Protein Alignment Dok and Dok6

DIOPT Version :10

• Sequence 1: NP_572391.1
• Gene: Dok / 31667
• FlyBaseID: FBgn0029944
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001034262.1
• Gene: Dok6 / 623279
• MGIID: 3639495
• Length: 331
• Species: Mus musculus
• Alignment Length: 330
• Identity: 79/330 - (23%)
• Similarity: 127/330 - (38%)
• Gaps: 81/330 - (24%)

  Fly     7 VLAGYLNVPTQTGFSLNRISKKKACSRYC-LLF-KASRHGIARLEMCESKED---RN----PKIF 62
            |..||:.:.          |:|....|.| |:| |||..|..|||....::.   ||    .::.
Mouse     9 VKQGYVKIR----------SRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELH 63

  Fly    63 TLENCVKITQEPPPERLIHIVKRQATLTLSTSSEEELKDWI---------TALQTVAFCDTSPSG 118
            .::|..::.:|.....:..|...:.:.|.:..||.|.::|.         |.|..::..:.....
Mouse    64 NIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLA 128

  Fly   119 GIGAIEEDNDLYCSSFDGLFIITLIPS-------EASIRCCIEPKTYMLQMTPTELQLKSEDLGA 176
            . |...|.|:        .|.:.|:|:       |.:::...| ..|:..:...:::|
Mouse   129 A-GVQREQNE--------RFNVYLMPTPNLDIYGECTMQITHE-NIYLWDIHNAKVKL------- 176

  Fly   177 TIAMWPYRFIRKYGYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVFRCMSAKMKSMKKLISGDSL 241
              .|||...:|:||.....||||:||.|.||||:||......:.:::    |:.|
Mouse   177 --VMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQ----KVHS---------- 225

  Fly   242 STLECGENQFSAAAGMEPGSR------SPLPPSPS-SNPHGGEF----EINSTQSCISLR--GFI 293
            :||...|........||..:|      .|:..|.| |.|....:    ..||.....||:  ||.
Mouse   226 ATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQNSVGEIYSLQGHGFG 290

  Fly   294 SSNDS 298
            ||..|
Mouse   291 SSKMS 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dok	NP_572391.1	PH	6..107	CDD:459697	27/117 (23%)
		IRS	138..233	CDD:460473	28/101 (28%)
Dok6	NP_001034262.1	PH_DOK4_DOK5_DOK6	9..113	CDD:270197	26/113 (23%)
		PTB_DOK4_DOK5_DOK6	133..235	CDD:241318	33/133 (25%)
		DKFBH motif	263..273		1/9 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..331		1/3 (33%)