Protein Alignment Dok and Frs2

DIOPT Version :10

• Sequence 1: NP_572391.1
• Gene: Dok / 31667
• FlyBaseID: FBgn0029944
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001101567.2
• Gene: Frs2 / 314850
• RGDID: 1308201
• Length: 508
• Species: Rattus norvegicus
• Alignment Length: 520
• Identity: 104/520 - (20%)
• Similarity: 182/520 - (35%)
• Gaps: 155/520 - (29%)

  Fly   159 MLQMTPTELQLKSEDLGATIAMWPYRFIRKYGYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVFR 223
            ::::|.|||.|.:....:  ..|.|..:|:|||....|:||:||:|.||:|:|.......:|:|
  Rat    37 VMELTDTELILYTRKRDS--VKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELF- 98

  Fly   224 CMSAKMKSMKKLISGDSLSTLE---CGENQFSAAAGMEPGSRSPLPPS------PSSNPHGGEFE 279
                  ..:::::..:|::.:|   ...|.......:....|:|..|.      |:..|....|
  Rat    99 ------NMLQEIMQNNSINVVEEPVVERNSHQTELEVPRTPRTPTTPGLGAQSLPNGYPRYPSF- 156

  Fly   280 INSTQSCISLRGFISSNDSLNNFSAGGG--GASGATATGGGVLG--------STGGITLSVPANS 334
                       |..||:.|..:.|.|..  .:.|..:|...::.        :|.|:      ..
  Rat   157 -----------GDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGV------QE 204

  Fly   335 NSNSSSSKHIP---------NKPPRKSPTTHCDKYRNIV-----------------------KYE 367
            ...:.:|.|||         :..|::.|:...|:..:::                       |.|
  Rat   205 ERKNRASVHIPPEARVSNAESNTPKEEPSNTEDRDPHVLLKPEGVKFVLGPTPVQKQLMEKEKLE 269

  Fly   368 PVAITTISSPSANS-------------DVN--SSVILKPLEGESISLPETA--------ADLPPD 409
            .:....:|...|:|             ||.  :.::.:.:.|  :|:|..:        :....|
  Rat   270 QLGKDQVSGSGASSTEWDTGYDSDERRDVPPVNKLVYENING--LSIPSASGVRRGRLTSTSTSD 332

  Fly   410 LPLRNESASKAPPPERDYECIENITEAWRTRGVG---DVRHSERMPIL-------------CDTS 458
            ....|.||.:. |...:||.:.::...|..|.:.   |.....:.|.|             .:|.
  Rat   333 TQNINNSAQRR-PALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTE 396

  Fly   459 EFVRQRSVSKSTCGSQN--TPKIIDIDIGEGCTSATSISESNYDRLDFL----SPNNKTSSGYKT 517
            ......|..|..|..:.  ||.:.:.||..   .:....:.||.::|..    |.|.:|.....|
  Rat   397 NVTVPASAHKIDCSRRRDCTPTVFNFDIRR---PSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTT 458

  Fly   518 IVNVTPGNRIRCSPPPPNEYELIASPDTE------SFRKA---DDSHRGYGVLRKASTTTNNNNL 573
            .:..||..|.          ||.|..|.|      :.:||   ||     |..||  |..|:.:|
  Rat   459 PLPQTPTRRT----------ELYAVIDIERTAAMSNLQKALPRDD-----GTSRK--TRHNSTDL 506

  Fly   574  573
              Rat   507  506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dok	NP_572391.1	PH	6..107	CDD:459697
		IRS	138..233	CDD:460473	23/73 (32%)
Frs2	NP_001101567.2	PTB_FRS2	15..106	CDD:269913	23/77 (30%)