DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9657 and SLC5A8

DIOPT Version :9

Sequence 1:	NP_001284983.1	Gene:	CG9657 / 31674	FlyBaseID:	FBgn0029950	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_666018.3	Gene:	SLC5A8 / 160728	HGNCID:	19119	Length:	610	Species:	Homo sapiens

Alignment Length:	579	Identity:	204/579 - (35%)
Similarity:	327/579 - (56%)	Gaps:	72/579 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WPDYLVFCLMLAICAVIGIYFCLQLRLESRKQKANGSEEAASSAASYLVGGRQMKIFPITMSLIS 79
            | ||:||..||.|.|.||||:..          |.|.::   ::..:|:|||:|...|:.:||.:
Human    13 W-DYVVFAGMLVISAAIGIYYAF----------AGGGQQ---TSKDFLMGGRRMTAVPVALSLTA 63

  Fly    80 SFISGITLLGTPTEVYLYGAQYMYIMGSLVLMGFCMYYF---------FLPVFHELNLISTYKYL 135
            ||:|.:|:||||:|||.:||         :...|...||         |||||::|.:.|||:||
Human    64 SFMSAVTVLGTPSEVYRFGA---------IFSIFAFTYFFVVVISAEVFLPVFYKLGITSTYEYL 119

  Fly   136 EQRYNRSLRLFGSVMFIVASLLWLPIVIYVPAIAFNQATGVNIHIVTPIVCVVCIFYTCIGGLKA 200
            |.|:|:.:||.|:|:|||.::|:..||||.||:|.||.||.::........|||.||..:|||||
Human   120 ELRFNKCVRLCGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKA 184

  Fly   201 VVWTDVIQTLIMFGAMALVLIKGTLDIGGPGVVWQKAQETARLEVPNFSADLSERYTFYSLVLGG 265
            |:||||.|..||....|.|:|:..:..||...:...|.:..||...||:.:..:|:||:::::||
Human   185 VIWTDVFQVGIMVAGFASVIIQAVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRHTFWTIIIGG 249

  Fly   266 VAHWLKSNAISQNMIQRYLSLPTLRDARIAIWTFIAGVLAFLMICGYTGLLIYATYSQCDPLETK 330
            ...|.....::|:.:|||:|..:...|:::::..:.|:.|.|....:.||.:|:.|..|||...|
Human   250 TFTWTSIYGVNQSQVQRYISCKSRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPWTAK 314

  Fly   331 LAQRNDQLLPLLVMDTLGSYPGLPGVFVAGVFSAALSSLSTGLNSLSAVVLEDFVKTFRKSPLTE 395
            .....|||:|.||:|.|..||||||:|||..:|..||::|:.:|:|:||.:||.:|.:.:| |:|
Human   315 KVSAPDQLMPYLVLDILQDYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRS-LSE 378

  Fly   396 GQTAFVMRSVVVVFGIIFVALVFAVEKLGAVLQLTITLSSVANGPLLGIFTAGVMLPWVNSKGAL 460
            ...:::.:.:.||:|.:.:.:......:||:||..:::..:..|||:|:|..|:::|:.||.|||
Human   379 RSLSWISQGMSVVYGALCIGMAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSIGAL 443

  Fly   461 LGGFSSLIVMAWMCVSAQRDLVTGDLVYKRKPYSTM-------GCNYTFAGEPREFASLALDGAI 518
            :|..:...:..|:.:.||        :|...|..|:       |||.|: .|.....:
Human   444 VGLMAGFAISLWVGIGAQ--------IYPPLPERTLPLHLDIQGCNSTY-NETNLMTT------- 492

  Fly   519 SSVP--SAPFQLYRI------------SYLYFTLFGALVTIVVALVTSLLL--RETDLD 561
            :.:|  ::.||:|.:            |||||:..|.|||::|.::.||..  |:.:||
Human   493 TEMPFTTSVFQIYNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLSTGGRKQNLD 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9657	NP_001284983.1	SLC5sbd_NIS-SMVT	16..554	CDD:271383	199/567 (35%)
SLC5A8	NP_666018.3	SLC5sbd_SMCT1	7..549	CDD:271402	202/575 (35%)
SLC5A8	NP_666018.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..610
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146484
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850