DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18155 and Acsf3

DIOPT Version :9

Sequence 1:	NP_996360.2	Gene:	CG18155 / 31668	FlyBaseID:	FBgn0029945	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_659181.2	Gene:	Acsf3 / 257633	MGIID:	2182591	Length:	583	Species:	Mus musculus

Alignment Length:	610	Identity:	171/610 - (28%)
Similarity:	275/610 - (45%)	Gaps:	104/610 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LCSAELI---HKDGFIEKLRHSF---DEEERSNVVVPTFKKAMLYPDEIAVKDINGEYTYFQLYM 76
            |.|::||   |:.       ||.   ..|..::..||.|.:|:.:.|.||:.|..|.:||.:||.
Mouse    16 LASSQLIPRRHRG-------HSLLPTTPEAHTDGSVPVFIRALAFGDRIALIDKYGHHTYRELYD 73

  Fly    77 AAKRLGIQISNI--C--GGAALSNVTYLCSNNALWIAIQWSCWISGQVAVPLESGQAIDQLQRQA 137
            .:..|..:|..:  |  |......|::||||:..::..||:.|:||.|||||.......||:...
Mouse    74 RSLCLAQEICRLQGCKVGDLQEERVSFLCSNDVSYVVAQWASWMSGGVAVPLYWKHPEAQLEYFI 138

  Fly   138 SNCKTKLLIATKEF----ESLAQELSQGVKSATIILDHSFLPTAESV--SSTSMYAKQLVAIQGV 196
            .:.::.|::..:|:    ..|||.|  ||         ..||...:|  .:|....:|.|...|
Mouse   139 QDSRSSLVVVGQEYLERLSPLAQRL--GV---------PLLPLTPAVYHGATEKPTEQPVEESG- 191

  Fly   197 IVTENTFPNDFYSKAPAMLIYTPNAVNSPKPVLLTHRNIEAQMRCLIGTWHLGPTDCMLPILSMN 261
                       :....||:.||......||..|.||||:.|.:..|:.:|.....|.:|.:|.::
Mouse   192 -----------WRDRGAMIFYTSGTTGRPKGALSTHRNLAAVVTGLVHSWAWTKNDVILHVLPLH 245

  Fly   262 RMHAA---LAAVLSVGGNVVLQQKFDGHNAWSALLGINSPSKQRVTLFLAMPIVYKRLIVEYEKM 323
            .:|..   |...|.||...|:..:|.....|...|...:|   ::|:|:|:|.||.:|:..|:|.
Mouse   246 HVHGVVNKLLCPLWVGATCVMLPEFSAQQVWEKFLSSEAP---QITVFMAVPTVYSKLLDYYDKH 307

  Fly   324 FAKDSRMVEYIVNHCRQKIRLMATAFALLPDSVFYRWREITGQNIYEYYGMMETGLVLGHPLNKR 388
            |.: ..:.:::...|:::||||.:..|.||..:..:||..||..:.|.|||.|.|:.|.:||.:.
Mouse   308 FTQ-PHVQDFVRAVCKERIRLMVSGSAALPVPLLEKWRSATGHTLLERYGMTEIGMALSNPLTEA 371

  Fly   389 QRDSPHNGPTAVAMANNTAPNDYRPGTLGSPLKGVTARLIS---NKGDELITCK--NELGGSVDS 448
            :                      .||::|:||.||..|:||   .||...|...  ||.|..|..
Mouse   372 R----------------------VPGSVGTPLPGVEVRIISENPQKGSPYIIHAEGNERGTKVTP 414

  Fly   449 GLIPVEDIGGDASLAGTIIGELQIAGSNLVSNTLANNNQEMEHKGTTNNEEQENNQDGFFKTGDI 513
            |....|             |||.:.|.::.          .|:.......:.....||:|:|||.
Mouse   415 GFEEKE-------------GELLVRGPSVF----------REYWDKPEETKSAFTSDGWFRTGDT 456

  Fly   514 CAYRNGNFYFLSKSS-DIFTVGGYKVYGSEIKKVLISHPNINDVAVLGIPNKMWGHRLGVICIVS 577
            ..:::..::...::| ||...|||||...||::.|::||:|.||||:|:|:..||.|:..:..:.
Mouse   457 AVFKDARYWIRGRTSVDIIKTGGYKVSALEIERHLLAHPSITDVAVIGVPDMTWGQRVTAVVALQ 521

  Fly   578 PDADIDLDAIKTYCYRHLPAHKCPT 602
            ....:....:|.:....|..:..|:
Mouse   522 EGHSLSHGDLKEWARGVLAPYAVPS 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18155	NP_996360.2	CaiC	53..604	CDD:223395	160/569 (28%)
CG18155	NP_996360.2	AFD_class_I	58..607	CDD:302604	159/564 (28%)
Acsf3	NP_659181.2	MCS	55..569	CDD:341264	159/564 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849316
Domainoid	1	1.000	166	1.000	Domainoid score	I3882
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3557
Isobase	1	0.950	-	0.946395	Normalized mean entropy	S3694
OMA	1	1.010	-	-		QHG55233
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002270
OrthoInspector	1	1.000	-	-		oto95150
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24096
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R434
SonicParanoid	1	1.000	-	-		X2297
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840