DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18155 and acs-11

DIOPT Version :9

Sequence 1:	NP_996360.2	Gene:	CG18155 / 31668	FlyBaseID:	FBgn0029945	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_494848.3	Gene:	acs-11 / 173820	WormBaseID:	WBGene00018269	Length:	505	Species:	Caenorhabditis elegans

Alignment Length:	553	Identity:	111/553 - (20%)
Similarity:	202/553 - (36%)	Gaps:	138/553 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SNVVVPTFKKAMLYPDEIAVKDINGE--YTYFQLYMAAKRLGIQISNIC-------GGAALSNVT 98
            :|:|    .:|.|..|...:..|:|:  .||.:.   .||.|...:.:.       |...::.|:
Worm    23 NNIV----SQAQLQSDPSKLLFIDGDRKTTYGEF---VKRTGQYATALTEKYNIKKGDRVMARVS 80

  Fly    99 YLCSNNALWIAIQWSCWISGQVAVPLESGQAIDQLQRQASNCKTKLLIATKEFESLAQELSQGVK 163
            ......||:||    |...|.:.:|:..|....:......:....:|::..|      ||.:..:
Worm    81 KTTDTAALYIA----CLQIGALYIPVNPGYTESEAAHYIKDATPSILVSCNE------ELDKVFR 135

  Fly   164 SATIILDHSFLPTAESVSSTSMYAKQLVAIQGVIVTENTFPNDFYSKAPAMLIYTPNAVNSPKPV 228
            ....:::...|            |.:..::....:.|:...:|     ||.:.||......||..
Worm   136 DKIRVINEDKL------------ASEAGSLNACTMIEHVEKSD-----PASVCYTSGTTGLPKGA 183

  Fly   229 LLTHRNIEAQMRCLIGTWHLGPTDC---MLPILSMNRMHAALAAVLSVGGNVVLQQKFDGHNAWS 290
            :|||.::......::..|.....|.   .||...::.::.:|...|.....::.:.||:..:...
Worm   184 ILTHGSLSNNAHDIVRDWGFTGNDYNLHALPFYHVHGLYYSLHCSLFSHSTMIWRSKFEVEDCIK 248

  Fly   291 ALLGINSPSKQRVTLFLAMPIVYKRLIVEYEKMFAKDSRMVEYIVNHCRQKIRLMATAFALLPDS 355
            .:        :..|:.:.:|..:.||:.  .|.|.|::          ...:|:..:..|.|..|
Worm   249 YM--------KNATVMMGVPTFFSRLLA--SKNFNKEA----------FGNVRVFISGSAPLSVS 293

  Fly   356 VFYRWREITGQNIYEYYGMMETGLVLGHPLNKRQRDSPHNGPTAVAMANNTAPNDYRPGTLGSPL 420
            ....:||.|||.|.|.|||.|.|::..:|||                      .:.:.||:|..:
Worm   294 TIEEFRERTGQVILERYGMTEAGVMTTNPLN----------------------GERKAGTVGPAV 336

  Fly   421 KGVTARLISNKGDELITCKNELGGSVDSGLIPVEDIGGDASLAGTIIGELQIAGSNLVSNTLANN 485
            :||..|:..|.|.|:.|                     :|..||
Worm   337 QGVGCRIAKNGGIEVKT---------------------NAIFAG--------------------- 359

  Fly   486 NQEMEHKGTTNNEEQENNQDGFFKTGDICAY-RNGNFYFLSKSSDIFTVGGYKVYGSEIKKVLIS 549
                 :........:|..:||:|||||:... .:|......:|.|:...||..||..|::..:.:
Worm   360 -----YWKNPKKTAEEFTEDGWFKTGDVGHLDEDGYLTIGGRSKDMVITGGLNVYPKELEDFIDT 419

  Fly   550 HPNINDVAVLGIPNKMWGHRLGVICIVSPDADI 582
            .|.:.:.||:..|:..:|.  .|:.||.|...:
Worm   420 LPFVKESAVIASPHPDFGE--AVVAIVVPSEKV 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18155	NP_996360.2	CaiC	53..604	CDD:223395	109/543 (20%)
CG18155	NP_996360.2	AFD_class_I	58..607	CDD:302604	107/538 (20%)
acs-11	NP_494848.3	PRK07514	34..505	CDD:181011	107/538 (20%)
acs-11	NP_494848.3	MCS	37..493	CDD:213307	106/535 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166460
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55233
OrthoDB	1	1.010	-	-		D229996at33208
OrthoFinder	1	1.000	-	-		FOG0002270
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R434
SonicParanoid	1	1.000	-	-		X2297
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.790