DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18155 and DIP2B

DIOPT Version :9

Sequence 1:	NP_996360.2	Gene:	CG18155 / 31668	FlyBaseID:	FBgn0029945	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_775873.2	Gene:	DIP2B / 57609	HGNCID:	29284	Length:	1576	Species:	Homo sapiens

Alignment Length:	651	Identity:	121/651 - (18%)
Similarity:	217/651 - (33%)	Gaps:	218/651 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 DINGE----YTYFQLYMAAKRLGIQISNICG---------GAALSNVTYLCSNN--ALWIAIQWS 113
            |:.|:    .||.:|:..:.:|...:.|..|         |   ..|..:..||  .:::...:.
Human   360 DMTGKPVYTLTYGKLWSRSLKLAYTLLNKLGTKNEPVLKPG---DRVALVYPNNDPVMFMVAFYG 421

  Fly   114 CWISGQVAVPLE--------SGQAIDQLQRQASNCKTKLLIATKEFESLAQELSQGVKSATIILD 170
            |.::..:.||:|        .||.|..|   ..:|...|        :|..|:.  :|.
Human   422 CLLAEVIPVPIEVPLTRKDAGGQQIGFL---LGSCGIAL--------ALTSEVC--LKG------ 467

  Fly   171 HSFLPTAESVSSTSMYAKQLVAIQG-----VIVTENTF----PNDFY------SKAPAMLIYTPN 220
               ||..::        .::|..:|     .:||::.:    |.|:.      ...||.:.|..:
Human   468 ---LPKTQN--------GEIVQFKGWPRLKWVVTDSKYLSKPPKDWQPHISPAGTEPAYIEYKTS 521

  Fly   221 AVNSPKPVLLTHRNIEAQMRCLIGTWHLGPTDCMLPILS---------------MNRMHAALAAV 270
            ...|...|.::...:.:..:.|....:....:.::.:|.               ||:|| .::..
Human   522 KEGSVMGVTVSRLAMLSHCQALSQACNYSEGETIVNVLDFKKDAGLWHGMFANVMNKMH-TISVP 585

  Fly   271 LSVGGNVVLQ--QKFDGHNAWSALLGINSPSKQRVTLFLAMPIVYKRLIVEYEKMFAKDSRMVEY 333
            .||.....|.  |:...|.|..||:                    |...:.:..|..:|.|.|..
Human   586 YSVMKTCPLSWVQRVHAHKAKVALV--------------------KCRDLHWAMMAHRDQRDVSL 630

  Fly   334 IVNHCRQKIRLMATAFALLPDSV-----FYRWREITGQNIYEYYGMMETGLVLGHPLNKRQRDSP 393
                  ..:|::.......|.||     |.        ::::.:|:....:.
Human   631 ------SSLRMLIVTDGANPWSVSSCDAFL--------SLFQSHGLKPEAIC------------- 668

  Fly   394 HNGPTAV-AMANNTAPNDYRPGTLGSPLKGVTARLISNKG-------------DELITCKNELGG 444
               |.|. |.|...|..  |||..|:||.|  ..::|..|             :..:|.: ::|.
Human   669 ---PCATSAEAMTVAIR--RPGVPGAPLPG--RAILSMNGLSYGVIRVNTEDKNSALTVQ-DVGH 725

  Fly   445 SVDSGLIPVEDIGGDASLAGT-IIGELQIAG--SNLVSNTLANNNQEMEHKGTTNN--EEQENNQ 504
            .:..|::.:....|...|..| .|||:.::.  ..::...||         |.|.|  |....|.
Human   726 VMPGGMMCIVKPDGPPQLCKTDEIGEICVSSRTGGMMYFGLA---------GVTKNTFEVIPVNS 781

  Fly   505 DGFFKTGDICAYRNGNFYFLSKSSDIFTVGGYKVYGSEIKKVLIS--HPNINDVAVLGIP----- 562
            .| ...||:...|:|...|:...|.:|.||  |:.|    .:::|  ..|.:|:...|:.
Human   782 AG-SPVGDVPFIRSGLLGFVGPGSLVFVVG--KMDG----LLMVSGRRHNADDIVATGLAVESIK 839

  Fly   563 ------------NKMWGHRLGVICIVSPDAD--------------ID-LDAIKTYCYRHLPAHKC 600
                        :..:..|:.|:....|||.              || :..:..||...:||:..
Human   840 TVYRGRIAVFSVSVFYDERIVVVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTL 904

  Fly   601 P 601
            |
Human   905 P 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18155	NP_996360.2	CaiC	53..604	CDD:223395	121/651 (19%)
CG18155	NP_996360.2	AFD_class_I	58..607	CDD:302604	121/651 (19%)
DIP2B	NP_775873.2	DMAP_binding	14..131	CDD:283995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..246
		CaiC	336..912	CDD:223395	121/651 (19%)
		AFD_class_I	360..924	CDD:302604	121/651 (19%)
		AMP-binding	995..1470	CDD:278902
		AFD_class_I	1012..1565	CDD:302604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900