DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9657 and Slc5a5

DIOPT Version :9

Sequence 1:	NP_001284983.1	Gene:	CG9657 / 31674	FlyBaseID:	FBgn0029950	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_444478.2	Gene:	Slc5a5 / 114479	MGIID:	2149330	Length:	618	Species:	Mus musculus

Alignment Length:	597	Identity:	201/597 - (33%)
Similarity:	312/597 - (52%)	Gaps:	37/597 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SFGWPDYLVFCLMLAICAVIGIYFCLQLRLESRKQKANGSEEAASSAASYLVGGRQMKIFPITMS 76
            :||..||.||..||.:...||::..|          |.|.:.   ||..:..||||:...|:.:|
Mouse    11 TFGPWDYGVFATMLLVSTGIGLWVGL----------ARGGQR---SADDFFTGGRQLAAVPVGLS 62

  Fly    77 LISSFISGITLLGTPTEVYLYGAQYMYIMGSLVLMGFCMYYFFLPVFHELNLISTYKYLEQRYNR 141
            |.:||:|.:.:||.|.|...||.:::::....:|........|||:|:.|.|.|||:|||.|::|
Mouse    63 LAASFMSAVQVLGVPAEAARYGLKFLWMCVGQLLNSLLTALLFLPIFYRLGLTSTYQYLELRFSR 127

  Fly   142 SLRLFGSVMFIVASLLWLPIVIYVPAIAFNQATGVNIHIVTPIVCVVCIFYTCIGGLKAVVWTDV 206
            ::||.|::.::||::|:..||||.||:..||.||::|........::|..||.:||:||||||||
Mouse   128 AVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDV 192

  Fly   207 IQTLIMFGAMALVLIKGTLDIGGPGVVWQKAQETARLEVPNFSADLSERYTFYSLVLGGVAHWLK 271
            .|.::|.....::|.:|.:.:|||..|...||..:|:.:.:|..|...||||::.|:||...||.
Mouse   193 FQVVVMLVGFWVILARGVMLMGGPWNVLSLAQNHSRINLMDFDPDPRSRYTFWTFVVGGSLVWLS 257

  Fly   272 SNAISQNMIQRYLSLPTLRDARIAIWTFIAGVLAFLMICGYTGLLIYATYSQCDPLETKLAQRND 336
            ...::|..:|||::..|.|.|::|:.....|:...:......|::::..|..||||.|......|
Mouse   258 MYGVNQAQVQRYVACHTERKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRIAAPD 322

  Fly   337 QLLPLLVMDTLGSYPGLPGVFVAGVFSAALSSLSTGLNSLSAVVLEDFVKTFRKSPLTEGQTAFV 401
            |.:||||:|.....||:||:|:|..:|..||:.||.:|:::||.:||.:|. |...|...:..|:
Mouse   323 QYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKP-RMPSLAPRKLVFI 386

  Fly   402 MRSVVVVFGIIFVALVFAVEKL--GAVLQLTITLSSVANGPLLGIFTAGVMLPWVNSKGALLGGF 464
            .:.:..::|...:. |.|:..|  |.|||.:.|:..|.:|||||.||.|::||..|:.|.|.|..
Mouse   387 SKGLSFIYGSTCLT-VAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLT 450

  Fly   465 SSLIVMAWMCVSAQRDLVTGDLVYKRKPYSTMGC-NYTFAGEPREFAS----LALDGAISSVPSA 524
            :.|.|..|:.|.|.. ...|:......|.|..|| |.:....|...|:    :...|..|..|:.
Mouse   451 AGLAVSLWVAVGATL-YPPGEQTMGVLPTSAAGCTNASVLPSPPGAANTSRGIPSSGMDSGRPAF 514

  Fly   525 PFQLYRISYLYFTLFGALVTIVVALVTSLLLRETDLDGVDTRLLTPFVRRWLERRRHRRSKIPDS 589
            ....|.:||||:...|.|.|::...:.|.|...|....:...||      |.:..|...|..|
Mouse   515 ADTFYAVSYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLL------WWDLARQTASVAP-- 571

  Fly   590 GQKSSNKQETKT 601
                  |::|.|
Mouse   572 ------KEDTTT 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9657	NP_001284983.1	SLC5sbd_NIS-SMVT	16..554	CDD:271383	188/544 (35%)
Slc5a5	NP_444478.2	SLC5sbd_NIS	15..549	CDD:271393	189/549 (34%)
Slc5a5	NP_444478.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	571..618		4/15 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836570
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850