Protein Alignment Dok and DOK4

DIOPT Version :9

• Sequence 1: NP_572391.1
• Gene: Dok / 31667
• FlyBaseID: FBgn0029944
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001317485.1
• Gene: DOK4 / 55715
• HGNCID: 19868
• Length: 365
• Species: Homo sapiens
• Alignment Length: 403
• Identity: 96/403 - (23%)
• Similarity: 139/403 - (34%)
• Gaps: 117/403 - (29%)

  Fly     7 VLAGYLNVPTQTGFSLNRISKKKACSRYC-LLF-KASRHGIARLEMCESKEDRNPKIFTLENCVK 69
            |..||:.:.          |:|....|.| |:| |:|..|..|||....:     |...|..|.|
Human     9 VKQGYVKMK----------SRKLGIYRRCWLVFRKSSSKGPQRLEKYPDE-----KSVCLRGCPK 58

  Fly    70 ITQEPPPE---RLIHIVKRQATL---------TLSTSSEEELKDWITALQTVAFCDTSPSGGIGA 122
            :|:....:   ||....||||..         |.:..||.|.::|...|...  |..|....|..
Human    59 VTEISNVKCVTRLPKETKRQAVAIIFTDDSARTFTCDSELEAEEWYKTLSVE--CLGSRLNDISL 121

  Fly   123 IEED---NDLYCSSFDGLFIITLIPSEASIRCCIEPKTY---MLQMTPTELQL-KSEDLGATIAM 180
            .|.|   ..:.|...| .|.:.|:|       |.....|   .||:|...:.| ...:....:..
Human   122 GEPDLLAPGVQCEQTD-RFNVFLLP-------CPNLDVYGECKLQITHENIYLWDIHNPRVKLVS 178

  Fly   181 WPYRFIRKYGYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVF-RCMSAKM--------------K 230
            ||...:|:||....:|||||||.|..|||::|......:::: |..||.:              |
Human   179 WPLCSLRRYGRDATRFTFEAGRMCDAGEGLYTFQTQEGEQIYQRVHSATLAIAEQHKRVLLEMEK 243

  Fly   231 SMKKLISGDSLSTLECGE---------------NQFSAAAGMEPGSRSPLPPSPS-------SNP 273
            :::.|..|....:..|..               :|..|.|....|...|. |:|:       ..|
Human   244 NVRLLNKGTEHYSYPCTPTTMLPRSAYWHHITGSQNIAEASSYAGESLPC-PTPTCQEALWRMRP 307

  Fly   274 HG-GEFEINSTQSCISL---RGF-----ISSNDSLNNFSAGGGGASGATATGGGVLGSTGGITLS 329
            .| |.|::..:....|:   .|:     .|..|.||.|                        .|.
Human   308 IGQGSFDLALSSEPASVPTGEGYGAAQASSETDLLNRF------------------------ILL 348

  Fly   330 VPANSNSNSSSSK 342
            .|..|..:||.:|
Human   349 KPKPSQGDSSEAK 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dok	NP_572391.1	PH	6..110	CDD:214574	32/116 (28%)
		PH	6..107	CDD:278594	31/113 (27%)
		PH-like	138..232	CDD:302622	30/112 (27%)
DOK4	NP_001317485.1	PH_DOK4_DOK5_DOK6	9..113	CDD:270197	33/120 (28%)
		PTB_DOK4_DOK5_DOK6	133..235	CDD:241318	31/109 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141613
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4047
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21258
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840