Protein Alignment Dok and DOK5

DIOPT Version :10

• Sequence 1: NP_572391.1
• Gene: Dok / 31667
• FlyBaseID: FBgn0029944
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_060901.2
• Gene: DOK5 / 55816
• HGNCID: 16173
• Length: 306
• Species: Homo sapiens
• Alignment Length: 294
• Identity: 69/294 - (23%)
• Similarity: 114/294 - (38%)
• Gaps: 65/294 - (22%)

  Fly     7 VLAGYLNVPTQTGFSLNRISKKKACSRYCLLFKASRHGIARLEMCESKEDRNP------KIFTLE 65
            |..||:.:.::      |:...:.|  :.:..|||..|..|||  :..::|..      |:..|.
Human     9 VKQGYVRIRSR------RLGIYQRC--WLVFKKASSKGPKRLE--KFSDERAAYFRCYHKVTELN 63

  Fly    66 NCVKITQEPPPERLIHIV----KRQATLTLSTSSEEELKDWITALQTVAFCDTSPSGGIGAIEED 126
            | ||.....|.....|.:    ....:.|.:..|:.|..:|...||...         :|.  ..
Human    64 N-VKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMEC---------VGT--RI 116

  Fly   127 NDLYCSSFDGL-----------FIITLIPS---EASIRCCIEPKTYMLQMTPTELQL-KSEDLGA 176
            ||:.....|.|           |.:.|:||   :....|.       ||:|...:.| ..::...
Human   117 NDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECA-------LQITYEYICLWDVQNPRV 174

  Fly   177 TIAMWPYRFIRKYGYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVF-RCMSAKM---KSMKKLIS 237
            .:..||...:|:||.....|||||||.|.||||:|.....:.:.:: :..||.:   :..::|:.
Human   175 KLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQ 239

  Fly   238 GDSLSTLECGENQFSAAAGMEPGSRSPLPPSPSS 271
            ....|.|:...::.:|       |.|.:.|.|.|
Human   240 SVKNSMLQMKMSERAA-------SLSTMVPLPRS 266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dok	NP_572391.1	PH	6..107	CDD:459697	24/109 (22%)
		IRS	138..233	CDD:460473	29/102 (28%)
DOK5	NP_060901.2	PH_DOK4_DOK5_DOK6	9..113	CDD:270197	26/123 (21%)
		PTB_DOK4_DOK5_DOK6	133..235	CDD:241318	29/108 (27%)
		DKFBH motif	263..273		2/4 (50%)