Protein Alignment Dok and Dok5

DIOPT Version :10

• Sequence 1: NP_572391.1
• Gene: Dok / 31667
• FlyBaseID: FBgn0029944
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_084037.3
• Gene: Dok5 / 76829
• MGIID: 1924079
• Length: 306
• Species: Mus musculus
• Alignment Length: 281
• Identity: 68/281 - (24%)
• Similarity: 104/281 - (37%)
• Gaps: 72/281 - (25%)

  Fly     7 VLAGYLNVPTQTGFSLNRISKKKACSRYCLLFKASRHGIARLEMCESKEDRNP------KIFTLE 65
            |..||:.:.::      |:...:.|  :.:..|||..|..|||  :..::|..      |:..|.
Mouse     9 VKQGYVRIRSR------RLGIYQRC--WLVFKKASSKGPKRLE--KFSDERAAYFRCYHKVTELN 63

  Fly    66 NCVKITQEPPPERLIHIV----KRQATLTLSTSSEEELKDWITALQTVAFCDTSPSGGIGAIEED 126
            | ||.....|.....|.:    ....:.|.:..|:.|..:|...||...         :|.  ..
Mouse    64 N-VKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMEC---------VGT--RI 116

  Fly   127 NDLYCSSFDGL-----------FIITLIPS---EASIRCCIEPKTYMLQMTPTELQL-KSEDLGA 176
            ||:.....|.|           |.:.|:||   :....|.       ||:|...:.| ..::...
Mouse   117 NDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECA-------LQITYEYICLWDVQNPRV 174

  Fly   177 TIAMWPYRFIRKYGYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVFR----------------CM 225
            .:..||...:|:||.....|||||||.|.||||:|.....:.:.:::                ..
Mouse   175 KLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQ 239

  Fly   226 SAK--MKSMKKLISGDSLSTL 244
            |.|  |..|||.....||||:
Mouse   240 SVKNSMLQMKKSERAASLSTV 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dok	NP_572391.1	PH	6..107	CDD:459697	24/109 (22%)
		IRS	138..233	CDD:460473	30/116 (26%)
Dok5	NP_084037.3	PH_DOK4_DOK5_DOK6	9..113	CDD:270197	26/123 (21%)
		PTB_DOK4_DOK5_DOK6	133..235	CDD:241318	27/108 (25%)
		DKFBH motif	263..273