DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18155 and dip2cb

DIOPT Version :9

Sequence 1:	NP_996360.2	Gene:	CG18155 / 31668	FlyBaseID:	FBgn0029945	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	XP_005171457.1	Gene:	dip2cb / 569986	ZFINID:	ZDB-GENE-070912-589	Length:	1595	Species:	Danio rerio

Alignment Length:	668	Identity:	113/668 - (16%)
Similarity:	215/668 - (32%)	Gaps:	236/668 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 TYFQLYMAAKRLGIQISNICG---------GAALSNVTYLCSNNALWIAIQWSCWISGQVAVPLE 125
            ||.:|:..:.:|...:.:..|         |..:: :.|..|:.|.::...:.|.::..|.||:|
Zfish   383 TYGKLWSRSLKLAYNLLHKLGSKQEPIIHPGDRVA-LVYPNSDPAAFMVAFYGCLLAEVVPVPIE 446

  Fly   126 -----SGQAIDQLQRQASNCKTKLLIATKE-FESLAQELSQGV-------KSATIILDHSFL--- 174
                 ......|:.....:|...:.:|:.. .:.|.:..|..|       |...::.|...|
Zfish   447 VPLTKKDAGSQQIGFLLGSCGVTVALASDACHKGLPKSASGDVMQFKGWPKLLWVLTDSKHLSKP 511

  Fly   175 -----PTAESVSSTSMYAKQLV----AIQGVIVTENTFPNDFYSKAPAMLIYTPNAVNSPKPVLL 230
                 |..:..::.:.|.:...    ::.|:.||.           .|||.:...         |
Zfish   512 PREWFPLIKDANNDTAYIEYKTCKDGSVMGITVTR-----------MAMLSHCQT---------L 556

  Fly   231 TH----RNIEAQMRCL-----IGTWHLGPTDCMLPILSMNRMHAALAAVLSVGGNVVLQQKFDGH 286
            ||    ...|..:..|     ||.||...|..      :|.:|     |:||.
Zfish   557 THTCGYSEAETVVNVLDFKKGIGLWHSVQTSV------LNMLH-----VVSVP------------ 598

  Fly   287 NAWSALLGINSPSKQRVTLFLAMPIVYKRLIVEYE-KMFAKDSRMVEY-IVNHCRQ------KIR 343
               .||:.:|             |:.:.:.:.:|: |:....||.:.: ::.|..|      .:|
Zfish   599 ---YALMKVN-------------PLSWIQKVCQYKAKVACVKSRDLHWALMAHKEQPDTNMSSLR 647

  Fly   344 LMATAFALLPDSV-----FYRWREITGQNIYEYYGMMETGL--VLGHP------LNKRQRDSPHN 395
            ::..|....|.|:     |.        |:::..|:....:  ..|.|      |.:.|..|...
Zfish   648 MLLIADGSNPWSISSCDAFL--------NVFQNMGLRSEVICPCAGSPEALTVALRRPQESSSKP 704

  Fly   396 GPTAVAMANNTAPNDYRPGT-----------LGSPLKGVTARLISNKGDELITCKNELG----GS 445
            ....|....|.:....|..|           :|:.:.|....::..:|...:...:|:|    .:
Zfish   705 AGRGVLSMTNLSHGVIRVDTGEKLSVLTLQDVGTAMPGAVVCVVKVEGVPQLCKADEIGEICVSA 769

  Fly   446 VDSG---------------LIPVEDIGGDAS--------------------LAGTIIGELQIAG- 474
            |.:|               :.||...||..|                    ::||:.|.:|:.|
Zfish   770 VATGTSYYGLTGMSKNTFEVCPVACDGGLVSDCVFVRSGLLGFVGPGRMIFISGTLEGLMQVGGR 834

  Fly   475 ----SNLVSNTLANNNQEMEHKGTT---------------------NNEEQENNQ---------D 505
                .::::..||....:..::|.|                     ::.|:|:.|         |
Zfish   835 KHNADDIIATALAVEPMKFIYRGRTVVFSVTVLYDERIVLVAEQRPDSTEEESYQWMSRVLQAID 899

  Fly   506 GFFKTGDIC-AYRNGNF--------YFLSKSSDIFTVGGYKVYG---------SEIKKVLISHPN 552
            |..:.|..| |....|.        ..||::..:|..||.....         :.:.|.....|.
Zfish   900 GIHQVGVYCLALVPANTLPKTPLGGIHLSETKQLFLEGGLHPCSILMCPHSCITNLPKPRQKQPE 964

  Fly   553 INDVAVLGIPNKMWGHRL 570
            :...:|: :.|.:.|.|:
Zfish   965 VGPASVM-VGNLVAGKRM 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18155	NP_996360.2	CaiC	53..604	CDD:223395	113/668 (17%)
CG18155	NP_996360.2	AFD_class_I	58..607	CDD:302604	113/668 (17%)
dip2cb	XP_005171457.1	DMAP_binding	6..114	CDD:283995
		CaiC	349..940	CDD:223395	107/624 (17%)
		AFD_class_I	375..937	CDD:302604	105/621 (17%)
		AMP-binding	1005..1489	CDD:278902
		AFD_class_I	1022..1584	CDD:302604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900