DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dok and DOK2

DIOPT Version :9

Sequence 1:NP_572391.1 Gene:Dok / 31667 FlyBaseID:FBgn0029944 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_003965.2 Gene:DOK2 / 9046 HGNCID:2991 Length:412 Species:Homo sapiens


Alignment Length:483 Identity:107/483 - (22%)
Similarity:165/483 - (34%) Gaps:158/483 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 VLAGYLNVPTQTGFSLNRISKKKACSRY-CLLFKASRHGIARLEMCESKE-----DRNPKIFTLE 65
            |..|:|.:..|..|.       |...|: ..|:..|...:||||:.|..|     :...|:..|.
Human     6 VKQGFLYLQQQQTFG-------KKWRRFGASLYGGSDCALARLELQEGPEKPRRCEAARKVIRLS 63

  Fly    66 NCVKITQ-----EPPPERLIHIVKRQATLTLSTSSEEELKDWITALQTVAFCD-----TSPSGGI 120
            :|:::.:     ..|.:.....::.:..|.|..:...|..||:.|:..:||..     :.|.|..
Human    64 DCLRVAEAGGEASSPRDTSAFFLETKERLYLLAAPAAERGDWVQAICLLAFPGQRKELSGPEGKQ 128

  Fly   121 G-AIEEDNDLYCSSF----DGLFIITLIPSEASIRCCIEPKTYMLQMTPTELQL-KSEDLGATIA 179
            . ...|:|:||.|:.    ...|.:|:.|:|||.||.:. .:|.|:...:.|:| ...:.|..:.
Human   129 SRPCMEENELYSSAVTVGPHKEFAVTMRPTEASERCHLR-GSYTLRAGESALELWGGPEPGTQLY 192

  Fly   180 MWPYRFIRKYGYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVFRCMSAKMKSMKKLISGDSLSTL 244
            .|||||:|::|.....|:|||||:|.:|||.|..:.....|:|..:...:.:.|           
Human   193 DWPYRFLRRFGRDKVTFSFEAGRRCVSGEGNFEFETRQGNEIFLALEEAISAQK----------- 246

  Fly   245 ECGENQFSAAAGMEPG---SRSPLPPSPSSNPHGGEFEINSTQSCISLRGFISSNDSLNNFSAGG 306
                |...|....:|.   :..|.|.||.|.||                      |||       
Human   247 ----NAAPATPQPQPATIPASLPRPDSPYSRPH----------------------DSL------- 278

  Fly   307 GGASGATATGGGVLGSTGGITLSVPANSNSNSSSSKHIPNKPPRKSPTTHCDKYRNIVKYEPVAI 371
                                                      |..||||            ||  
Human   279 ------------------------------------------PPPSPTT------------PV-- 287

  Fly   372 TTISSPSANSDVNSSVILKPLEGESISLPETAADL---PPDL---PLRNESASKAPP-PERDYEC 429
                 |:............|.:..:.||.:....:   ||.|   ||.:......|| |:..|:.
Human   288 -----PAPRPRGQEGEYAVPFDAVARSLGKNFRGILAVPPQLLADPLYDSIEETLPPRPDHIYDE 347

  Fly   430 IENIT-------------EAWRTRGVGD 444
            .|.:.             ||||.:...|
Human   348 PEGVAALSLYDSPQEPRGEAWRRQATAD 375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DokNP_572391.1 PH 6..110 CDD:214574 25/113 (22%)
PH 6..107 CDD:278594 25/110 (23%)
PH-like 138..232 CDD:302622 33/94 (35%)
DOK2NP_003965.2 PH_DOK1,2,3 7..114 CDD:270195 24/113 (21%)
PTB_DOK1_DOK2_DOK3 147..246 CDD:269914 33/99 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..296 22/154 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 359..412 5/17 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141615
Domainoid 1 1.000 64 1.000 Domainoid score I10117
eggNOG 1 0.900 - - E1_KOG4047
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004741
OrthoInspector 1 1.000 - - otm42191
orthoMCL 1 0.900 - - OOG6_110776
Panther 1 1.100 - - O PTHR21258
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5513
SonicParanoid 1 1.000 - - X1028
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.730

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