   201 VVWTDVIQTLIMFGAMALVLIKGTLDIGGPGVVWQKAQETARLEVPNFSADLSERYTFYSLVLGG 265
            ||||||.|..||....|.|:|:.::...|...:...|....||...||..:..:|:||:::|:||
Mouse   185 VVWTDVFQVGIMVAGFASVIIQASITQHGINKILSDAFNGGRLNFWNFDPNPLQRHTFWTIVIGG 249

  Fly   266 VAHWLKSNAISQNMIQRYLSLPTLRDARIAIWTFIAGVLAFLMICGYTGLLIYATYSQCDPLETK 330
            ...|.....::|:.:|||:|..:...|:::::..:.|:...|....:.||.:|:.|.:|||..:|
Mouse   250 TFTWTTIYGVNQSQVQRYISCKSRLHAKLSLYVNLVGLWVILTCSIFCGLALYSRYRECDPWTSK 314

  Fly   331 LAQRNDQLLPLLVMDTLGSYPGLPGVFVAGVFSAALSSLSTGLNSLSAVVLEDFVKTFRKSPLTE 395
            .....|||:|.||:|.|.:|||:||:|||..:|..||::|:.:|:|:||.:||.:|...|| |:|
Mouse   315 KVSAIDQLMPYLVLDILKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFKS-LSE 378

  Fly   396 GQTAFVMRSVVVVFGIIFVALVFAVEKLGAVLQLTITLSSVANGPLLGIFTAGVMLPWVNSKGAL 460
            ...:::.:.:.|::|.:.:.:......:||:||..:::..:..|||||:|:.|:::|:.||.|||
Mouse   379 KSLSWISQGMSVLYGALCIGMAALASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSIGAL 443

  Fly   461 LGGFSSLIVMAWMCVSAQ-------RDLVTGDLVYKRKPYSTMGCNYTFAGE------PREFASL 512
            .|..:...:..|:.:.||       |.|..        |..|.|||.|..|.      ...|::.
Mouse   444 TGLLAGFAISLWVGIGAQLYPPLPERTLPL--------PLETYGCNITHNGSDWMSTTEMPFSTS 500

  Fly   513 ALDGAISSVPSAPF--QLYRISYLYFTLFGALVTIVVALVTSLLL--RETDLD 561
            |..  |.:....|.  ..|.:|||||:..|.|.|:.|.::.||..  |:.:||
Mouse   501 AFQ--IHNAERTPLMDNWYSLSYLYFSTIGTLTTLFVGILISLSTGGRKQNLD 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9657	NP_001284983.1	SLC5sbd_NIS-SMVT	16..554	CDD:271383	200/561 (36%)
Slc5a8	NP_663398.2	SLC5sbd_SMCT1	7..549	CDD:271402	203/569 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836578
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.850