DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18155 and Acsf3

DIOPT Version :9

Sequence 1:	NP_996360.2	Gene:	CG18155 / 31668	FlyBaseID:	FBgn0029945	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	XP_574249.5	Gene:	Acsf3 / 498962	RGDID:	1586037	Length:	583	Species:	Rattus norvegicus

Alignment Length:	585	Identity:	154/585 - (26%)
Similarity:	271/585 - (46%)	Gaps:	97/585 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 EERSNVVVPTFKKAMLYPDEIAVKDINGEYTYFQLYMAAKRLGIQISNI--C--GGAALSNVTYL 100
            |.|::...|.|.:|:.:.|.:|:.|.:|.:||.:||..:..|..:|.::  |  |......|::|
  Rat    37 EARTDGSAPVFIRALAFGDRVALIDKHGRHTYRELYDRSLCLAQEICSLRGCKVGDLQEERVSFL 101

  Fly   101 CSNNALWIAIQWSCWISGQVAVPLESGQAIDQLQRQASNCKTKLLIATKEF----ESLAQELSQG 161
            |||:..::..||:.|:||.|||||.......||:....:.::.:::..:|:    ..|||.|...
  Rat   102 CSNDVSYVIAQWASWMSGGVAVPLYRKHPEAQLEYFIQDSRSSVVVVGQEYLERLSPLAQRLGVP 166

  Fly   162 VKSATIILDHSFLPTAESVSSTSMYAKQLVAIQGVIVTENTFPNDFYSKAPAMLIYTPNAVNSPK 226
            :...|..:.|.   .||......:..::                  :....||:.||......||
  Rat   167 LLPLTPAVYHG---AAEKPIEQPIQERE------------------WRDRGAMIFYTSGTTGRPK 210

  Fly   227 PVLLTHRNIEAQMRCLIGTWHLGPTDCMLPILSMNRMHAA---LAAVLSVGGNVVLQQKFDGHNA 288
            ..|.||||:.|.:..|:.:|.....|.:|.:|.::.:|..   |...|.||...|:..:|.....
  Rat   211 GALSTHRNLAAVVTGLVHSWAWTKNDVILHVLPLHHVHGVVNKLLCPLWVGATCVMLPEFSAQQV 275

  Fly   289 WSALLGINSPSKQRVTLFLAMPIVYKRLIVEYEKMFAKDSRMVEYIVNHCRQKIRLMATAFALLP 353
            |...|...:|   ::.:|:|:|.:|.:|:..|::.|.: |.:.:::...|:::||||.:..|.||
  Rat   276 WEKFLSSEAP---QINMFMAVPTIYSKLLDYYDRHFTQ-SHVQDFVRAVCKERIRLMVSGSAALP 336

  Fly   354 DSVFYRWREITGQNIYEYYGMMETGLVLGHPLNKRQRDSPHNGPTAVAMANNTAPNDYRPGTLGS 418
            ..:..:|:..||..:.|.|||.|.|:.|.:||.:.:                      .||::|:
  Rat   337 VPLLEKWKSATGHTLLERYGMTEIGMALSNPLTEAR----------------------VPGSVGT 379

  Fly   419 PLKGVTARLISNKGDELITCKNELGGSVDSGLIPVEDIGGDASLAGTII--------GELQIAGS 475
            ||.||..|::|         :|...||..:       |..:.::.||.:        |||.:.|.
  Rat   380 PLPGVEVRIVS---------ENPQKGSSYT-------IHAEGNMRGTKVTPGFEEKEGELLVKGP 428

  Fly   476 NLVSNTLANNNQEMEHKGTTNNEEQEN--NQDGFFKTGDICAYRNGNFYFLSKSS-DIFTVGGYK 537
            ::.        ||...|    .||.::  ..||:|:|||...:::..::...::| ||...||||
  Rat   429 SVF--------QEYWDK----PEETKSAFTPDGWFRTGDTAVFKDDRYWIRGRTSVDIIKTGGYK 481

  Fly   538 VYGSEIKKVLISHPNINDVAVLGIPNKMWGHRLGVICIVSPDADIDLDAIKTYCYRHLPAHKCPT 602
            |...||::.|::||:|.||||:|:|:..||.|:..:..:.....:....:|.:....|..:..|:
  Rat   482 VSALEIERHLLAHPSITDVAVIGVPDMTWGQRVTAVVALQEGHSLSHRDLKEWARGVLAPYAVPS 546

Fly 603 602
Rat 547 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18155	NP_996360.2	CaiC	53..604	CDD:223395	150/572 (26%)
CG18155	NP_996360.2	AFD_class_I	58..607	CDD:302604	149/567 (26%)
Acsf3	XP_574249.5	CaiC	49..572	CDD:223395	150/573 (26%)
Acsf3	XP_574249.5	MCS	55..564	CDD:213307	149/567 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352931
Domainoid	1	1.000	157	1.000	Domainoid score	I4079
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	211	1.000	Inparanoid score	I3576
OMA	1	1.010	-	-		QHG55233
OrthoDB	1	1.010	-	-		D229996at33208
OrthoFinder	1	1.000	-	-		FOG0002270
OrthoInspector	1	1.000	-	-		oto98639
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24096
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2297
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870